Mitochondrial apoptotic signaling pathway in neurons following brain injury induced by hypoxia / 法医学杂志
Journal of Forensic Medicine
; (6): 178-182, 2004.
Article
在 Zh
| WPRIM
| ID: wpr-983042
Responsible library:
WPRO
ABSTRACT
Impairment of neuronal mitochondria following hypoxia of brain not only result in nerve cell's energy-deprivation and dysfunction, mitochondria also play key roles in apoptosis of neurons. A central step being the release of cytochrome c (cyt c) across the outer mitochondrial membrane into the cytoplasm through opening of the mitochondrial permeability transition pore. Releasing of cytochrome c induce to downstream consequences of specific caspase activation. The antiapoptotic and proapoptotic members of the Bcl-2 family regulate mitochondrial activities relevant to apoptotic signaling by influencing the realaseing of cyt c.