ABSTRACT
Objective:
The aims of the study were to investigate the relationship among atherogenic index of
plasma (AIP) and inflammatory
adipocytokines with the severity of
coronary artery calcification (CAC) score in
coronary artery disease (CAD). And then we analyzed the diagnostic value of the new markers on CAC.
Methods:
A total of 241
patients with CAD diagnosed by coronary
CT angiography (
CTA) and
coronary angiography in Baoding First Central
Hospital from June 2019 to June 2020 were retrospectively enrolled. According to the presence of calcification in coronary
CTA, they were divided into CAC group ( n=63) and non-CAC group ( n=178). The clinical data of the
patients were collected, and the levels of
serum inflammatory factors were measured by
enzyme-linked immunosorbent assay (
ELISA). The correlation between CAC score and AIP and inflammatory
cytokines was analyzed. The diagnostic value of AIP and inflammatory factors in the formation of CAC in
patients with CAD.
Results:
The levels of AIP,
serum osteoprotegerin (OPG) and oligomeric matrix
protein (COMP) in CAC group were higher than those in non-CAC group, while the levels of
serum fibroblast growth factor 21 (FGF21) were lower than those in non-CAC group, with statistically significant difference (all P<0.01). Correlation
analysis showed that CAC score of CAD
patients was positively correlated with AIP, OPG and COMP ( r=0.581, 0.451, 0.326, P<0.05), and negatively correlated with FGF21 ( r=-0.294, P<0.05).
Receiver operating characteristic (ROC) curve
analysis showed that AIP, OPG, COMP and FGF21 had diagnostic value for CAC in CAD
patients (all P<0.05). AIP>0.387, OPG>5.150 ng/ml, FGF21>136.35 pg/ml, COMP>733.16 ng/ml were independent factors affecting the formation of CAC (all P<0.05).
Conclusions:
The increase of AIP and the change of inflammatory factors can be used as markers for the
diagnosis of CAC formation in CAD
patients.