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1.
2022 International Joint Conference on Neural Networks, IJCNN 2022 ; JOUR, 2022-July.
Artigo em Inglês | Scopus | ID: covidwho-2097620

RESUMO

COVID-19 has become a worldwide epidemic. Prediction of COVID-19 is an effective way to control its spread. Recently, some research efforts have made great progress on this task. However, these works rarely combine both the temporal and spatial domains for case number prediction. Moreover, most of them are only suitable for short-term prediction tasks, which cannot achieve good long-term predicting effects. Therefore, we use a method that combines human-mobility factors and time-series factors - the Spatio-temporal convolutional network (G-TCN) to deal with these problems. Firstly, we use data on the mobility of people between regions to generate graphs of regional relationships. Secondly, to process the spatial information at each moment, we apply multi-layer graph convolutional neural networks (GCNs) to aggregate multi-layer neighborhood information. And we input the information obtained by GCNs at different moments into temporal convolutional networks (TCNs), which are used to process the time-series information. Finally, we tested the proposed G-TCN method using datasets from four countries. The experimental results show that G-TCN has lower prediction errors than other comparison methods and can better fit the trend of COVID-19 development. © 2022 IEEE.

2.
Chinese Journal of Evidence-Based Medicine ; 20(3):365-368, 2020.
Artigo em Chinês | EMBASE | ID: covidwho-2067157

RESUMO

After the occurrence of public health emergencies, as the most direct front position, how to carry out medical treatment orderly, effectively, rapidly and safely in a short time has become the focus and difficulty of epidemic control. After the outbreak of 2019 novel coronavirus pneumonia (2019-nCoV), West China Hospital of Sichuan University, as a large-scale general hospital under the supervision of the CPC central committee, put people's life safety and health first, and attach great importance to the prevention and control of the epidemic. This paper introduces the ten measures taken by West China Hospital of Sichuan University to fight against the 2019-nCoV pneumonia, in order to provide reference for other hospitals. Copyright © 2020 West China University of Medical Science. All rights reserved.

3.
Chinese Journal of Evidence-Based Medicine ; 20(3):359-364, 2020.
Artigo em Chinês | EMBASE | ID: covidwho-2067155

RESUMO

Objectives To estimate the basic reproduction number of the novel coronavirus (2019-nCoV) and to provide support to epidemic preparedness and response. Methods Based on the susceptible-exposed-infected-removed (SEIR) compartment model and the assumption that the infection cases with symptoms occurred before January 26, 2020 were resulted from free propagation without intervention, we estimated the basic reproduction number of 2019-nCoV according to the reported confirmed cases and suspected cases, as well as theoretical estimated number of infected cases by other research teams, together with some epidemiological determinants learned from the severe acute respiratory syndrome. Results The basic reproduction number fall between 2.8 to 3.3 by using the real-time reports on the number of 2019-nCoV infected cases from People's Daily in China, and fall between 3.2 and 3.9 on the basis of the predicted number of infected cases from international colleagues. Conclusions The early transmission capability of 2019-nCoV is close to or slightly higher than SARS. It is a controllable disease with moderate-high transmissibility. Timely and effective control measures are capable to quickly reduce further transmission. Copyright © 2020 West China University of Medical Science. All rights reserved.

4.
Sustainability (Switzerland) ; 14(18), 2022.
Artigo em Inglês | Scopus | ID: covidwho-2066369

RESUMO

As a critical pattern to promote industrial growth and recover the economy, China has widely applied an electricity price-cutting policy, especially after the global spread of COVID-19. However, the current insufficient research indicates a noticeable knowledge gap around the actual outcome of this policy measure. This paper, therefore, aimed at filling this gap by focusing on the case of Zhejiang province. Recently, there have been three main kinds of price-cutting policies employed in Zhejiang, decreasing the general industrial electricity price, temporary electricity price-cutting, and targeted price reduction for large industries. Using a computable general equilibrium model that incorporates the Zhejiang electricity system’s operating characteristics, we simulated the economic impact of these electricity price adjustment policies. The results indicate that it was practical to promote the economy by reducing electricity prices, but the specific arrangements of policy have led to differences in economic stimulus consequences. This paper further obtained the multiplier effect in each industry. If electricity price adjustment policies were introduced only for industries with a higher comprehensive multiplier effect, the policy effectiveness would be further optimized. © 2022 by the authors.

