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1.
Cardiovascular Therapy and Prevention (Russian Federation) ; 21(9):40-49, 2022.
Artigo em Russo | EMBASE | ID: covidwho-2164350

RESUMO

Aim. To assess the prevalence of non-alcoholic fatty liver disease (NAFLD) using the liver obesity index - FLI (Fatty Liver Index), and to study its associations with socio-demographic indicators and behavioral risk factors for NAFLD. Material and methods. The data from the multicenter ESSE-RF study (Epidemiology of cardiovascular diseases in the regions of the Russian Federation) - samples from the unorganized male and female population aged 25-64 years were used. 5,161 respondents were included, of which 2,275 (44,1%) were men. To assess the prevalence of NAFLD, the liver obesity index FLI was used, calculated according to the formula by Bedogni G, et al. (2006). A high FLI index =60 was considered a predictor of liver steatosis. Results. High FLI =60 was detected in 38,5% of men and 26,6% of women. Multivariate analysis of associations of high FLI index in men and women showed a strong relationship with age: men - odds ratio (OR) 5,01, 95% confidence interval (CI): 3,82-6,59 (p<0,0001) and women - OR 8,58, 95% CI: 6,39-11,64 (p<0,0001), living in rural areas: men - OR 1,32, 95% CI: 1,06-1,63 (p=0,011) and women - OR 1,4, 95% CI: 1,15-1,71 (p=0,001). The FLI index >=60 was significantly associated with low physical activity (p=0,001) in men and current smoking in women (p=0,013). Conclusion. A high FLI index >=60 is most common among men, significantly associated with age, living in rural areas, currently smoking women, and low physical activity men. Higher education, in relation to FLI >=60, had a protective effect on women. Copyright © 2022 Vserossiiskoe Obshchestvo Kardiologov. All rights reserved.

2.
2022 29th International Conference on Nuclear Engineering, ICONE 2022 ; 14, 2022.
Artigo em Inglês | Scopus | ID: covidwho-2161772

RESUMO

The development of nuclear energy, technology and applications programmes s creates a continuous need for a global workforce of highly qualified professionals with appropriate nuclear technical and managerial competence. The International Atomic Energy Agency (IAEA) provides the Nuclear Energy Management (NEM) School programme to help the Member States build and train future leaders in managing the national peaceful applications of nuclear science and technology. As the country with the fastest growth of nuclear energy in the world, China has a complete nuclear industrial chain, and the development of nuclear energy enjoys incomparable advantages. China cooperates with IAEA and holds the China-IAEA NEM School to share its experience and contribute its wisdom to the global nuclear energy development, and to personnel training of emerging nuclear energy countries. This paper reports a case study from the China-IAEA NEM School which investigates the joint cultivation and training mode for young professionals who show managerial potentiality and inherent ability for future leadership positions in the field of nuclear energy and technology in IAEA's Member States that plan to develop or are in the process of embarking upon a nuclear power programme. This study explores the school's training system which is reflected in different aspects, i.e. training format, curriculum, and lecturers. A questionnaire survey is also conducted to analyze trainees' evaluation of the school. The research findings are discussed in light of future developments and implications on young future leaders' cultivation and training in the nuclear field in post COVID era. Copyright © 2022 by ASME.

3.
Eye ; 08:08, 2022.
Artigo em Inglês | MEDLINE | ID: covidwho-2160201

RESUMO

PURPOSE: The aim of the study was to present the rates of corneal transplant rejection from 2018 to 2022 at both Moorfields Eye Hospital UK, and Ospedali Privati Forli (OPF) "Villa Igea", Italy and evaluate the purported association between COVID-19 vaccination and rejection.

