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1.
Asian J Androl ; 2022.
Article in English | PubMed | ID: covidwho-1975058

ABSTRACT

Studies have investigated the effects of androgen deprivation therapy (ADT) use on the incidence and clinical outcomes of coronavirus disease 2019 (COVID-19);however, the results have been inconsistent. We searched the PubMed, Medline, Cochrane, Scopus, and Web of Science databases from inception to March 2022;13 studies covering 84 003 prostate cancer (PCa) patients with or without ADT met the eligibility criteria and were included in the meta-analysis. We calculated the pooled risk ratios (RRs) with 95% confidence intervals (CIs) to explore the association between ADT use and the infection risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and severity of COVID-19. After synthesizing the evidence, the pooled RR in the SARS-CoV-2 positive group was equal to 1.17, and the SARS-CoV-2 positive risk in PCa patients using ADT was not significantly different from that in those not using ADT (P = 0.544). Moreover, no significant results concerning the beneficial effect of ADT on the rate of intensive care unit admission (RR = 1.04, P = 0.872) or death risk (RR = 1.23, P = 0.53) were found. However, PCa patients with a history of ADT use had a markedly higher COVID-19 hospitalization rate (RR = 1.31, P = 0.015) than those with no history of ADT use. These findings indicate that ADT use by PCa patients is associated with a high risk of hospitalization during infection with SARS-CoV-2. A large number of high quality studies are needed to confirm these results.

2.
Transactions in Gis ; : 18, 2022.
Article in English | Web of Science | ID: covidwho-1677371

ABSTRACT

Monitoring the resumption of work and production (RWP) is of great significance to the restoration of social order and the economy after the coronavirus disease 2019 (COVID-19) epidemic. In this study, the most critical period of epidemic prevention and control and economic recovery was divided into four phases according to the changes in emergency response levels during the epidemic in China, and based on VIIRS I-Band 375-m active fire data (VNP14IMG), NO2 tropospheric vertical column density (TVCD) data, and intracity travel intensity data, the density-based spatial clustering of applications with the noise logistic regression industrial heat source identification model, NO2 difference model, and urban relative recovery index were constructed to analyze work resumption at different phases. The results indicate that: (1) the production intensity of China's heat source enterprises decreased first and then exceeded the epidemic period compared with the same period in history. From phases 1 to 3, the heat source enterprise production intensity was lower than the same period in 2019 (the production intensities were 19,562.79, 22,462.57, and 38,466.89, respectively), and the reduction rates of production intensity were 27.5, 26.1, and 22.7%, respectively. In phase 4, enterprise production intensity achieved an increase of 7%. (2) The process of the RWP in China is closely related to NO2 TVCD. In the first three phases, significantly decreased emission sources of NO2 reduced the total value of NO2 by varying degrees in most provinces of the country. Correspondingly, in phase 4, the NO2 TVCD in some provinces recovered to the value of the same period in 2019, including typical industrial bases (Shandong, Hebei, Shanxi, etc.) and economically developed coastal areas (Jiangsu, Guangdong, Zhejiang, etc.). (3) In phase 3, the intracity travel intensity in all cities improved, and the city relative recovery index (RRI) rose across the board. In particular, the western cities were better than the eastern cities. Among them, the RRIs of most cities in southwest China (Sichuan, Yunnan) and northwest China (Gansu) were more than 90%. Notably, the recovery situation exhibited an obvious "siege phenomenon," and the recovery of core cities required a longer period. Overall, the sudden COVID-19 epidemic seriously affected the production of Chinese enterprises. However, benefitting from rapid and effective epidemic prevention and control measures, the resumption of work and production has been a success. Our study provides guidance for economic recovery strategies during post-pandemic stages.

