Association between Ser9Gly Polymorphism of DRD3 Gene and Depression in Parkinson's Disease / 中国康复理论与实践

ABSTRACT

Objectives:To explore the relationship between the dopamine D3 receptor (DRD3) polymorphism on Ser9Gly and depression in Parkinson's disease (PD). Methods:From June, 2016 to June, 2018, 312 Chinese patients with PD were divided into depression group (n = 132) and non-depression group (n = 180) according to scores of Hamilton Depression Scale. A total of 252 age- and gender-matched healthy subjects were recruited as control group. Their blood samples were collected. Genotyping of Ser9Gly polymorphism was carried out using polymerase chain reaction-restriction fragment length polymorphism. Results:No statistical difference was identified in Ser9Gly polymorphism among three groups in both gene types and allel (χ2 = 3.095, χ2 = 2.627, P > 0.05). Conclusion:Ser9Gly polymorphism in DRD3 gene may not be a susceptible factor for depression in PD in China.