5.
American Journal of Transplantation ; 22(Supplement 3):909-910, 2022.
Artigo em Inglês | EMBASE | ID: covidwho-2063523

RESUMO

Purpose: Kidney transplant recipients (KTRs) have poor outcomes compared to non-KTRs with acute COVID-19. To provide insight into management of immunosuppression (IS) during COVID-19, we studied immune signatures from the peripheral blood during and after COVID-19 infection from a multicenter KTR cohort. Method(s): Clinical data were collected by chart review. Paxgene blood RNA was polyA-selected and sequenced at enrollment Results: A total of 64 KTRs affected with COVID-19 were enrolled (31 Early cases (<4weeks from a positive SARS-CoV-2 PCR test) and 33 late cases). Out of the 64 patients, eight died and three encountered graft losses during follow-up. Among 31 early cases, we detected differentially expressed genes (nominal p-value < 0.01) in the blood transcriptome that were positively or negatively associated with the COVID-19 severity score (scale of 1 to 7 with increasing severity;Fig 1A). Enrichment analyses showed upregulation of neutrophil and innate immune pathways and downregulation of adaptive immune activation pathways with increasing severity score (Fig 1B). This observation was independent of lymphocyte count, despite reduction in immunosuppression (IS) in 75% of KTRs. Interestingly, compared with early cases, the blood transcriptome in late cases showed "normalization" of these enriched pathways after 4 weeks, suggesting return of adaptive immune system activation despite re-initiation of immunosuppression (Fig 1C). The latter analyses were adjusted for the severity score. Interestingly, similar pathway enrichment with worsening severity of COVID-19 was identifiable from a public dataset of non-KTRs (GSE152418), showing overlapped signatures for acute COVID-19 between KTRs and non-KTRs (overlap P<0.05) (Fig 1D). Conclusion(s): Blood transcriptome of COVID-KTRs shows marked decrease in adaptive immune system activation during acute COVID-19, even during IS reduction, which show recovery after acute illness. (Figure Presented).

6.
American Journal of Transplantation ; 22(Supplement 3):569, 2022.
Artigo em Inglês | EMBASE | ID: covidwho-2063390

RESUMO

Purpose: Kidney transplant recipients (KTRs) have poor outcomes vs non-KTRs with acute COVID-19. To provide insight into management of immunosuppression during acute COVID-19, we studied peripheral blood transcriptomes during and after COVID-19 from a multicenter KTR cohort. Method(s): Clinical data were collected by chart review. Paxgene blood RNA was polyA-selected and sequenced at enrollment. Result(s): A total of 64 KTRs with COVID-19 were enrolled (31 Early cases (<4weeks from a positive SARS-CoV-2 PCR test) and 33 late cases). Out of the 64 patients, eight died and three encountered graft losses during follow-up. Due to presence of mRNA reads in the blood transcriptome unmapped to the human genome, we aligned the mRNA short reads to the SARS-CoV-2 genome. Surprisingly, our strategy detected the SARS-Cov2 mRNA, especially Spike mRNA in 27 (87%) early cases, and 18 (54%) of late cases (Fig 1A and B). We then analyzed the raw reads from a public dataset of non-KTRs with Paxgene RNA (GSE172114). The SARS-CoV-2 Spike mRNA was detected in 2/47 (4.2%) critically ill COVID-19 cases and 0/25 noncritically ill cases in this non-KTR dataset (compared to KTRs, Chi-square P<0.001;Fig 1B). Among our KTRs, the amount of Spike mRNA was associated positively with the COVID-19 severity score (scale of 1 to 7 of increasing severity;Fig 1C) and inversely with time from initial positive PCR (Fig 1D). More interestingly, 7/64 patients had detectable Spike RNA-emia beyond 60 days after COVID-19 diagnosis. Of the 3 graft losses in our cohort, 2 occurred among these 7 patients. Conclusion(s): Blood transcriptome of KTRs with COVID-19 demonstrated a risk for persistent viremia with implications for pathogenesis of COVID-19 disease. This finding also supports using passive immune strategies in COVID-KTRs. (Figure Presented).

