ABSTRACT
AIM:
To investigate the effect of modified Chufeng Yisun Decoction on ocular surface
inflammation after
pterygium surgery.
METHODS:
A total of 60
patients(60
eyes)with primary
pterygium who underwent
pterygium surgery were randomly divided into
control group and study group, with 30 cases(30
eyes)in each group. In the
control group,
patients were treated with pranoprofen
eye drops,
tobramycin dexamethasone eye drops, and deproteinized calf
blood extract
eye gel after the
surgery. In the study group,
patients were treated by oral modified Chufeng Yisun Decoction in addition to the
treatments in the
control group. The changes of ocular irritation symptoms, ocular inflammatory signs,
tear interleukin 6(
IL-6)levels, and
tear ferning test(TFT)of
patients in the two groups were assessed.
RESULTS:
The visual analogue scale(VAS)in
patients of both groups was significantly lower at 2d and 1wk after the
surgery than that at 1d after the
surgery(all P<0.01), and the VAS of the study group was significantly better than that of the
control group at 2d and 1wk after
surgery(P<0.01). The ocular signs integrals(OSI)and TFT results of both groups at 1wk were significantly lower than those at 1d after the
surgery(all P<0.01), and the OSI and TFT were also lower in the study group than in the
control group at 1wk after the
surgery(all P<0.01). In addition, the concentration of
tear IL-6 in both groups was significantly lower at 1wk after the
surgery than 1d after the
surgery(all P<0.01), and it was also significantly lower in the study group than in the
control group at 1wk after the
surgery(P<0.05).
CONCLUSION:
The combination of Chufeng Yisun Decoction and conventional
treatment of western has a better effect on controlling ocular surface
inflammation after
pterygium surgery.