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1.
Pharmaceutical Journal ; 308(7958), 2022.
Artigo em Inglês | EMBASE | ID: covidwho-2032639
2.
Pharmaceutical Journal ; 308(7958), 2022.
Artigo em Inglês | EMBASE | ID: covidwho-2032638
3.
Pharmaceutical Journal ; 308(7957), 2022.
Artigo em Inglês | EMBASE | ID: covidwho-2032637
4.
Pharmaceutical Journal ; 308(7957), 2022.
Artigo em Inglês | EMBASE | ID: covidwho-2032636
5.
Pharmaceutical Journal ; 308(7957), 2022.
Artigo em Inglês | EMBASE | ID: covidwho-2032633
6.
Pharmaceutical Journal ; 308(7957), 2022.
Artigo em Inglês | EMBASE | ID: covidwho-2032629
7.
International Journal of Sport and Society ; 13(1):111-126, 2022.
Artigo em Inglês | Scopus | ID: covidwho-2026001

RESUMO

In a population of youth affiliated with a large Sport for Development facility in downtown Toronto, physical activity (PA) levels declined dramatically at the outset of the COVID-19 pandemic and remained inadequate a year later. Daily PA increased significantly over time, H(10) = 35.506, p < .01, but remained well below the recommended benchmarks for the accrual of positive health and wellness-related outcomes. During the first six months of the pandemic, respondents participating in virtual sport and physical activity programs offered by the facility were significantly more physically active than respondents not participating, H(1) = 8.327, p < .01, with the greatest difference between the two groups seen in May 2020. A larger percentage of individuals maintained adequate levels of PA during the pandemic compared to Canada’s general population of children and youth. These findings are consistent with evidence indicating a strong influence of built environment and other socioeconomic factors on movement behavior among children and youth during the COVID-19 pandemic and provide a unique narrative reflecting the experience of urban youth facing barriers to positive development in Canada’s largest city. © Common Ground Research Networks, Marika Warner, Jackie Robinson, Jennifer Lloyd, Some Rights Reserved.

8.
Infection ; 2022.
Artigo em Inglês | Web of Science | ID: covidwho-2014586

RESUMO

PURPOSE: The objective of this study was to describe the clinical course and outcomes in children with technology dependence (TD) hospitalized with SARS-CoV-2 infection. METHODS: Seventeen pediatric hospitals (15 Canadian and one each in Iran and Costa Rica) included children up to 17 years of age admitted February 1, 2020, through May 31, 2021, with detection of SARS-CoV-2. For those with TD, data were collected on demographics, clinical course and outcome. RESULTS: Of 691 children entered in the database, 42 (6%) had TD of which 22 had feeding tube dependence only, 9 were on supplemental oxygen only, 3 had feeding tube dependence and were on supplemental oxygen, 2 had a tracheostomy but were not ventilated, 4 were on non-invasive ventilation, and 2 were on mechanical ventilation prior to admission. Three of 42 had incidental SARS-CoV-2 infection. Two with end-stage underlying conditions were transitioned to comfort care and died. Sixteen (43%) of the remaining 37 cases required increased respiratory support from baseline due to COVID-19 while 21 (57%) did not. All survivors were discharged home. CONCLUSION: Children with TD appear to have an increased risk of COVID-19 hospitalization. However, in the absence of end-stage chronic conditions, all survived to discharge.

9.
Lancet Planet Health ; 6(9):e769-73, 2022.
Artigo em Inglês | PMC | ID: covidwho-2008223

RESUMO

COVID-19 has devastated global communities and economies. The pandemic has exposed socioeconomic disparities and weaknesses in health systems worldwide. Long-term health effects and economic recovery are major concerns. Ecosystem restoration—ie, the repair of ecosystems that have been degraded—relates directly to tackling the health and socioeconomic burdens of COVID-19, because stable and resilient ecosystems are fundamental determinants of health and socioeconomic stability. Here, we use COVID-19 as a case study, showing how ecosystem restoration can reduce the risk of infection and adverse sequelae and have an integral role in humanity's recovery from COVID-19. The next decade will be crucial for humanity's recovery from COVID-19 and for ecosystem repair. Indeed, in the absence of effective, large-scale restoration, 95% of the Earth's land could be degraded by 2050. The UN Decade on Ecosystem Restoration (2021–30) declaration reflects the growing urgency and scale at which we should repair ecosystems. Importantly, ecosystem restoration could also help to combat the health and socioeconomic issues that are associated with COVID-19, yet it is poorly integrated into current responses to the disease. Ecosystem restoration can be a core public health intervention and assist in COVID-19 recovery if it is closely integrated with socioeconomic, health, and environmental policies.

