ABSTRACT
Objective:
To explore the characteristics of
cerebral blood flow changes in MRI
perfusion imaging in
patients with
Parkinson disease (PD)
cognition disorders and its correlation with
serum epidermal growth factor (
EGF) level.
Methods:
One hundred and twenty PD
patients diagnosed and treated from September 2017 to September 2020 in Hangzhou Third People′s
Hospital were selected. According to the presence of
mild cognitive impairment (MCI), they were divided into PD-MCI group (60 cases) and PD without
cognition impairment (PD-NCI) group (60 cases). Another 60 cases of healthy
physical examination during the same period were selected as the normal
control group. MRI
perfusion imaging was used to evaluate the cerebral vascular
perfusion in each group, and the
EGF level of each group was determined by
enzyme-linked immunosorbent assay and compared.
Results:
The CBF and CBV in the PD-MCI group and PD-NCI group were lower than those in the normal
control group, while the MTT was longer than that in the normal
control group(14.78 ± 2.49), (18.21 ± 2.84) ml/(100 g·min) vs. (18.21 ± 2.84) ml/(100g·min); (1.42 ± 0.29), (1.83 ± 0.31) ml/100 g vs. (2.87 ± 0.54) ml/100 g; (10.53 ± 2.18), (7.85 ± 1.39) s vs. (4.29 ± 1.05) s, and the differences were statistically significant ( P<0.05). The CBF and CBV in the PD-MCI group were lower than those in the PD-NCI group, while MTT was longer than that in the PD-NCI group, and the differences were statistically significant ( P<0.05). The level of
serum EGF in the PD-MCI group and PD-NCI group were lower than those in the normal
control group (146.25 ± 30.12), (208.17 ± 21.25) ng/L vs. (242.38 ± 25.46) ng/L; the level of
serum EGF in the PD-MCI group was lower than that in the PD-NCI group, and the differences were statistically significant ( P<0.05). CBF, CBV and
EGF were linearly positively correlated with Montreal Cognitive Assessment Scale (MoCA) scores ( r1 = 0.810, r2 = 0.732, r3 = 0.825, P<0.05), while MTT was linearly negatively correlated with MoCA scores ( r4 = -0.756, P<0.05).
Conclusions:
PD-MCI
patients have abnormal
cerebral blood flow, and
serum EGF level decrease. In PD-MCI
patients, CBF, CBV and
EGF are linearly positively correlated with MoCA scores, while MTT is linearly negatively correlated with MoCA scores.