6.
Extreme Medicine ; - (2):37-43, 2022.
Artigo em Inglês | Scopus | ID: covidwho-2146634

RESUMO

Establishing a link between the objective research data and the thought process is one of the major issues of modern neurophysiology. The study was aimed to find an opportunity to perform objective analysis of the causes of cognitive impairment in individuals having a history of mild novel coronavirus infection by solving the inverse EEG problem. A total of 38 COVID-19 survivors were assessed, who had returned to work. The control group included 33 healthy individuals. EEG was recorded using a 128-channel system with an average reference. The data obtained were subjected to the EEG microstate segmentation and converted using the algorithm for solving the inverse EEG problem implemented in the sLORETA software package. In individuals with no history of COVID-19 being in a state of relaxed wakefulness, the component of rhythmic activity within Brodmann area 47, responsible for perception and realization of music, was found in all classes of EEG microstates (0.01 < p < 0.05;χ2-test). Auditory-speech load was characterized by rhythmic activity within areas 22, 23, 37, 39, 40, 44, 45, and 47. In individuals having a history of novel coronavirus infection being in a state of relaxed wakefulness, rhythmic activity within areas 22, 37, 39, 40 was detected. Under auditory-speech load, there was rhythmic activity within areas 37, 39, and 41 (p < 0.05;χ2-test). Thus, alterations in realization of speech function in the form of the disordered sequence of switching on the main language centers were revealed in COVID-19 survivors. © 2022 Federal Medical Biological Agency Publishing Group. All Rights Reserved.

7.
Nevrologiya, Neiropsikhiatriya, Psikhosomatika ; 14(4):96-102, 2022.
Artigo em Russo | EMBASE | ID: covidwho-2145441

RESUMO

The pathogenesis of the development of cognitive impairment (CI) associated with the SARS-CoV-2 virus is complex and includes the direct neurotoxic effect of the virus, vascular, disimmune factors, artificial lung ventilation, and adverse psychological consequences of social isolation. The relationship between CI and SARS-CoV-2 infection appears to be two-way: patients with premorbid CI have a higher risk of infection, severe illness, and death;on the other hand, past infection with SARS-CoV-2 may stimulate the clinical onset and progression of CI, including Alzheimer's disease. For the treatment of severe CI after COVID-19, memantine (akatinol memantine) is recommended. Copyright © 2022 Ima-Press Publishing House. All rights reserved.

8.
Multiple Sclerosis Journal ; 28(3 Supplement):842-843, 2022.
Artigo em Inglês | EMBASE | ID: covidwho-2138807

RESUMO

Background: Patients on OCR have attenuated antibody, but largely intact T-cell responses to COVID-19 vaccination. Little is known about durability of post-vaccine responses in OCR-treated patients. Objective(s): To examine antibody and cellular responses to mRNA COVID-19 vaccines (Pfizer, BioNTech/Moderna) in Ocrelizumab (OCR)-treated MS patients over 24-week period. Method(s): MS patients on OCR were recruited from NYU (New York City) and Rocky Mountain at CU (Denver) MS Centers. Antibody responses to SARS-CoV-2 spike proteins were assessed with multiplex bead-based (MBI) immunoassays, and cellular responses to SARS-CoV-2 Spike protein with ELISpot and activation induced marker (AIM) panel in a Cytek Aurora full-spectrum flow cytometry platform. Data on samples collected pre-vaccine and 4-, 12-, 24-weeks post 2-doses and 4-, 12-weeks post-third dose will be presented. Result(s): 40/61 enrollees (age 38.3+/-10.9;77.5% female;57.5% non-white) had 24-week post-vaccination data and 9 patients had 4-week post 3rd dose data. Antibody response increased from prevaccine level of 972.0 U/mL to 6307.4 U/mL at week-4 (p=0.0002), then decreased to 4633.8 u/mL at week-12 (26% decrease from week-4, p=0.1377), and further to 2878.4 u/mL at week-24 (37% decrease from week-12, p value=0.109). Spikespecific IFNgamma T-cell responses by ELIspot were 125.7 SFU/106 cells pre-vaccine, increased to 362.9 SFU/106 cells at week-4 (p=0.009), then to 511.5 SFU/106 cells at week-12 (40.9% increase relative to 4-week time-point, p=0.8474), and remained elevated at 501.7 SFU/106 cells at week-24 (p=0.7393, 1.9% compared to week 12). 4-week post 3rd dose, Ab level increased to 5094.8 U/mL (189.9% compared to pre-3rd dose, p =0.076) and IFNgamma responses to 1253.3 SFU/106 cells (484.5% increase, p=0.037). Conclusion(s): Antibody responses to 2-series vaccine peaked at 4 weeks and trended downward thereafter, while cellular responses were sustained at 24 weeks. Third-dose resulted in marked increases in both antibody and T-cell responses 4-weeks. Expanded analyses, including in-depth immunophenotyping and 12-week post 3rd vaccination responses will be presented.

