Gene detection of GPD1-L and the association with sudden unexplained death syndrome in young adults / 法医学杂志
Journal of Forensic Medicine
; (6): 348-352, 2013.
Article
在 Zh
| WPRIM
| ID: wpr-983849
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To analyze the variations of glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L) and address the association with sudden manhood death syndrome (SMDS).@*METHODS@#The genomic DNA was extracted from blood samples of the SMDS group and the normal control group. The exons, exon-intron boundaries and 3'-UTRs of coding region of GPD1-L were PCR amplified and DNA sequenced directly to confirm the types of variations. The genotype frequency and allele frequency were analyzed statistically.@*RESULTS@#There were two variants in the SMDS group, c.465C>T and c.*18G>T, the latter existed certain degree difference of genotype distribution and allele frequency between the SMDS group and the control group, but there was no statistically significant (P > 0.05).@*CONCLUSION@#The relation between gene mutation of GPD1-L and the occurrence of Chinese SMDS deserves a further research.
全文:
1
索引:
WPRIM
主要主题:
DNA Mutational Analysis
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Base Sequence
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Case-Control Studies
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Polymerase Chain Reaction
/
Exons
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DNA Primers
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Polymorphism, Single Nucleotide
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Death, Sudden
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Asian People
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Gene Frequency
限制:
Adolescent
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Adult
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Humans
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Male
语言:
Zh
期刊:
Journal of Forensic Medicine
年:
2013
类型:
Article