ABSTRACT
Objective:
To study the effect of
iodine excess on
antioxidant capacity and
blood lipid in
adult.
Methods:
A
survey was conducted in areas with different
iodine nutrition levels in Shandong and Shanxi provinces to collect
fasting morning
urine and venous
blood samples of
adults. Urinary
iodine,
serum levels of
superoxide dismutase(SOD),
malondialdehyde (MDA), total
cholesterol (TCHO),
triglyceride (TG),
apolipoprotein A1 (apoA1) and
apolipoprotein B (
apoB),
high density lipoprotein cholesterol (HDL-C) and
low density lipoprotein cholesterol (LDL-C) were determined. According to the median urinary
iodine of the
population in the investigated village, they were divided into appropriate
iodine group (100-299 μg/L) and
iodine excess group (≥300 μg/L) . Multiple
linear regression was used to analyze the effects of
iodine nutrition and other factors on
oxidative stress indexes and
blood lipids. Partial correlation
analysis was used to analyze the relationship between
iodine nutrition and
oxidative stress indexes and
blood lipids.
Results:
A total of 1 049 subjects were included, including 471 in the appropriate
iodine group and 578 in the
iodine excess group. The median (quartile) urinary
iodine of the appropriate
iodine group and the
iodine excess group was 228.70 (157.02, 341.49) and 558.73 (298.06, 985.06) μg/L, respectively. The
serum SOD level of the appropriate
iodine group and the
iodine excess group was 12.60 (10.83, 14.10) and 11.29 (9.18, 13.10) U/ml, respectively, and the difference between the groups was statistically significant ( U = 92 697.50, P < 0.001). There were statistically significant differences in
serum TG, HDL-C and
apoB levels between the appropriate
iodine group and the
iodine excess group ( U = 108 879.50, 96 613.50, 99 050.50, P < 0.05). The results of multiple
linear regression showed that after excluding age,
gender and
body mass index (BMI), there was a negative correlation between
iodine nutrition and
serum SOD and HDL-C levels [standard regression coefficient ( β) = - 0.196, - 0.294, P < 0.001]. Partial correlation
analysis showed that there was a negative correlation between
iodine nutrition and
serum SOD and HDL-C levels [correlation coefficient ( r) = - 0.16, - 0.09, P < 0.05].
Conclusion:
Excessive
iodine intake
affects oxidative stress and
lipid metabolism in
human body.