10.
Surface Engineering and Applied Electrochemistry ; 58(5):523-539, 2022.
Artigo em Inglês | EuropePMC | ID: covidwho-2092254

RESUMO

Modern civilization, providing economic and social progress, at the same time objectively creates—sometimes close to ideal—conditions for the spread of various infections. The catastrophic consequences of the SARS-CoV-2 pandemic clearly indicate that homo sapiens appeared to be unable to effectively resist the onslaught of the coronavirus. The purpose of this publication is an attempt to fill the gap in the development of effective methods and means for microbiological decontamination that are optimal in terms of critical parameters. The observational data indicate that a significant number of SARS-CoV-2 coronavirus infections occur by air without a direct contact with the source, including over a long time interval. Precipitation helps to cleanse the air from pollutants and viruses, reducing noncontact contamination, which additionally brings up to date the problem of optimal microbiological decontamination of the air environment and surfaces. A thermodynamic approach has been used to optimize microbiological sterilization. It is shown that irreversible chemical oxidation reactions are the shortest way to achieve sterility, and they are capable of providing high reliability of decontamination. It has been established that oxygen is an optimal oxidant, including from the point of view of ecology, since its reactive forms harmoniously fit into natural exchange cycles. The optimal method for obtaining reactive oxygen species for disinfection is the use of low-temperature (“cold”) plasma, which provides the energy-efficient generation of oxidative reactive forms: atomic oxygen (O), ozone (O3), hydroxyl radical (•OH), hydrogen peroxide (H2O2), superoxide (

11.
Pediatriya - Zhurnal im G.N ; Speranskogo. 101(5):50-62, 2022.
Artigo em Russo | EMBASE | ID: covidwho-2081376

RESUMO

The pathogenetic basis for Pediatric Multisystem Inflammatory Syndrome (PMIS) associated with SARS-CoV-2 is systemic vasculitis resulting from hyperproduction of pro-inflammatory cytokines associated with dysregulation of the immune response. Clinical manifestations of PMIS include fever with features of Kawasaki Syndrome (KS) and multi-organ dysfunction coupled with frequent unusual heart involvement, ranging from mild with minimal ECG changes or elevated troponin to fulminant myocarditis or Takotsubo syndrome (TTS). The purpose of the research was to study the characteristics of cardiovascular disorders in Kawasaki-like multisystem inflammatory syndrome associated with COVID-19 in children observed in the East Siberian area of Russia. A single-center retrospective cohort study was carried out on the basis of the Irkutsk Oblast Regional Children's Clinical Hospital (Irkutsk, Russia): 36 patients with PMIS associated with COVID-19 in Nov. 18, 2020 - Dec. 31, 2021, including 21 boys (M/F ratio 1.4:1) at the average age of 7.5 years old (1.5 months to 17 years old). The diagnostic signs of KS were observed in 34 (94%) children, including the complete set of diagnostic signs in 21 (58%). Refractory fever and a sharp increase in inflammatory biomarkers were detected in all 36 (100%) children;multiorgan dysfunction in 31 (86%);thrombocytopenia in 24 (67%);gastrointestinal syndrome in 25 (69%);cerebral dysfunction in 24 (66)%;various cardiovascular disorders in 30 (83%), including: dilatation of the left ventricle (LV) and a decrease in myocardial contractility in 3 (8%);moderate coronary dilatation in 5 (14%);thickening of the posterior LV walls in diastole in 5 (13%);thickening of the interventricular septum in diastole in 6 (16%). According to the MRI results performed in 15 children the signs of myocardial damage were found in 6 (40%). LV dilatation and decreased myocardial contractility were noted in 3 (8%) children, clinically apparent thrombotic complications in 3 (8%) children as well, and severe neurological deficit in one patient (3%). An increase in the level of D-dimer was observed in 26 (72%) patients, thrombocytopenia in 24 (67%), a statistically significant correlation between thrombocytopenia and myocardial damage was found (R=-0.506, p=0.001). The treatment measures were given as follows: inotropic support (dobutrex/dobutamine) was received by 8 (22%), artificial lung ventilation - by 8 (22%), intravenous human immunoglobulin 1.5-2.0 g/kg/course - by 28 (77%), dexamethasone - by 24 (67%), tocilizumab - by 2 (5%) patients. All 36 (100%) patients have survived. Conclusion(s): the Kawasaki-like multisystem inflammatory syndrome associated with COVID-19 was accompanied by the cardiovascular disorders (pericarditis, arrhythmias, abnormal ECG changes, elevated troponin and/or natriuretic peptide, LV thickening on echocardiography, coronary dilatation) in most patients, although LV dilatation and decreased myocardial contractility were observed in a few cases only. A negative correlation between thrombocytopenia and myocardial damage was found, which may indicate the involvement of thrombotic microvascular inflammation in the genesis of myocardial disorders. Copyright © 2022, Pediatria Ltd. All rights reserved.