10.
Smart Biomedical and Physiological Sensor Technology Xix ; 12123, 2022.
Artigo em Inglês | Web of Science | ID: covidwho-2005293

RESUMO

Accumulating evidence suggests that cytokine storm syndrome (CSS) induced by the SARS-CoV-2 may be the ultimate cause of acute respiratory distress syndrome (ARDS), resulting in severe outcomes of COVID- 19 infection and potentially death. Elevated levels of serum interleukin 6 (IL-6) correlate with the occurrence of respiratory failure, ARDS, and adverse clinical outcomes in many COVID-19 patients. The currently available clinical cytokine tests are costly, time-consuming, and require skilled technicians to execute. There is an unmet need for rapid, affordable, robust, and sensitive tests for cytokine levels. Therefore, this study aimed to develop a cost-effective system for quantitative detection of cytokines that can be used in the point-of-care (POC) format within a few minutes of blood collection. Our approach combines detection based on laser-induced breakdown spectroscopy with a lateral flow immunoassay (LIBS- LFIA) to deliver a quantitative clinical analysis platform with multiplexing capability. Lanthanide-complexed polymers (LCPs) were selected as the labels to provide optimal quantitative performance when sensing signals from the test lines of LFIAs. For a prototype implementation and a proof-of-concept, we targeted IL-6 as it is one of the most critical pro-inflammatory cytokines. Our initial LIBS-LFIA biosensor achieved a limit of detection ( LOD) of 0.2298 mu g/mL of IL-6 within 15 minutes and further sensitivity increase is possible with optimization. Regardless, since high levels of IL-6 are reported for patients in crisis, this is more than adequate to identify patients with highly elevated cytokine levels. Our research provides evidence that rapid and accurate detection of cytokines for clinical diagnosis and prognosis of COVID-19 and other pathogenic infections using LIBS is highly feasible and compatible with the POC format.

11.
European journal of preventive cardiology ; 29(Suppl 1), 2022.
Artigo em Inglês | EuropePMC | ID: covidwho-1999156

RESUMO

Funding Acknowledgements Type of funding sources: Public Institution(s). Main funding source(s): University of British Columbia Clinician Investigator Program Background The COVID-19 pandemic resulted in the abrupt suspension of centre-based cardiac rehabilitation (CR). Multidisciplinary virtual CR (VCR) with the use of digital, telephone, and video communication was implemented for continued care access. Exercise therapy was delivered through synchronous video-supervised sessions, pre-recorded sessions, and self-directed physical activity. Purpose To describe patient characteristics, completion rates, and safety outcomes in a real-world VCR population. Methods Prospective observational study of a tertiary academic CR program. VCR was implemented at pandemic onset (March 2020). Patients who were enrolled in, and either completed or dropped out, during the study period were included. Completers were defined as completing 6 months of virtual enrolment and an exit assessment. Risk was defined by the AACPVR 2020 risk categorization. Adverse cardiovascular events were defined as a patient-initiated event requiring medical assessment and stratified as exercise or non-exercise related. Continuous variables are presented as means and SD or medians and IQR. Student’s t-test was used for between group comparisons. Categorical variables are presented as n (%) and compared using the χ2 test or Fischer’s exact test. A p-value <0.05 was considered significant. Results Between March 13th, 2020, and August 31st, 2021, 222 [mean age 61.8 years (SD, 12.6) 77% male], were enrolled and discharged from the VCR program (Table 1). There were 160 completers and 62 non-completers (completion rate 72%). Among the non-completers 26 attended the MD intake assessment only. The remaining 36 completed a median of 85 days (IQR 25-197). This cohort included 21 (9%) high-risk and 35 (16%) moderate risk patients. Those at moderate risk were more likely to be non-completers and those at low risk were more likely to be completers (Table 1). Two exercise and 17 non-exercise adverse events were observed (median clinical surveillance 217 days [IQR 205-240]) (Table 2). Exercise related adverse events included neurally mediated syncope during a synchronous video exercise session in a low risk patient. This was responded to as per centre developed virtual safety protocols. A second syncope related to heart block occurred in a moderate risk patient during independent physical activity and required permanent pacemaker insertion. Both patients completed the program. Three non-exercise adverse cardiac events resulted in cessation of participation included one death and two heart failure hospitalizations (Table 2). One stroke and 13 emergency department visits for cardiac symptoms occurred in completers. Conclusion Real world VCR is feasible, including in those at moderate to high risk. Modest completion rates and a low exercise related adverse event rate were observed. Synchronous video exercise sessions with video monitoring and safety protocols may improve response to adverse exercise related events. Table 1 Table 2

