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Advances in Medicine and Biology ; 179:91-128, 2021.
Artículo en Inglés | Scopus | ID: covidwho-1469206


Hemophagocytic lymphohistiocytosis (HLH) is a syndrome characterized by an uncontrolled inflammation, and hypercytokinemia as a result of uncontrolled activation of cytotoxic T cells and macrophages, resulting in the HLH classical symptoms such as: Persistent fever, hepatosplenomegaly, rash, cytopenias, hemophagocytosis, hyperferritine-mia, hypertriglyceridemia and central nervous system infiltration. Patients can develop coagulopathy, liver failure and progress to multi-organ failure with high mortality rates. HLH is classified as primary when it is associated with a familial, inherited factor whereas it is secondary when associated with a non-inherited factor. Evidence supports that infections can trigger the physiopathology of HLH. The most common viral infections are;cytomegalovirus and Epstein Barr however, other viruses such as dengue, HIV and more recently, the acute respiratory distress syndrome induced by SARS-CoV2 have been identified as infections associated with HLH (iHLH). The link between viral infection and immunoreactivity is well recognized, however, the mechanism in which the viruses are involved in the development of HLH remains unclear. In this chapter we discuss the role of the viral infection and some features from the host which takes part in the development of HLH. © 2021 by Nova Science Publishers, Inc. All rights reserved.