12.
Russian Journal of Cardiology ; 27(9) (no pagination), 2022.
Artigo em Russo | EMBASE | ID: covidwho-2081126

RESUMO

The possibility of heart inflammation (both myocardial and endocardial) months after a coronavirus disease 2019 (COVID-19) has not been practically studied, especially since approaches to the treatment of myocarditis in combination with various endocarditis forms have not been developed. Aim. To study the prevalence and mechanisms of SARS-CoV-2-associated endocardial injury in patients with morphologically verified post-COVID-19 myocarditis, as well as to develop approaches to comprehensive therapy. Material and methods. The study included 18 patients with severe morphologically verified post-COVID-19 myocarditis (men, 9;51,1+/-9,4 years;35 to 66 years). Patients with prior verified myocarditis/myocardial infarction, rheumatic heart disease, and systemic immune diseases were excluded. The average time after COVID-19 was 6,5 [3.5;10] months The diagnosis of myocarditis was confirmed by endomyocardial biopsy (including immunohistochemical examination with antibodies to CD3, CD20, CD45, CD68, and to SARS-CoV-2 antigens;polymerase chain reaction for SARS-CoV-2 RNA, DNA of cardiotropic viruses). The blood level of anticardiac antibodies was determined by indirect immunofluorescence. In addition, echocardiography, magnetic resonance imaging (n=8), cardiac multislice tomography (n=1), and coronary angiography (n=14) were performed. Results. Biopsy revealed active (n=12) and borderline (n=3) lymphocytic myocarditis, eosinophilic (n=2) and giant cell (n=1) myocarditis. In 4 patients, nonbacterial thrombotic endocarditis (NBTE) with parietal and intravascular thrombosis was diagnosed, and in one patient - infective endocarditis (IE) of the bicuspid aortic valve. Myocardial persistence of SARS-CoV-2 was detected in 72% of cases (in 3 patients - with NBTE;in 1 - with IE;in 9 - without endocarditis). Titers of anticardiac antibodies increased by 3-4 times in 94% of patients. Patients with endocarditis were characterized by larger heart chambers, lower ejection fraction (27,5+/-6,6 vs 36,0+/-13,4%), more severe pulmonary hypertension, and valvular regurgitation. Intraventricular thrombosis according to echocardiography/magnetic resonance imaging and cardiac embolism was not observed. Treatment in all patients included methylprednisolone at an average dose of 24 mg a day. In 10 patients, the result was monitored for at least 3 months as follows: the ejection fraction was 46,0+/-12,7% and 44,3+/-7,3% in patients with and without endocarditis, respectively. Conclusion. Endocarditis in patients with post-COVID-19 myocarditis was detected in 28% (1 patient - IE;4 - NBTE). The key mechanisms of post-COVID-19 myocarditis and NBTE are long-term (up to 18 months) myocardial persistence of SARS-Cov-2 and the development of an autoimmune reaction. Endocarditis was diagnosed in more severe patients, including those with giant cell and eosinophilic myocarditis. The effectiveness of steroid therapy in combination with anticoagu-lants in patients with NBTE requires further study. In case of IE, steroids can also be used in the treatment of myocarditis (in combination with antibiotics and im-munoglobulin). Copyright © 2022, Silicea-Poligraf. All rights reserved.

