ABSTRACT
Objective:
To investigate the
efficacy of phenolamine in the
treatment of
sepsis-induced myocardial dysfunction and its effect on cardiac function, myocardial
injury index, and
hemodynamics in
patients.
Methods:
The clinical data of 79
patients with
sepsis-induced myocardial dysfunction
who received
treatment in Huangshi Central
Hospital, Edong
Healthcare Group from February 2017 to February 2020 were retrospectively analyzed. These
patients were divided into a
control group (without phenolamine
treatment, n = 41) and an
observation group (with phenolamine
treatment, n = 38) according to whether they received phenolamine
treatment or not.
Clinical efficacy, cardiac function, myocardial
injury index, and
hemodynamic index pre- and post-
treatment were compared between the two groups.
Results:
There was no significant difference in 28-day mortality rate between the two groups ( P > 0.05).
Intensive care unit length of stay and
mechanical ventilation duration in the
observation group were (9.33 ± 3.52) days and 83.00 (28.50, 138.00) hours, which were significantly shorter than (12.17 ± 4.15) days and 111.00 (47.50, 169.00) hours in the
control group ( t = 3.26, Z = -2.27, both P < 0.05). The response rate in the
observation group was significantly higher than that in the
control group [81.58% (31/38) vs. 60.98% (25/41), χ2 = 4.05, P < 0.05]. After 7 days of
treatment, the left
ventricular ejection fraction in each group was significantly increased, and the left ventricular end-diastolic diameter and left ventricular end-systolic diameter in each group were significantly decreased compared with before
treatment (all P < 0.05). After 7 days of
treatment, the left
ventricular ejection fraction in the
observation group was significantly higher than that in the
control group ( t = 3.29, P < 0.05), and left ventricular end-diastolic diameter and left ventricular end-systolic diameter were significantly lower than those in the
control group ( t = 5.94, 11.21, both P < 0.05). N-terminal pro-
brain natriuretic peptide and cardiac
troponin I levels in each group were significantly decreased with
time (both P < 0.05). At 24 and 72 hours and 7 days
after treatment, N-terminal pro-
brain natriuretic peptide and cardiac
troponin I levels in the
observation group were significantly lower than those in the
control group (both P < 0.05). After 7 days of
treatment,
heart rate in each group decreased significantly compared with that before
treatment (both P < 0.05),
mean arterial pressure, cardiac index, and
stroke output index in each group increased significantly compared with those before
treatment (all P < 0.05). After 7 days of
treatment,
heart rate in the
observation group was significantly lower than that in the
control group ( t = 4.90, P < 0.05), and
mean arterial pressure, cardiac index, and
stroke output index in the
observation group were significantly higher than those in the
control group ( t = 4.37, 3.23, 6.01, all P < 0.05).
Conclusion:
Phentolamine can improve
hemodynamics, reduce myocardial
injury and improve cardiac function in
patients with
sepsis-induced myocardial dysfunction.