ABSTRACT
Objective:
To explore the prognostic value of
tumor deposits (TD) by number and anatomical distribution in
gastric cancer (GC)
patients without
lymph node metastasis.
Methods:
From Aug 2012 to Aug 2018 all 91 GC
patients undergoing radical
gastrectomy and without nodal
metastasis at Yijishan
Hospital of Wannan Medical College were enrolled in this study.
Patients were divided into L1, L2, and L3 groups according to the number of TD and into Q1 and Q2 groups according to the anatomical regions of the TD.
Results:
The 3-year overall
survival (OS) rates of groups L1, L2, and L3 were 58.9%, 52.1%, and 31.5%, respectively ( χ2=9.769, P=0.008). The 3-year OS rates of groups Q1 and Q2 were 58.9% and 7.1% ( χ2=46.310, P<0.001). The number of TD, their distribution, neural invasion, vascular invasion,
tumor size, and pT stage were all related to
prognosis by univariate
analysis (all P<0.05).
Tumor size>4 cm ( HR=2.460, 95% CI1.307-4.629, P=0.005), distribution of TD (non-perigastric)( HR=3.959, 95% CI2.077-7.545, P<0.001), neural invasion ( HR=4.299,95% CI1.953-9.461, P<0.001), and pT 4 stage ( HR=2.283, 95% CI1.250-4.171, P=0.007) were independent
risk factors for
prognosis by
multivariate analysis.
Conclusion:
The distribution of TD (non-perigastric) is an independent
risk factor for poor
prognosis in
gastric cancer patients after radical
gastrectomy and with negative
lymph node metastasis.