13.
Natsional'nyi Hirnychyi Universytet. Naukovyi Visnyk ; - (4):91-95, 2022.
Artigo em Inglês | ProQuest Central | ID: covidwho-2026599

RESUMO

Мета. Дати рекомендацп по вдосконаленню нормативно-правових актш щодо регулювання вщповщних правовщносин у сферi кримшалтци дшнь, пов'язаних İ3 порушенням законодавства про охорону пращ. Методика. Дослщження проблемних питань притягнення до вщповщальноста за порушення вимог законодавства про охорону пращ здшснювалося через вивчення та аналш: законодавчо! бази Украши;робта науковщв у вщповщних галузях;аналшу судово! практики (на прикладi аналiзу судово! практики за справами, розглянутими судами загально! юрисдикци Днiпропетровськоī областi та Верховним Судом за останш 3 роки) з питань притягнення осШ до кримшально! вiдповiдальностi за ч.ч. 1, 2 ст. 271 Кримшального кодексу Укра!ни «Порушення шення вимог законодавства про охорону пращ». Результата. Виявлеш окремi проблеми, що виникають при формуваннi кримiнально-правовоī практики притягнення до вщповщальноста осiб, обвинувачених у скоeннi кримiнальних правопорушень, пов'язаних и порушенням законодавства про працю, що призвело до спричинення шкоди здоров'ю працiвника або його загибелi, у тому чи

14.
Kardiologiia ; 62(8): 27-32, 2022 Aug 30.
Artigo em Russo, Inglês | MEDLINE | ID: covidwho-2025893

RESUMO

Aim      To study the effectiveness of nebulized surfactant therapy as a part of a multimodality treatment of severe and extremely severe COVID-19 viral pneumonia with concomitant cardiovascular diseases (CVDs).Material and methods  This retrospective controlled study analyzed a multimodality treatment of 38 patients with severe and extremely severe COVID-19 viral pneumonia and concomitant CVDs who were administered nebulized surfactant for correction of acute respiratory distress syndrome (ARDS). The control group consisted of 105 patients with severe and extremely severe novel coronavirus infection with concomitant CVDs who were not administered surfactant as a part of the multimodality therapy.Results Administration of nebulized surfactant as a part of the multimodality treatment in patients with COVID-19 allowed alleviating the severity of respiratory insufficiency (р<0.001), which decreased the death rate of patients with severe and extremely severe COVID-19 and undoubtedly demonstrated the effectiveness of this medicine. The timely multimodality therapy, including nebulized surfactant, improves the course of the disease. Thus, the absence of a possibility for administering nebulized surfactant for more than 4 days was associated with fatal outcomes (р=0.045).Conclusion      Administration of nebulized surfactant as a part of the multimodality treatment of severe and extremely severe COVID-19 and concomitant CVDs increases the survival (р<0.001) and reduces the mortality by 46 %. The risk factors of an unfavorable outcome of this disease include an age older than 65 (р=0.020), a positive polymerase chain reaction test (р=0.037), a ferritin concentration at baseline >600 mg /ml (р<0.001), and a surfactant treatment duration < 4 days (р=0.045). Further study of the efficacy of nebulized surfactants as a part of the multimodality therapy is required and should include randomized clinical trials with a large number of patients and the development of distinct criteria for the treatment of ARDS.