7.
European Neuropsychopharmacology ; 63:e175, 2022.
Artigo em Inglês | EMBASE | ID: covidwho-2061165

RESUMO

Background: Most neuropsychiatric disorders are moderately heritable but characterized by many genetic risk variants with weak effects. As such, it is difficult to point to direct causes or elucidate mechanisms of action. Despite the ease in gathering genetic data from humans, genetic data does not easily explain mechanistic effects. Gene expression on the other hand, which can more easily explain mechanistic effects, is harder to gather, especially in brain regions that are critical to the understanding of neuropsychiatric disease. To address this, we developed methods to impute genetically regulated gene expression (GReX) from genotypes and imputed GReX in over 440,000 European individuals in the Million Veteran Program (MVP) for a wide variety of tissues and cell types. Method(s): We use EpiXcan (based on PrediXcan) to develop machine learning models from training genotype, expression, and epigenetic data. We use custom scripts to impute individual GReX and perform a variety of downstream association analyses, including GReX Phenome Wide Association Studies (PheWAS) and Transcriptome Wide Association Studies (TWAS). Result(s): Results show an overlap in Schizophrenia genes identified by individual level TWAS and those identified by summary level TWAS informed by GWAS. TWASs for neuropsychiatric phenotypes identify genes established in the literature, but also novel targets. Inverse-variance meta-analyzed single gene imputation efforts across ancestries confirm clinical results obtained from COVID-19 positive individuals in both IL10RB and IFNAR2. GReX PheWAS for these particular genes using a novel negative binomial distribution for phecodes confirm COVID-19 related phenotypes. Finally, we describe various enriched pathways found in a COVID-19 TWAS, including immunological pathways. Discussion(s): GReX presents a unique solution to integrate effects across the genome and increase sample size in gene expression analyses. We are pursuing the creation of additional EpiXcan models, improved statistical methods for downstream association analyses, and replication efforts across biobanks. We plan to perform these analyses in all ancestries, available EpiXcan and PrediXcan models, and phenotypes. Disclosure: Nothing to disclose. Copyright © 2022

8.
International Conference on Green Building, Civil Engineering and Smart City, GBCESC 2022 ; 211 LNCE:465-473, 2023.
Artigo em Inglês | Scopus | ID: covidwho-2059767

RESUMO

The COVID-19 pandemic has seen the importance of confined space ventilation to reduce the risks of cross infection. To evaluate and compare the relative impacts of different mitigation strategies is important in order to reduce the risk of infection in a given situation. Using CFD methods, this study aimed to modulate the spread of exhaled contaminants in a floor-heated and ventilated space. Three different inlet velocities and four floor temperatures were used to assess the effect of the radiant floor combined with the displacement ventilation (RFDV) on room airflow and pollutant spread. Results show that RFDV reduced exposure to infection from 87% to 50% compared to the reference case. The inlet velocity is required to increase when the floor temperature is higher to decrease the contaminant exposure risk to in the room. This research provides a timely and necessary study of the ventilation and heating systems. These findings are expected to be useful for designing future of RFDV. © 2023, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

9.
Journal of Medical Pest Control ; 38(3):299-301, 2022.
Artigo em Chinês | Scopus | ID: covidwho-2056262

RESUMO

Objective To understand the contaminations of SARS-CoV-2 of imported frozen food and corresponding ke;environments in Nantong Farmers’ Wholesale Market. Methods The samples of imported frozen food, surface samples of key environmental objects and throat swabs, anal swabs and blood samples from employees were collected randomly, SARS-CoV-2 nucleic acid testing as well as specific serum antibody IgM and IgG testing were implemented. Results A total of 1 685 sample: of imported frozen food in Nantong, 2 432 samples from key environment, and 1 539 samples of anal swabs and throat swabs fron key practitioners were collected, all samples were confirmed to be negative for SARS-CoV-2 nucleic acid testing. A total of 299 blood samples were collected from key employees, and virus specific serum antibodies IgM and IgG were negative. Conclusion The imported frozen food and key environment sold in the Nantong have not been contaminated with SARS-CoV-2 temporarily, and it remains being necessary to further implements surveillance and control of Corona Virus Disease 2019(COVID-19). © 2022, Editorial Department of Medical Pest Control. All rights reserved.

10.
129th ASEE Annual Conference and Exposition: Excellence Through Diversity, ASEE 2022 ; 2022.
Artigo em Inglês | Scopus | ID: covidwho-2047137

RESUMO

This paper summarizes our experiences in running the REU site in a virtual environment at the University of Louisville. This is our first year to run the REU site. While our original plan when we proposed this project was to have a traditional in-person program, the ongoing COVID-19 pandemic and the concerns about safety for both faculty mentors and students involved made us decide to run it virtually. While we had to cancel some in-person activities such as face-to-face meetings, tours, and social events, we also added virtual events such as private and group MS Team meeting, Slack chat rooms (channels), and online movie nights and discussions. Nine out of the ten research projects were conducted entirely virtually. For one project that involves hardware component, we managed to mail a hardware kit to the student so that she could still work on her project remotely. Student evaluations indicate that this virtual REU site program, though in its first year, was quite successful and satisfactory. © American Society for Engineering Education, 2022.

