The role of Notch signaling pathway in immune regulation of sepsis / 国际儿科学杂志

ABSTRACT

Sepsis is a clinical syndrome manifested by organ dysfunction due to disordered inflammatory response after severe infection.The occurrence, development and prognosis of sepsis are closely related to the immune regulation of the body.The essence of sepsis is that the state of excessive proinflammatory response in the early stage gradually progresses to the state of immunosuppression in the late stage, which leads to the body′s inability to resist inflammation and endangers life.As a highly conserved signaling pathway, Notch pathway has the ability to regulate cell growth and differentiation, and participates in the occurrence and development of various inflammatory diseases.In recent years, the important role of Notch signaling pathway in the occurrence and development of sepsis has attracted extensive attention.This article mainly reviews the role of Notch signaling pathway in immune regulation of sepsis.