Assuntos
COVID-19 , Síndrome do Desconforto Respiratório , COVID-19/complicações , Humanos , Síndrome do Desconforto Respiratório/complicações , Síndrome do Desconforto Respiratório/tratamento farmacológico , Estudos Retrospectivos , SARS-CoV-2 , Tensoativos
15.
Innovation in Aging ; 5:599-599, 2021.
Artigo em Inglês | Web of Science | ID: covidwho-2012542
16.
Journal of Clinical Oncology ; 40(16), 2022.
Artigo em Inglês | EMBASE | ID: covidwho-2009520

RESUMO

Background: Standard of care for HER2+ early/first-line metastatic BC (EBC/MBC) is P + H and concurrent chemotherapy (CT);PH FDC SC offers faster, more convenient admin vs intravenous (IV) P + H. COVID-19 has caused unprecedented strain on healthcare systems and disruption to cancer care;treatment (Tx) at home may: enable pts to continue cancer Tx;reduce exposure to COVID-19;free up hospital resources. This study's main objectives: to enable continuity of care during COVID-19;to assess safety of PH FDC SC given at home. Methods: This is an ongoing single-arm, hybrid, decentralized clinical trial (NCT04395508). Pts with HER2+ EBC/MBC who completed concurrent CT with P + H IV and are receiving/about to receive maintenance P + H IV, PH FDC SC, or H SC are switched to PH FDC SC given at home by a home health nursing provider (HHNP) until disease progression, unacceptable toxicity, pt withdrawal, or physician recommendation (pts with EBC will complete ≤18 cycles). The study endpoint is safety. A subset of pts took part in HARRIET, a substudy of at-home cardiac surveillance with artificial intelligence-guided cardiac ultrasound and optional 6L ECG acquired by an HHNP. Results: Data for 114 pts (1 male) were available at cutoff (Jan 19, 2022): 18 (16%) completed Tx;20 (18%) discontinued;76 (67%) remain on study;79 (69%) had a COVID-19 vaccine while on study. Median age was 49 years;pts were balanced between EBC (n = 55, 48%) and MBC (n = 59, 52%);received a median of 6 (EBC) and 8 (MBC) cycles;and were from metropolitan (n = 109), urban (n = 4), and rural (n = 1) areas. 11 pts tested COVID-19-positive during the Tx phase: 8 continued Tx after appropriate COVID-19 Tx and/or quarantine. Safety is summarized in the table. No new adverse events (AEs) emerged due to home admin. AEs of special interest were grade (gr) 1-2: admin-related reactions (n = 76, 67%), hypersensitivity (n = 5, 4%), cardiac dysfunction (n = 4, 4%), except 1 case of gr ≥3 diarrhea. AEs leading to study Tx discontinuation or interruption/dose reduction occurred in 3 (3%) and 15 (13%) pts. A subset of 7 pts completed at-home cardiac surveillance testing;quantitative assessment of left ventricular ejection fraction was feasible in 3 (43%);5 (71%) preferred at-home surveillance to clinic. Conclusions: In this preliminary analysis, safety of PH FDC SC at home was consistent with the established P + H safety profile, indicating that PH FDC SC at home is a viable option for continuing BC care during and beyond COVID-19.

17.
Bull Exp Biol Med ; 173(4): 523-528, 2022 Aug.
Artigo em Inglês | MEDLINE | ID: covidwho-2007182

RESUMO

The study included umbilical cord blood samples (n=64) intended for cryogenic storage of hematopoietic stem cells and obtained from patients with a history of mild and moderate forms of COVID-19 during pregnancy. The control group was composed of samples (n=746) obtained from healthy women in labor. A comparative analysis of the volume of cord blood collected, the total leukocyte count, the relative and absolute content of cells with the CD34+/CD45+ phenotype revealed no significant differences between the groups.


Assuntos
COVID-19 , Sangue Fetal , Antígenos CD34 , Feminino , Sangue Fetal/química , Células-Tronco Hematopoéticas , Humanos , Gravidez
18.
Journal of the American College of Cardiology ; 79(9):2004, 2022.
Artigo em Inglês | EMBASE | ID: covidwho-2004636

