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Role of Radiofrequency Ablation in Patients with Hepatocellular Carcinoma Who Undergo Prior Transarterial Chemoembolization: Long-Term Outcomes and Predictive Factors
Gut and Liver ; : 543-551, 2014.
Article 在 En | WPRIM | ID: wpr-91772
Responsible library: WPRO
ABSTRACT
BACKGROUND/AIMS: The role of radiofrequency ablation (RFA) remains uncertain in patients with viable hepatocellular carcinoma (HCC) after transarterial chemoembolization (TACE). METHODS: A total of 101 patients (April 2007 to August 2010) underwent RFA for residual or recurrent HCC after TACE. We analyzed their long-term outcomes and predictive factors. RESULTS: The overall survival rates after RFA were 93.1%, 65.4%, and 61.0% at 1, 3, and 5 years, respectively. Predictive factors for favorable overall survival were Child-Pugh class A (hazard ratio [HR], 3.45; p=0.001), serum alpha-fetoprotein (AFP) level or =20 ng/mL (HR, 3.02; p or =30 mm at RFA (HR, 2.90; p=0.005), and nonresponse to the last TACE (HR, 2.13; p=0.013). CONCLUSIONS: Patients with recurrent or residual HCC who undergo prior TACE show a favorable overall survival, although their tumors seem to recur early and frequently. While good liver function, a low serum AFP level, and recurrent tumors were independent predictive factors for a favorable overall survival, poor response to TACE, a high serum AFP level, and large tumors are associated with early recurrence.
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全文: 1 索引: WPRIM 主要主题: Alpha-Fetoproteins / Survival Rate / Treatment Outcome / Chemoembolization, Therapeutic / Catheter Ablation / Combined Modality Therapy / Carcinoma, Hepatocellular / Liver Neoplasms / Neoplasm Recurrence, Local 研究类型: Prognostic_studies 限制: Aged / Female / Humans / Male 语言: En 期刊: Gut and Liver 年: 2014 类型: Article
全文: 1 索引: WPRIM 主要主题: Alpha-Fetoproteins / Survival Rate / Treatment Outcome / Chemoembolization, Therapeutic / Catheter Ablation / Combined Modality Therapy / Carcinoma, Hepatocellular / Liver Neoplasms / Neoplasm Recurrence, Local 研究类型: Prognostic_studies 限制: Aged / Female / Humans / Male 语言: En 期刊: Gut and Liver 年: 2014 类型: Article