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Clinics (Sao Paulo, Brazil) ; 2022.
Article in English | EuropePMC | ID: covidwho-2033945
Vaccines ; 10(9):1504, 2022.
Article in English | MDPI | ID: covidwho-2010369


Several vaccines against COVID-19 are now available, based on different techniques and made by different laboratories spread around the world. With the roll out of the vaccination process in an advanced stage in many countries, the reduced risk of hospitalization due to the Omicron variant relative to the Delta variant infection, despite the higher transmission risk of Omicron, may lead to a misinterpretation of the results, as infection by Omicron is associated with a significant reduction in severe outcomes and shorter hospitalization time than the Delta variant. We compared the in-hospital mortality due to the Omicron (Jan–Mar 2022) with Gamma (Jan 2021) and Delta (Oct–Dec 2021) variants of patients in the Brazilian public health system. This study also discusses the decrease in booster vaccine effectiveness in patients hospitalized due to the Omicron variant compared with the Delta variant. Without a remodeling of vaccines for new variants, booster doses may be necessary with a shorter time interval.

Eur J Neurol ; 2022 Aug 16.
Article in English | MEDLINE | ID: covidwho-1992779
J Child Neurol ; : 8830738221114492, 2022 Jul 25.
Article in English | MEDLINE | ID: covidwho-1956985
Ann Med Surg (Lond) ; 78: 103951, 2022 Jun.
Article in English | MEDLINE | ID: covidwho-1944151
Ann Med Surg (Lond) ; 80: 104181, 2022 Aug.
Article in English | MEDLINE | ID: covidwho-1936025
Neuropsychiatric disease and treatment ; 18:1273-1275, 2022.
Article in English | EuropePMC | ID: covidwho-1918635
Int J Infect Dis ; 122: 443, 2022 Jun 26.
Article in English | MEDLINE | ID: covidwho-1914473
Clinics (Sao Paulo) ; 77: 100064, 2022 Jun 13.
Article in English | MEDLINE | ID: covidwho-1885698


Guillain-Barre Syndrome (GBS) has been repeatedly reported as a neurological complication of COVID-19 (post-COVID GBS [PCG]). Whether the introduction of SARS-CoV-2 vaccines reduced the prevalence of PCG is unknown. This narrative review aimed to compare the number of published PCG cases between the second half of 2020 (no vaccination available) with those of the first half of 2021 (vaccination available). A total of 124 articles reported 300 patients with PCG between January 2020 and June 2021. The ages ranged from 7 to 94y. There was male dominance. The latency between the onset of COVID-19 and the onset of PCG ranged from -10 to 90d Acute, inflammatory, demyelinating polyneuropathy was diagnosed in 171 patients, acute, motor axonal neuropathy in 24, and acute, motor, and sensory axonal neuropathy in 16 patients. Regarding treatment, 241 patients received immunoglobulins, 28 patients' plasmaphereses, and 7 patients' steroids. Artificial ventilation was required in 59 patients. Full recovery was achieved in 42 cases, partial recovery in 163 cases, and 17 patients died. The number of published PCG patients fell from 192 in the second half of 2020 to 75 patients in the first half of 2021. It is concluded that the prevalence of PCG has decreased since the introduction of SARS-CoV-2 vaccines. SARS-CoV-2 vaccinations have a positive effect on the prevalence of PCG.

Ann Med Surg (Lond) ; 78: 103875, 2022 Jun.
Article in English | MEDLINE | ID: covidwho-1866832
Neurol Res Pract ; 4(1): 10, 2022 Mar 21.
Article in English | MEDLINE | ID: covidwho-1841091


In this letter we raise several concerns regarding the interesting article by Walter and Krämer about rhomb-encephalitis as a complication two months after the vaccination with an mRNA-based SARS-CoV_2 vaccine. The causal link between the vaccination and encephalitis remained unproven, a SARS-CoV-2 infection, Bickerstaff encephalitis were not excluded, the MRI rather suggests brainstem-encephlaitis than pure rhomb-encephalitis, and the cerebro-spinal fluid was not investigated for cytokines or glial markers. Neurologists are called to make all available effort to convincingly evaluate the etiology and the pathophysiological background of an undetermined condition.

Ann Med Surg (Lond) ; 77: 103662, 2022 May.
Article in English | MEDLINE | ID: covidwho-1800207
PLoS One ; 17(3): e0262433, 2022.
Article in English | MEDLINE | ID: covidwho-1731594


We report strong evidence of the importance of contact hubs (or superspreaders) in mitigating the current COVID-19 pandemic. Contact hubs have a much larger number of contacts than the average in the population, and play a key role on the effectiveness of vaccination strategies. By using an age-structures compartmental SEIAHRV (Susceptible, Exposed, Infected symptomatic, Asymptomatic, Hospitalized, Recovered, Vaccinated) model, calibrated from available demographic and COVID-19 incidence, and considering separately those individuals with a much greater number of contacts than the average in the population, we show that carefully choosing who will compose the first group to be vaccinated can impact positively the total death toll and the demand for health services. This is even more relevant in countries with a lack of basic resources for proper vaccination and a significant reduction in social isolation. In order to demonstrate our approach we show the effect of hypothetical vaccination scenarios in two countries of very different scales and mitigation policies, Brazil and Portugal.

COVID-19 Vaccines/administration & dosage , COVID-19/prevention & control , Models, Theoretical , Brazil , COVID-19/transmission , COVID-19/virology , Humans , Portugal , SARS-CoV-2/isolation & purification , Vaccination
Rev Soc Bras Med Trop ; 55: e0381, 2022.
Article in English | MEDLINE | ID: covidwho-1724994

COVID-19 , Humans , SARS-CoV-2