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1.
Cancer Research Conference: American Association for Cancer Research Annual Meeting, ACCR ; 83(7 Supplement), 2023.
Artigo em Inglês | EMBASE | ID: covidwho-20245083

RESUMO

Covid-19 virus variants identified so far are due to viral genetic diversity, genetic evolution, and variable infectivity, suggesting that high infection rates and high mortality rates may be contributed by these mutations. And it has been reported that the targeting strategies for innate immunity should be less vulnerable to viral evolution, variant emergence and resistance. Therefore, the most effective solution to Covid-19 infection has been proposed to prevent and treat severe exacerbation of patients with moderate disease by enhancing human immune responses such as NK cell and T cell. In previous studies, we demonstrated for the first time that gamma-PGA induced significant antitumor activity and antiviral activity by modulating NK cell-mediated cytotoxicity. Especially intranasal administration of gamma-PGA was found to effectively induce protective innate and CTL immune responses against viruses and we found out that gamma-PGA can be an effective treatment for cervical intraepithelial neoplasia 1 through phase 2b clinical trial. In this study, the possibility of gamma-PGA as a Covid-19 immune modulating agent was confirmed by animal experiments infected with Covid-19 viruses. After oral administration of gamma-PGA 300mug/mouse once a day for 5 days in a K18-hACE2 TG mouse model infected with SARS-CoV-2 (NCCP 43326;original strain) and SARS-CoV-2 (NCCP 43390;Delta variant), virus titer and clinical symptom improvement were confirmed. In the RjHan:AURA Syrian hamster model infected with SARS-CoV-2 (NCCP 49930;Delta variant), 350 or 550 mug/head of gamma-PGA was administered orally for 10 days once a day. The virus for infection was administered at 5 x 104 TCID50, and the titer of virus and the improvement of pneumonia lesions were measured to confirm the effectiveness in terms of prevention or treatment. In the mouse model infected with original Covid-19 virus stain, the weight loss was significantly reduced and the survival rate was also improved by the administration of gamma-PGA. And gamma-PGA alleviated the pneumonic lesions and reduced the virus titer of lung tissue in mice infected with delta variant. In the deltavariant virus infected hamster model, gamma-PGA showed statistically significant improvement of weight loss and lung inflammation during administration after infection. This is a promising result for possibility of Covid-19 therapeutics along with the efficacy results of mouse model, suggesting gammaPGA can be therapeutic candidate to modulate an innate immune response for Covid-19.

2.
1st Workshop on Natural Language Processing for Programming (NLP4Prog) ; : 125-134, 2021.
Artigo em Inglês | Web of Science | ID: covidwho-1456911

RESUMO

The ongoing COVID-19 pandemic resulted in significant ramifications for international relations ranging from travel restrictions, global ceasefires, and international vaccine production and sharing agreements. Amidst a wave of infections in India that resulted in a systemic breakdown of healthcare infrastructure, a social welfare organization based in Pakistan offered to procure medical-grade oxygen to assist India - a nation which was involved in four wars with Pakistan in the past few decades. In this paper, we focus on Pakistani Twitter users' response to the ongoing healthcare crisis in India. While #IndiaNeedsOxygen and #PakistanStandsWithIndia featured among the toptrending hashtags in Pakistan, divisive hashtags such as #EndiaSaySorryToKashmir simultaneously started trending. Against the back-drop of a contentious history including four wars, divisive content of this nature, especially when a country is facing an unprecedented healthcare crisis, fuels further deterioration of relations. In this paper, we define a new task of detecting supportive content and demonstrate that existing NLP for social impact tools can be effectively harnessed for such tasks within a quick turnaround time. We also release the first publicly available data set(1) at the intersection of geopolitical relations and a raging pandemic in the context of India and Pakistan.

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