12.
Journal of Business and Educational Leadership ; 12(1):35-56, 2022.
Artigo em Inglês | ProQuest Central | ID: covidwho-1970498

RESUMO

Keywords: Online Learning, Professionalism, Student Development, Online Classroom Management, Distance Learning INTRODUCTION In higher education, distance education or online courses are terms describing instruction and evaluation of students who are geographically separated from the instructor. While Shea and Bidjerano (2009) examined the relationship between community of inquiry, instructional design and content delivery in online learning and student cognitive and social presence, the current work expands on the premise to move beyond technical/design conversations to address online student engagement and learning as it influences professional development. Though traditional on-site classroom activities include group student to student activities and substantial interaction with faculty members, the figure highlights the student independence afforded in an online classroom, distant from faculty and other students. According to Morrow, systems may politicize and delegitimize educational achievement by wrongfully addressing the ills of contemporary life and its dogma by a required response from educational institutions to support society's evolution by changing their academic qualifications. [...]a change in culture can invert the burden of responsibility so the student cannot be blamed for the lack of

13.
Clin Infect Dis ; 2022 May 17.
Artigo em Inglês | MEDLINE | ID: covidwho-1927307

RESUMO

BACKGROUND: The efficacy of SARS-CoV-2 convalescent plasma (CCP) for preventing infection in exposed, uninfected individuals is unknown. CCP might prevent infection when administered before symptoms or laboratory evidence of infection. METHODS: This double-blinded, phase 2 randomized, controlled trial (RCT) compared the efficacy and safety of prophylactic high titer (≥1:320 by Euroimmun ELISA) CCP with standard plasma. Asymptomatic participants aged ≥18 years with close contact exposure to a person with confirmed COVID-19 in the previous 120 hours and negative SARS-CoV-2 test within 24 hours before transfusion were eligible. The primary outcome was new SARS-CoV-2 infection. RESULTS: 180 participants were enrolled; 87 were assigned to CCP and 93 to control plasma, and 170 transfused at 19 sites across the United States from June 2020 to March 2021. Two were excluded for screening SARS-CoV-2 RT-PCR positivity. Of the remaining 168 participants, 12/81 (14·8%) CCP and 13/87 (14·9%) control recipients developed SARS-CoV-2 infection; 6 (7·4%) CCP and 7 (8%) control recipients developed COVID-19 (infection with symptoms). There were no COVID-19-related hospitalizations in CCP and 2 in control recipients. Efficacy by restricted mean infection free time (RMIFT) by 28 days for all SARS-CoV-2 infections (25·3 vs. 25·2 days; p = 0·49) and COVID-19 (26·3 vs. 25·9 days; p = 0·35) was similar for both groups. CONCLUSIONS: Administration of high-titer CCP as post-exposure prophylaxis, while appearing safe, did not prevent SARS-CoV-2 infection.