11.
Fundamental Research ; 2(3):476-486, 2022.
Artigo em Inglês | Web of Science | ID: covidwho-2041756

RESUMO

Global pandemics such as COVID-19 have resulted in significant global social and economic disruption. Although polymerase chain reaction (PCR) is recommended as the standard test for identifying the SARS-CoV-2, conventional assays are time-consuming. In parallel, although artificial intelligence (AI) has been employed to contain the disease, the implementation of AI in PCR analytics, which may enhance the cognition of diagnostics, is quite rare. The information that the amplification curve reveals can reflect the dynamics of reactions. Here, we present a novel AI-aided on-chip approach by integrating deep learning with microfluidic paper-based analytical devices (mu PADs) to detect synthetic RNA templates of the SARS-CoV-2 ORFlab gene. The mu PADs feature a multilayer structure by which the devices are compatible with conventional PCR instruments. During analysis, real-time PCR data were synchronously fed to three unsupervised learning models with deep neural networks, including RNN, LSTM, and GRU. Of these, the GRU is found to be most effective and accurate. Based on the experimentally obtained datasets, qualitative forecasting can be made as early as 13 cycles, which significantly enhances the efficiency of the PCR tests by 67.5% (similar to 40 min). Also, an accurate prediction of the end-point value of PCR curves can be obtained by GRU around 20 cycles. To further improve PCR testing efficiency, we also propose AI-aided dynamic evaluation criteria for determining critical cycle numbers, which enables real-time quantitative analysis of PCR tests. The presented approach is the first to integrate AI for on-chip PCR data analysis. It is capable of forecasting the final output and the trend of qPCR in addition to the conventional end-point Cq calculation. It is also capable of fully exploring the dynamics and intrinsic features of each reaction. This work leverages methodologies from diverse disciplines to provide perspectives and insights beyond the scope of a single scientific field. It is universally applicable and can be extended to multiple areas of fundamental research.

12.
Frontiers in Environmental Science ; 10, 2022.
Artigo em Inglês | Web of Science | ID: covidwho-2022689

RESUMO

Between 2018 and 2022, a total of 231 PM2.5 samples were collected in Nantong, China, and analyzed online for 16 US EPA PAHs utilizing a variety of analytical methodologies, including high-performance liquid chromatography data analysis, principal component analysis, and characteristic ratio analysis. The seasonal variation and pollution characteristics of 16 PAHs in PM2.5 over a long period in Nantong, China, were analyzed, and correlations and traceability changes with a variety of emission sources were established. Additionally, health assessment models for BaP equivalent concentration, daily exposure dose, lifetime excess risk of cancer, and life expectancy loss were constructed for various ages and genders. The results indicated that the total number of days with BaP concentrations less than the national limit standard of 1.0 ng/m(3) was 60.17% (139/231), with rates of 25.40%, 35.71%, and 94.05% from 2019 to 2021, respectively;the total concentration range of 16 PAHs demonstrated a downward trend, but pollution was relatively severe in winter. The seasonal variation showed winter > autumn > spring > summer. The detection rates of 4 and 5 rings were generally high and fluctuated between dropping and increasing. Principal factor analysis and characteristic ratio traceability analysis indicated that PAH pollution is primarily caused by local coal-fired sources and traffic emissions, with a new trend of biomass combustion. Furthermore, BaP remains the primary contributor to carcinogenic factors, and the health risk is higher in females than in males, and in adults than in children. A low level of PAHs in the air may have health benefits. Traffic control and flow restrictions, as well as production restrictions, are all part of Nantong's COVID-19 pandemic prevention and control policies. These policies contributed to PAH risk prevention and control, as well as pollution reduction.

13.
7th International Conference on Distance Education and Learning, ICDEL 2022 ; : 127-132, 2022.
Artigo em Inglês | Scopus | ID: covidwho-2020434

RESUMO

The Covid-19 pandemic has altered the way people view online learning, which has experienced explosive growth since the pandemic and quickly cultivated the habit of online learning among the students. Online learning is not limited by time or space, and students can learn the courses repeatedly. Despite these advantages, it still has serious limitations in face of hardware-related courses like embedded technology, because it is not likely to provide opportunities for close-up observation of the real objects or any hands-on experience. Therefore, the learning effect will be greatly compromised. This paper proposed a solution for online learning of embedded technology course. It introduced the objective and content design of the course, the integration of ideological and political elements into the course, the teaching platforms that have been used as well as the concrete implementation process of online learning of the course, and it also statistically examined the effect of online learning. © 2022 ACM.