RESUMO

Background: Cardiotoxicity is frequently monitored when anti-HER2 treatment (Tx) is used and is a potential reason for discontinuation. As patients (pts) live longer, improved surveillance via low-interventional management is critical. Advances in digital tools and the impact of COVID-19 are accelerating opportunities for in-home care. We initiated cardiac monitoring at home in a subset of patients from study NCT04395508, which provides continuity of care during the pandemic and home administration of pertuzumab, trastuzumab and hyaluronidase-zzxf (PH FDC SC) for pts with HER2-positive breast cancer. Methods: Pts must be on/will receive maintenance intravenous pertuzumab + trastuzumab/PH FDC SC/subcutaneous trastuzumab post-chemotherapy completion. Up to 36 pts will be enrolled at Memorial Sloan Kettering Cancer Center and selected Mayo Clinic sites. Pts will undergo remote cardiac surveillance by a Home Health Nursing Provider via Caption Artificial Intelligence (AI)-guided ECHO and ECG (KardiaMobile 6L) after a reference in-clinic ECHO and 12-lead ECG. Images and tracing will be assessed centrally. Key objectives are to evaluate feasibility of LVEF assessment at home based on AI-guided cardiac ultrasound images acquired by novice users without prior ECHO experience and to evaluate feasibility, including recording frequency and signal quality, of an AI-guided ECG algorithm at home by the pt with nurse oversight. Results: Enrollment began Aug 2021. Conclusion: For healthcare systems, HARRIET can improve Tx monitoring to avoid premature discontinuation;is a step toward moving away from specialized sites to flexible healthcare delivery and lower cost of care;and can remove logistical, financial and workload barriers of scheduling in-person ECHO readings. For pts, it can optimize care and increase confidence in anti-HER2 Tx and can provide access to specialty care in the comfort of their own home.

19.
Physica Medica ; 94:S24, 2022.
Artigo em Inglês | EMBASE | ID: covidwho-1996709

RESUMO

Background and Aims: Passive antibody administration through convalescent plasma has shown benefit in treating COVID-19 in the early stages of the disease in patients >65 years old, and in other viral outbreaks. A practical, rapid method to sterilize convalescent plasma while also maintaining antibody function would be valuable for safe treatment in future viral pandemics. Plasma sterilization by irradiation requires kGy of dose to deactivate bacteria and viruses of concern. Conventional lab-based irradiators would require days to reach such doses, while ultra-high dose rate irradiation (FLASH) would require minutes. We present a proof-of-concept on sterilizing plasma with 25 kGy in approximately 3 minutes without damaging the antibodies in the plasma. Methods: A Varian Trilogy LINAC was configured for 16 MeV FLASH electron irradiation. Frozen aliquots of convalescent plasma from patients with COVID-19 were placed in a 3D printed holder submerged in liquid aiming to preserve sample temperature (RT, 4°C or –20°C). The number of pulses was estimated with EBT-XD film. Samples were irradiated with a dose of 25 kGy in ~33,330 pulses over 185 seconds. Antibody binding against the receptor-binding domain (RBD) of the S1 region of SARS-CoV-2 was measured by ELISA pre- and post-irradiation. Results: Frozen plasma aliquots from 10 COVID-19 convalescent plasma donors were irradiated in frozen state to 25 kGy dose. IgG antibody binding against SARS-CoV-2 RBD after irradiation remained at 90.8% of non-irradiated samples (Fig. 1;OD 1.25 vs. 1.36, p<0.0003). (Figure Presented) Fig. 1 ( O034). Plasma aliquots from 10 convalescent plasma samples were irradiated at sterilizing 25-kGy doses. IgG binding to SARS-CoV-2 RBD antigen by ELISA is 90.8% compared to unirradiated. Conclusions: FLASH irradiation allows for rapid sterilization of blood plasma from potential pathogens while largely preserving antibody binding function and specificity.

20.
Aviakosmicheskaya i Ekologicheskaya Meditsina ; 55(4):23-35, 2021.
Artigo em Russo | Scopus | ID: covidwho-1994771

RESUMO

Drawing conclusions about the coronavirus infection risks and real-time decision-making is a primary duty of healthcare professionals. The agent-based modeling of events allows look closely at expectable hazards and paths of immediate infection as the grounds for planning personal tactics of infection prevention. The event modeling transforms verbal information (objects, relations, factors etc.) in constructs of knowledge for computer analysis of COVID-19 contagion. The knowledge constructs or information ontology may be helpful to health-care professionals in bringing to people of risky occupations true information of hazards and validity of the existing rules and regulations. © 2021 Slovo Ltd. All rights reserved.

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