14.
Sleep ; 45(SUPPL 1):A92, 2022.
Artigo em Inglês | EMBASE | ID: covidwho-1927393

RESUMO

Introduction: There is growing evidence that insufficient sleep can negatively impact the immune system, including vaccination response. Prior laboratory studies have shown that acute sleep restriction can result in impaired antibody resposne to the hepatitis A and influenza vaccine. Similarly, prospective studies have shown that short sleep duration, measured by self-report and wrist actigraphy, is associated with muted antibody responses. These prior findings have critical implications for the COVID-19 pandemic and the efficacy and durability of the COVID-19 vaccines currently available. Whether sleep accounts for variability in response to the COVID- 19 vaccination series has not been investigated. Methods: We recruited 530 healthy participants (mean age= 52.4, SD=12.1, range: 18-88 years;64.1% female) who were naive to the COVID-19 vaccination series. Participants completed self-report questionaires (e.g., Pittsburgh Sleep Quality Index) and morning sleep diaries for 7-consecutive days surrounding COVID-19 vaccine administrations. Additionally, 198 participants wore a sleep tracking device (Oura ring) continuously for ~2 months beginning prior to vaccination, which provides behavioral sleep data on days prior to and following the COVID-19 vaccination series. Blood samples were collected prior to vaccination, +1 month after their final vaccine shot (peak response), and +6 months after their final vaccine shot (maintenance);neutralization assays using pseudotype virus will be carried out to quantify antibody titers. Results: Data collection concludes December 2021, with antibody assays to be completed February 2022. Initial baseline data indicates that most participants reported poor overall global sleep quality (PSQI mean=6.3, SD=3.6;52% PSQI>5). Linear mixed models will be conducted to test associations between habitual sleep duration (averaged over the measurement time points), sleep efficiency, and subjective sleep quality with antibody responses over time. Additionally, we will report on the relevance of sleep timing (midpoint) and vaccination timing (receiving the vaccine in the morning vs afternoon vs evening), and the role of self-reported sleep disorders (e.g., obstructive sleep apnea) and shift worker status. Covariates in these analyses will include age, gender, race, body mass index, prior COVID infection, and vaccine type (Moderna, Pfizer, Johnson and Johnson). Conclusion: These analyses will provide new knowledge about the role of sleep in mounting and maintaining antibody response to the COVID-19 vaccination series. These findings may provide novel insights into when and for whom improvements in sleep may result in better vaccine efficacy.

15.
European Journal of Preventive Cardiology ; 29(SUPPL 1):i315-i317, 2022.
Artigo em Inglês | EMBASE | ID: covidwho-1915592

RESUMO

Background: The COVID-19 pandemic resulted in the abrupt suspension of centre-based cardiac rehabilitation (CR). Multidisciplinary virtual CR (VCR) with the use of digital, telephone, and video communication was implemented for continued care access. Exercise therapy was delivered through synchronous video-supervised sessions, pre-recorded sessions, and self-directed physical activity. Purpose: To describe patient characteristics, completion rates, and safety outcomes in a real-world VCR population. Methods: Prospective observational study of a tertiary academic CR program. VCR was implemented at pandemic onset (March 2020). Patients who were enrolled in, and either completed or dropped out, during the study period were included. Completers were defined as completing 6 months of virtual enrolment and an exit assessment. Risk was defined by the AACPVR 2020 risk categorization. Adverse cardiovascular events were defined as a patient-initiated event requiring medical assessment and stratified as exercise or non-exercise related. Continuous variables are presented as means and SD or medians and IQR. Student's t-test was used for between group comparisons. Categorical variables are presented as n (%) and compared using the χ2 test or Fischer's exact test. A p-value <0.05 was considered significant. Results: Between March 13th, 2020, and August 31st, 2021, 222 [mean age 61.8 years (SD, 12.6) 77% male], were enrolled and discharged from the VCR program (Table 1). There were 160 completers and 62 non-completers (completion rate 72%). Among the non-completers 26 attended the MD intake assessment only. The remaining 36 completed a median of 85 days (IQR 25-197). This cohort included 21 (9%) high-risk and 35 (16%) moderate risk patients. Those at moderate risk were more likely to be non-completers and those at low risk were more likely to be completers (Table 1). Two exercise and 17 non-exercise adverse events were observed (median clinical surveillance 217 days [IQR 205-240]) (Table 2). Exercise related adverse events included neurally mediated syncope during a synchronous video exercise session in a low risk patient. This was responded to as per centre developed virtual safety protocols. A second syncope related to heart block occurred in a moderate risk patient during independent physical activity and required permanent pacemaker insertion. Both patients completed the program. Three non-exercise adverse cardiac events resulted in cessation of participation included one death and two heart failure hospitalizations (Table 2). One stroke and 13 emergency department visits for cardiac symptoms occurred in completers. Conclusion: Real world VCR is feasible, including in those at moderate to high risk. Modest completion rates and a low exercise related adverse event rate were observed. Synchronous video exercise sessions with video monitoring and safety protocols may improve response to adverse exercise related events. (Table Presented).

