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Efficacy of a Multiplex Paclitaxel Emission Stent Using a Pluronic® Mixture Membrane versus a Covered Metal Stent in Malignant Biliary Obstruction: A Prospective Randomized Comparative Study
Gut and Liver ; : 567-573, 2017.
Article 在 En | WPRIM | ID: wpr-88938
Responsible library: WPRO
ABSTRACT
BACKGROUND/AIMS: A drug-eluting stent for unresectable malignant biliary obstruction was developed to increase stent patency by preventing tumor ingrowth. The safety and efficacy of a new generation of metallic stents covered with a paclitaxel-incorporated membrane using a Pluronic® mixture (MSCPM-II) were compared prospectively with those of covered metal stents (CMSs) in patients with malignant biliary obstructions. METHODS: This study was initially designed as a prospective randomized trial but was closed early because of a high incidence of early occlusion. Therefore, the data were analyzed using the intent-to-treat method. A total of 72 patients with unresectable distal malignant biliary obstructions were prospectively enrolled. RESULTS: The two groups did not differ significantly in basic characteristics and mean follow-up period (MSCPM-II 194 days vs CMS 277 days, p=0.063). Stent occlusion occurred in 14 patients (35%) who received MSCPM-II and in seven patients (21.9%) who received CMSs. Stent patency and survival time did not significantly differ between the two groups (p=0.355 and p=0.570). The complications were mild and resolved by conservative management in both groups. CONCLUSIONS: There were no significant differences in stent patency or patient survival in MSCPM-II and CMS patients with malignant biliary obstructions.
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全文: 1 索引: WPRIM 主要主题: Pancreatic Neoplasms / Biliary Tract Neoplasms / Stents / Incidence / Prospective Studies / Follow-Up Studies / Paclitaxel / Drug-Eluting Stents / Self Expandable Metallic Stents / Membranes 研究类型: Clinical_trials / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies 限制: Humans 语言: En 期刊: Gut and Liver 年: 2017 类型: Article
全文: 1 索引: WPRIM 主要主题: Pancreatic Neoplasms / Biliary Tract Neoplasms / Stents / Incidence / Prospective Studies / Follow-Up Studies / Paclitaxel / Drug-Eluting Stents / Self Expandable Metallic Stents / Membranes 研究类型: Clinical_trials / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies 限制: Humans 语言: En 期刊: Gut and Liver 年: 2017 类型: Article