Assessing the Future City Post COVID-19: Linking the SDGs, Health, Resilience, and Psychological Impact

This paper explores how the COVID-19 pandemic has affected progress toward urban sustainability. A methodological framework was developed as an integrated-assessment tool for future cities, triangulating indicators that are relevant to cities. The development of this framework was based on understanding the dimensions of sustainable cities and factors related to the urgent crises, and the related lifestyle and psychological factors. The study focuses on the SDGs and health and resilience requirements and links them with the behavioral changes resulting from the COVID-19 pandemic. This paper builds on the advantages of various methodological frameworks by integrating their respective approaches, to offer a more comprehensive solution. A series of measures and actions (scenarios) related to sustainable cities and pandemics are discussed. This approach involves developing relevant indicators by fitting the urban health and resilience goals to the social, economic, and environmental goals of sustainable cities, as well as considering the factors affecting people's perception of cities during and after the pandemic. The paper provides insights into how future cities could be planned, designed, and governed to reduce the impact of health crises and to enable the assessment of cities in relation to the chosen dimensions (health, resilience, sustainability, human). © 2023 by the authors.

Microplastics in the Ecosystem: An Overview on Detection, Removal, Toxicity Assessment, and Control Release

In recent decades, the accumulation and fragmentation of plastics on the surface of the planet have caused several long-term climatic and health risks. Plastic materials, specifically microplastics (MPs;sizes < 5 mm), have gained significant interest in the global scientific fraternity due to their bioaccumulation, non-biodegradability, and ecotoxicological effects on living organisms. This study explains how microplastics are generated, transported, and disposed of in the environment based on their sources and physicochemical properties. Additionally, the study also examines the impact of COVID-19 on global plastic waste production. The physical and chemical techniques such as SEM-EDX, PLM, FTIR, Raman, TG-DSC, and GC-MS that are employed for the quantification and identification of MPs are discussed. This paper provides insight into conventional and advanced methods applied for microplastic removal from aquatic systems. The finding of this review helps to gain a deeper understanding of research on the toxicity of microplastics on humans, aquatic organisms, and soil ecosystems. Further, the efforts and measures that have been enforced globally to combat MP waste have been highlighted and need to be explored to reduce its potential risk in the future. © 2022 by the authors.

Factors Influencing Access to Health Services among Chronically Ill Older Adults with Physical Disabilities in the Era of the COVID-19 Outbreak

Chronically ill older adults with physical disabilities frequently face difficulties in their daily lives and require essential health service access, especially in the COVID-19 context. This study aimed to examine the association between social support, perception of benefits due to disability and access to health services among chronically ill older adults with physical disabilities during this crisis in Thailand. A total of 276 chronically ill older adults with physical disabilities were included in this cross-sectional study. Self-reported questionnaires were assessed through multi-stage random sampling. Correlations between the independent variables and health service access were examined using multiple regression analysis. Of the respondents, 159 were female (59.6%). Most participants perceived benefits (58.8%) and access to health services (56.2%) at good levels, while social support was at a moderate level (47.9%). Stepwise multiple regression analysis showed that social support (β = 0.351), perception of benefits (β = 0.257) and age (β = 0.167) were positively correlated with health service access. The findings are relevant for health care providers and multi-professional teams, who should enhance older adults' social support and perception of benefits to improve their access to health services, particularly among chronically ill older adults with physical disabilities, in the era of COVID-19. © 2022 by the authors.

Highlights of the drug-induced liver injury literature for 2021.

INTRODUCTION: In 2021, over 3,000 articles on Drug-Induced Liver Injury (DILI) were published, nearly doubling the annual number compared to 2011. This review selected DILI articles from 2021 we felt held the greatest interest and clinical relevance. AREAS COVERED: A literature search was conducted using PubMed between 1 March 2021 and 28 February 2022. 86 articles were included. This review discusses new and established cases of hepatotoxins, including new FDA approvals and COVID-19 therapeutics. Developments in biomarkers and causality assessment methods are discussed. Updates from registries are also explored. EXPERT OPINION: DILI diagnosis and prognostication remain challenging. Roussel Uclaf Causality Assessment Method (RUCAM) is the best option for determining causality and has been increasingly accepted by clinicians. Revised Electronic Causality Assessment Method (RECAM) may be more user-friendly and accurate but requires further validation. Quantitative systems pharmacology methods, such as DILIsym, are increasingly used to predict hepatotoxicity. Oncotherapeutic agents represent many newly approved and described causes of DILI. Such hepatotoxicity is deemed acceptable relative to the benefit these drugs offer. Drugs developed for non-life-threatening disorders may not show a favorable benefit-to-risk ratio and will be more difficult to approve. As the COVID-19 landscape evolves, its effect on DILI deserves further investigation.