ABSTRACT
Objective:
To investigate the correlation among
serum inflammatory
factors, coagulation function and immune function and the condition of
elderly patients with
chronic obstructive pulmonary disease (
COPD).
Methods:
One hundred and twenty-eight
elderly patients with
COPD treated in Zhuji Central
Hospital from January 2018 to December 2019 were selected and divided into acute attack group (72 cases) and stable group (56 cases) according to the
patient′s condition; another 60
elderly healthy people from January 2018 to January 2019 were selected as the
control group. The levels of
amyloid A (SAA), C-reaction
protein (CRP) and
procalcitonin (PCT), D-Dimer (D-D),
fibrinogen (FIB) and
T lymphocyte subsets were compared among the three groups. The percentage of the first second expiratory volume to predicted value (FEV 1%) and the ratio of the first second expiratory volume (FEV 1) and
forced vital capacity (FVC) were compared among the three groups. The arterial
partial pressure of
oxygen (PaO 2) and arterial
partial pressure of
carbon dioxide (PaCO 2) were compared among the three groups.
Results:
The levels of
serum CRP, SAA and PCT in the acute attack group and stable group were higher than those in the
control group and the levels of
serum CRP, SAA and PCT in the acute attack group were higher than those in the stable group (37.29 ± 7.67) mg/L vs. (18.29 ± 3.54) mg/L, (41.32 ± 5.45) mg/L vs. (14.35 ± 3.19) mg/L, (3.87 ± 0.65) ng/L vs. (1.02 ± 0.15) ng/L, the differences were statistically significant ( P<0.05). The
serum D-D and FIB levels in the acute attack group and stable group were higher than those in the
control group and the
serum D-D and FIB levels in the acute attack group were higher than those in the stable group (3.27 ± 0.36) mg/L vs. (1.08 ± 0.27) mg/L, (3.98 ± 0.56) mg/L vs. (3.07 ± 0.45) mg/L, the differences were statistically significant ( P<0.05). The CD 3+, CD 4+ and CD 4+/CD 8+ levels in the acute attack group and stable group were lower than those in the
control group and the CD 3+, CD 4+ and CD 4+/CD 8+ levels in the acute attack group were lower than those in the stable group0.598 ± 0.062 vs. 0.678 ± 0.046, 0.345 ± 0.032 vs.0.383 ± 0.034, 1.25 ± 0.21 vs. 1.48 ± 0.19, the differences were statistically significant ( P<0.05). The FEV 1% and FEV 1/FVC levels in the acute attack group and stable group were lower than those in the
control group and the FEV 1% and FEV 1/FVC levels in the acute attack group were lower than those in the stable group (43.21 ± 3.65)% vs. (58.98 ± 4.52)%, (42.19 ± 3.25)% vs. (54.38 ± 4.87)%, the differences were statistically significant ( P<0.05). The PaO 2 in the acute attack group and stable group was lower than that in the
control group, while PaCO 2 in the acute attack group and stable group was higher than that in the
control group, the PaO 2 in the acute attack group was lower than that in the stable group and PaCO 2 in the acute attack group was higher than that in the stable group (54.53 ± 5.45) mmHg(1 mmHg = 0.133 kPa) vs. (78.71 ± 7.40) mmHg, (68.68 ± 6.54) mmHg vs. (45.23 ± 4.25) mmHg, the differences were statistically significant ( P<0.05).
Conclusions:
The
elderly patients with
COPD have obvious inflammatory reaction, abnormal coagulation function and decreased immune function. With the progress of the
disease, the inflammatory reaction, abnormal coagulation function and decreased immune function are more obvious.