ABSTRACT
AIM:
To systematically evaluate the effects of low-energy
red light on choroidal thickness(ChT), spherical equivalent(SE), and axial length(AL)in myopic
children.
METHODS:
A total of 8 databases, including
Pubmed, Embase, Cochrane
Library, Web of
Science, CNKI, WanFang Database, VIP Database and
China Biomedical
Literature Database, were electronically retrieved to collect the clinical
randomized controlled trial(RCT)of low-energy
red light in
myopia, with
red light intervention as an experimental group and
glasses as a
control group. The retrieval
time limit is from the establishment of the database to January 2023. According to the recommendation of the Cochrane
Handbook,
literature quality and
risk of
bias were evaluated. Revman5.4
software was used for
Meta-analysis.
RESULTS:
Totally 8 RCT about red-
light treatment with
myopia were included. The
sample size for ChT
analysis contained 407
eyes in the red-
light group and 425
eyes in the
control group; SE
analysis included 490
eyes in the red-
light group and 518
eyes in the
control group;
sample size for AL
analysis were 518
eyes in the red-
light group and 539
eyes in the
control group. The differences in ChT, SE and AL between the groups were statistically significant(ChT WMD=37.81, 95%CI 21.55~54.07, P<0.001; SE WMD=0.58, 95%CI 0.46~0.71, P<0.001; AL WMD=-0.31, 95%CI -0.39~-0.24, P<0.001).
CONCLUSION:
Specific
red light can promote the increase of ChT while inhibit SE and AL. However, its long-term
efficacy and side effects remain unclear. The above conclusions need to be further clarified by more RCT with large samples.