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1.
Arch Virol ; 166(10): 2895-2899, 2021 Oct.
Article in English | MEDLINE | ID: covidwho-1415037

ABSTRACT

After the 2005-2009 chikungunya epidemic, intermittent outbreaks were reported in many parts of India. The outbreaks were caused by either locally circulating strains or imported viruses. Virus transmission routes can be traced by complete genome sequencing studies. We investigated two outbreaks in 2014 and 2019 in Kerala, India. Chikungunya virus (CHIKV) was isolated from the samples, and whole genomes were sequenced for a 2014 isolate and a 2019 isolate. Phylogenetic analysis revealed that the isolates formed a separate group with a 2019 isolate from Pune, Maharashtra, and belonged to the East/Central/South African (ECSA) genotype, Indian subcontinent sublineage of the Indian Ocean Lineage (IOL). A novel mutation at amino acid position 76 of the E2 gene was observed in the group. The phylogenetic results suggest that the outbreaks might have been caused by a virus that had been circulating in India since 2014. A detailed study is needed to investigate the evolution of CHIKV in India.


Subject(s)
Chikungunya Fever/epidemiology , Chikungunya Fever/virology , Chikungunya virus/genetics , Disease Outbreaks , Chikungunya Fever/transmission , Chikungunya virus/classification , Chikungunya virus/isolation & purification , Genome, Viral/genetics , Genotype , Humans , India/epidemiology , Mutation , Phylogeny , RNA, Viral/genetics , Viral Envelope Proteins/genetics
2.
Arthrosc Sports Med Rehabil ; 3(4): e1141-e1146, 2021 Aug.
Article in English | MEDLINE | ID: covidwho-1225127

ABSTRACT

PURPOSE: The purpose of this study is to determine the safety of elective, outpatient orthopaedic sports procedures during the Coronavirus (COVID-19) pandemic at a high-volume orthopaedic practice. METHODS: All patients who were scheduled for elective, outpatient orthopaedic sports medicine procedures at 1 of 2 of outpatient surgical centers between July 1, 2020, and December 31, 2020, were asked to complete a custom survey during a postoperative clinic visit or phone call at a minimum of 2 weeks or were subject to a routine screening questionnaire and temperature screening at the time of the first postoperative follow-up visit. The survey questionnaire assessed for any COVID-19-related symptoms. Surgical case logs were retrieved to review for any cancelled surgeries due to a positive preoperative COVID-19 test. RESULTS: In total, 3.5% of patients (n = 39/1119) scheduled for surgery were diagnosed with COVID-19 during preoperative testing, resulting in surgical cancellation. Patients with a positive preoperative COVID-19 test result were found to be significantly younger (46 ± 20 years) when compared to all other patients with a negative test (51 ± 21 years; P = .002). No patient was diagnosed with COVID-19, reported symptoms concerning for COVID infection, underwent additional testing, or reported close contact with another individual with a positive test or possessed symptoms concerning for COVID-19 at a minimum of 2 weeks after surgery. CONCLUSION: This study found that 3.5% of patients tested positive for COVID-19 and were significantly younger when compared with patients testing negative. No patient investigated for potential infection after surgery reported the development of any symptoms related to COVID-19 or reported a positive test result after surgery. Using current protocols for preoperative screening, elective outpatient orthopaedic surgery performed in an Ambulatory Surgical Center is safe with no documented cases of COVID-19 transmission in this cohort. LEVEL OF EVIDENCE: Level IV, prognostic case series.

3.
2020 International Conference for Emerging Technology, INCET 2020 ; 2020.
Article in English | Scopus | ID: covidwho-1017122

ABSTRACT

The recent spread of COVID-19, stressed economies and government pumping money into the market has once again ignited the discussion on the need to have decentralised economies, the role of regulatory authorities and if bitcoin represents a true store of value. In this paper, we identify the need to alternate financial structure, discuss how blockchain and cryptocurrencies play a very important role in achieving it. Blockchain applications are heavily dependent on oracles for their interaction with outside world, we have discussed here the functioning of oracles and then finally presented a broad architecture that can be used to implement a majority of financial instruments on blockchain. © 2020 IEEE.

4.
Respir Med Case Rep ; 31: 101214, 2020.
Article in English | MEDLINE | ID: covidwho-752896

ABSTRACT

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the novel coronavirus initially detected in Wuhan, China, and is responsible for the worldwide pandemic coronavirus disease 2019 (Covid-19). Influenza is a common endemic respiratory virus that causes seasonal outbreaks of respiratory illness. There are currently few reports in the literature describing patients with coexisting infections. This case series of 4 patients identified at our single institution in Louisiana highlights the patient characteristics, laboratory findings, and outcomes in patients with both Covid-19 and influenza infection.

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