ABSTRACT
Objective:
This study examined the
associations between the levels of
bile acids in early
pregnancy and the occurrence of
overweight.
Methods:
From 2010 to 2012, 22 302
pregnant women were recruited by Tianjin
Women and
Children′s
Health Center to investigate
gestational diabetes. Two hundred and forty-three
women with
gestational diabetes mellitus provided overnight
fasting blood samples in the
first trimester, and 243 counterparts without
gestational diabetes mellitus matched on age were selected randomly to establish a
nested case-control study. The
association between
bile acids and
overweight were evaluated by binary
logistic regression with data from 166
overweight pregnant women (
body mass index≥24.0 kg/m 2) and 320 normal weight subjects (
body mass index <24.0 kg/m 2).
Results:
Compared to non-
overweight group, the level of primary unconjugated
bile acids in
overweight group was significantly higher. After
adjustment of confounding factors, the OR of
cholic acid (CA)>0.086 nmol/mL for
overweight was 2.09 (95% CI 1.14-3.80, adjusted P=0.040), and OR of
chenodeoxycholic acid (CDCA)>0.043 nmol/mL was 2.15 (95% CI 1.22-3.78, adjusted P=0.040) compared with the lower groups. However, the significant
associations between the other
bile acids and
overweight were not detected. Stepwise selection was used to identify significant
bile acid species in
logistic regression. We found that only CA was independently associated with
overweight, and the OR of CA>0.086 nmol/mL vs≤0.086 nmol/mL was 2.03 (95% CI 1.11-3.74, P=0.022).
Conclusion:
CA and CDCA in early
pregnancy maybe associated with
overweight, and CA might be independently associated with
overweight.