3.
Frontiers in Energy Research ; 9:9, 2021.
Article in English | Web of Science | ID: covidwho-1365538

ABSTRACT

China's Belt and Road (B&R) initiative provides new ideas and opportunities for international cooperation. Renewable energy plays a crucial role not only in the national sustainable development framework of China and the Philippines but also in bilateral cooperation between them. However, some obstacles still need to be addressed because renewable energy cooperation between China and the Philippines has not been thoroughly and comprehensively studied to date. Based on an in-depth analysis of current renewable energy cooperation between China and the Philippines, this paper employs PESTEL analysis to fully investigate the cooperative advantages and disadvantages by considering politics (P), economy (E), society (S), technology (T), environment (E), and legislation (L) and proposes several constructive suggestions. The ultimate purpose was to design feasible schemes to ensure the sufficient utilization of renewable energy and the construction of integrated power grid systems to meet shortages of electricity supply especially in the isolated small islands in the Philippines through cooperation with China. In particular, it offers valuable advice concerning the U.S.-China trade war and COVID- 19 pandemic, outlining how cooperation in the exploitation of potential renewable energy is vital.

4.
Zhonghua Wei Chang Wai Ke Za Zhi ; 24(4): 359-365, 2021 Apr 25.
Article in Chinese | MEDLINE | ID: covidwho-827753

ABSTRACT

Objective: Pelvic high-resolution magnetic resonance imaging (MRI) has now become a standard method for evaluating the efficacy of neoadjuvant treatment for locally advanced rectal cancer (LARC). However, this traditional morphological qualitative assessment method based on T2-weighted imaging (T2WI) is not effective in predicting pathological complete remission (pCR). The purpose of this study is to investigate whether combining the magnetic resonance tumor regression grade (mrTRG) with apparent diffusion coefficient (ADC) can improve diagnostic value for pCR after preoperative neoadjuvant chemoradiotherapy (nCRT) of LARC. Methods: This was a diagnostic study. Clinicopathological data of 134 LARC patients who received nCRT and radical surgery in the First Affiliated Hospital of Kunming Medical University from January 2017 to December 2019 were retrospectively analyzed. All the patients underwent MRI which included T2WI and DWI sequences before and 8 weeks after nCRT. Two radiologists independently drew ROIs on T2WI and DWI to estimate mrTRG stage and calculate the mean ADC value. Receiver operating characteristics (ROC) method was applied to evaluate the predict value of mrTRG combined with mean ADC value for pCR. Results: Of 134 LARC patients, 85 were male and 49 were female with median age of 58 (28-82) years. After nCRT, MRI suggested 21 patients (15.7%) had clinical complete remission (cCR), e.g. mrTRG stage 1-2. Postoperative pathology revealed 31 (23.1%) patients had pCR. The evaluations of mrTRG and ADC value by the two readers were highly consistent, and the intra-group correlation coefficients were 0.83 (95% CI: 0.703-0.881) and 0.96 (95% CI: 0.989-0.996), respectively. There was a negative correlation between mrTRG and pCR (r(s)=-0.505, P<0.01), and a positive correlation between mean ADC value and pCR (r(s)=0.693, P<0.01). The ROC curve showed that mrTRG alone had a medium predictive value for pCR, with an area under the curve (AUC) of 0.832 (95% CI: 0.743-0.921); the mean ADC value had a higher predictive value for pCR, with AUC of 0.906 (95% CI: 0.869-0.962). The predictive value of the combined model of mrTRG and ADC value for pCR was significantly better than that of mrTRG alone (P=0.015), and the AUC was 0.908 (95% CI: 0.849-0.968). Conclusion: Both mrTRG and mean ADC value can be non-invasive methods to predict the efficacy of nCRT for LARC. Combining the mean ADC value with mrTRG can result in better pCR prediction.


Subject(s)
Neoadjuvant Therapy , Rectal Neoplasms , Aged , Aged, 80 and over , Chemoradiotherapy , Diffusion Magnetic Resonance Imaging , Female , Humans , Magnetic Resonance Imaging , Male , Middle Aged , Rectal Neoplasms/drug therapy , Rectal Neoplasms/therapy , Retrospective Studies , Treatment Outcome
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