18.
Research Series Arkansas Agricultural Experiment Station ; 680:13-18, 2021.
Artigo em Inglês | CAB Abstracts | ID: covidwho-1871631

RESUMO

The Soybean Science Challenge (SSC) continues to support Arkansas STEM (science, technology, engineering, and mathematics) educational goals, is aligned with the Next Generation Science Standards (NGSS) and engages junior high and high school students in active learning and the co-creation of knowledge through support of classroom-based lessons and applied student research. The SSC educates and engages junior high and high school science students and teachers in 'real-world' Arkansas specific soybean science education through original NGSS aligned curriculum in 7E and Gathering Reasoning and Communicating (GRC)-3D format and a continuum of educational methods which include: teacher workshops, online and virtual education, NGSS aligned mini-lessons for science classrooms, community gardens, personal mentoring, student-led research and corresponding award recognition, and partnerships with state and national educators, agencies, and the popular media. The COVID-19 global pandemic altered the educational landscape in 2020 and continues to do so. The new educational environment has seen an increase in virtual classrooms, online courses, and interactions with Zoom © . The Soybean Science Challenge (SSC), by nature of its existing design and methodology, was and is amid these methods by launching online Next Generation Science Standards (NGSS) aligned Gathering Reasoning and Communicating (GRC)-3D and 7E lesson plans for teachers, adding an online course, adding NGSS aligned mini-lesson videos for the science classroom, and adding virtual field trips to the list on the Soybean Science Challenge website. The Challenge also sponsored the virtual Arkansas Science Teacher Association Conference, and the SSC Coordinator taught virtual workshops on bringing agriculturally based lessons into science classrooms. The Soybean Science Challenge virtually judged participants at both the regional and state level, and SSC added a junior level award at regional science fairs. Through the SSC, teachers now have access to a plethora of educational instructions that bring real-world agricultural critical thinking both into the classroom and the homes of students.

19.
Embase; 2021.
Preprint em Inglês | EMBASE | ID: ppcovidwho-337394

RESUMO

Spillover of sarbecoviruses from animals to humans has resulted in outbreaks of severe acute respiratory syndrome SARS-CoVs and the ongoing COVID-19 pandemic. Efforts to identify the origins of SARS-CoV-1 and -2 has resulted in the discovery of numerous animal sarbecoviruses - the majority of which are only distantly related to known human pathogens and do not infect human cells. The receptor binding domain (RBD) on sarbecoviruses engages receptor molecules on the host cell and mediates cell invasion. Here, we tested the receptor tropism and serological cross reactivity for RBDs from two sarbecoviruses found in Russian horseshoe bats. While these two viruses are in a viral lineage distinct from SARS-CoV-1 and -2, one virus, Khosta-2, was capable of using human ACE2 to facilitate cell entry. Viral pseudotypes with a recombinant, SARS-CoV-2 spike encoding for the Khosta 2 RBD were resistant to both SARS-CoV-2 monoclonal antibodies and serum from individuals vaccinated for SARS-CoV-2. Our findings further demonstrate that sarbecoviruses circulating in wildlife outside of Asia also pose a threat to global health and ongoing vaccine campaigns against SARS-CoV-2.

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