ABSTRACT
Objective:
To investigate clinicopathological features of 4 cases of intravascular large
B-cell lymphoma (IVLBCL) .
Methods:
Clinical and pathological data were collected from 4
patients with histopathologically confirmed IVLBCL in Department of
Dermatology,
Peking Union Medical College
Hospital from January 2020 to November 2020, and retrospectively analyzed.
Results:
The 4
patients were
aged 57 - 76 years, including 2
males and 2
females. Of the 4
patients, all had neurological symptoms, 3 had
fever, 3 exhibited impaired
exercise tolerance and
suffocation, and 3 exhibited pitting
edema of the body. Case 1 presented with a cherry
hemangioma-like papule measuring 0.2 cm in diameter on the
back, and case 2 with
telangiectasia on the left
breast and upper
abdomen. Six
skin samples were taken from the 4
patients for histopathological and immunohistochemical studies, and
tumor cells were found in 1 cherry
hemangioma-like lesion and 1 lesion of
telangiectasia, as well as in 2 of 4 normal
skin samples. Histopathological findings mainly were dilated dermal
blood vessels filled with large atypical mononuclear
cells, and the atypical mononuclear
cells were positive for CD20 immunohistochemically.
Conclusion:
For those
patients with suspected IVLBCL,
hemangioma-like and
telangiectasia lesions tend to show characteristic histopathological and immunohistochemical findings, and a
biopsy of normal
skin can facilitate
early diagnosis of IVLBCL.
