ABSTRACT
Objective:
To investigate the
therapeutic effect of Yanghe decoction combined with Tounongpowder on
patients with acute
plasma cell mastitis and its influence on inflammatory factors.
Methods:
A total of 120
patients with acute
plasma cell mastitis admitted to Yantai Affiliated
Hospital of Binzhou Medical College from May 2019 to May 2020 were selected, and divided into
control group (60 cases) and combination group (60 cases). The
control group was treated with western
medicine, and the combination group was treated with Yanghe decoction and Tounongpowder on the basis of the
control group. Seven days was 1
course and a total of 4
courses were continued. The scores of
symptoms and signs and clinical effects of the two groups before
treatment and 1 month
after treatment were compared. The
serum interleukin(IL)-1β and
IL-6 were measured by
radioimmunoassay, and
tumor necrosis factor-α(TNF-α) was measured by
enzyme-linked immunosorbent assay.
Results:
After 1 month of
treatment, the scores of
breast swelling,
breast lumps,
breast pain,
breast fistula symptoms and signs in the two groups were significantly decreased, the scores of above index in the combination group were significantly lower than those in the
control group, and the differences were statistically significant ( P<0.05). The total effective rate in the combined group was higher than that in
control group 91.7%(55/60) vs. 76.7% (46/60), and the difference was statistically significant ( χ2 = 8.456, P<0.05). After 1 month of
treatment, the
serum levels of
IL-1β,
IL-6 and TNF-α in the two groups were significantly reduced, and the
serum levels of above 3 index in the combination group were significantly lower than those in the
control group (3.24 ± 0.92) ng/L vs. (3.81 ± 1.02) ng/L, (1.12 ± 0.42) ng/L vs. (1.41 ± 0.35) ng/L, (32.27 ± 19.03) ng/L vs. (43.04 ± 21.58) ng/L, and the differences were statistically significant ( P<0.05).
After treatment, the
liver and
kidney functions of the two groups were not abnormal, and the differences in adverse reactions such as
headache,
dizziness,
nausea and
vomiting were not statistically significant ( P>0.05).
Conclusions:
Yanghe decoction combined with Tounongpowder can significantly improve the clinical symptoms of
patients with acute
plasma cell mastitis, with a definite clinical effect. Its mechanism of action may be related to reducing the levels of
IL-1β,
IL-6, and TNF-α and reducing the inflammatory response.