14.
Innovation in Aging ; 5:58-58, 2021.
Artigo em Inglês | Web of Science | ID: covidwho-2012709
15.
Journal of General Internal Medicine ; 37:S536, 2022.
Artigo em Inglês | EMBASE | ID: covidwho-1995721

RESUMO

CASE: The patient is a 66-year-old male presenting with progressive ambulatory dysfunction and lower extremity weakness that began ten days ago. Notably, the patient was admitted to the hospital two months prior with similar complaints. At that time, he was diagnosed with transverse myelitis after MRI showed a spinal cord lesion concerning for demyelination at T3-T4. The patient was treated with IV steroids and discharged. Neurology impression at time of discharge was transverse myelitis possibly related to Covid vaccination two weeks prior to admission. The patient states he was doing fine after initial discharge before recurrence of his progressive weakness and difficulty walking that led to the current admission. He denies fever, chest pain, abdominal pain, and bladder/ bowel incontinence. The patient is a former smoker and denies current alcohol or drug use. Past medical history includes WPW status post ablation, stable thoracic aortic aneurysm, peripheral neuropathy secondary to past alcohol abuse, osteoarthritis, GERD, and anxiety. Family history is remarkable for cancer, coronary artery disease, and diabetes in his father. Medications include metoprolol, tamsulosin, pantoprazole, olanzapine, and venlafaxine. Neurological exam is positive for atrophy and decreased vibratory sensation in bilateral lower extremities. His gait is not assessed due to safety concerns, but the patient notes he has begun using a cane to assist with ambulation. Otherwise, physical exam is unremarkable. Imaging studies include MRI showing T3-T4 hyperintensity, as seen during previous admission two months prior. Labs including ANA, rheumatoid factor, SPEP, CSF studies, and AQP-4 were negative. After an unrevealing workup, the patient experienced symptomatic improvement with IV steroids and was discharged home. IMPACT/DISCUSSION: Our case illustrates a clinical picture of Covid-19 vaccine-related transverse myelitis, a rare but serious complication of the vaccine. The prolonged course of this patient's complications is concerning, although the benefit of receiving the vaccine remains unquestionable. Furthermore, although the timing of symptom onset and vaccination suggests a relation, there are other diagnoses that could explain the presentation and further research is needed regarding vaccine-related side effects. This case emphasizes the importance of maintaining a high index of suspicion for neurological issues of unclear etiology following recent Covid-19 vaccination despite their rare occurrence. CONCLUSION: Teaching points: Diagnostic criteria for transverse myelitis includes sensory, motor, or autonomic dysfunction attributable to spinal cord, no evidence of cord compression, bilateral symptoms with clear sensory level, and inflammation defined by CSF analysis, elevated IgG, or MRI enhancement. Neurological complications of the Covid vaccine include general symptoms such as headache, fever, and fatigue, Bell's palsy, encephalomyelitis, myelitis, and cerebral venous sinus thrombosis.

16.
Advanced Functional Materials ; 2022.
Artigo em Inglês | Web of Science | ID: covidwho-1995522

RESUMO

With the rapid progress in nanomaterials and biochemistry, there has been an explosion of interest in biomolecule-modified quantum dots (QDs) for biomedical applications. Metal chalcogenide quantum dots (MCQDs), as the most widely studied QDs, have attracted tremendous attention in the biomedical field on account of their unique and excellent optical properties and the ease of biomolecular modifications. Herein, important advances in MCQDs over recent years are reviewed, from materials design to biomedical applications. Especially, this review focuses on the challenges encountered in the applications of MCQDs in biomedical fields and how these problems can be solved by rational design of synthesis methods and modifications, which have opened a universal route to develop the functionalized MCQDs. Moreover, recent processes in bioimaging, biosensing, and cancer therapy based on MCQDs are examined, including the rapid detection and diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This review provides broad insights into MCQDs in the biomedical field and will inspire material researchers to develop MCQDs in the future.

17.
Chinese Medical Ethics ; 35(5):583-588, 2022.
Artigo em Chinês | Scopus | ID: covidwho-1988521

RESUMO

This paper summarized three developing conditions and five service modes of mental health social work in Shanghai by reading literature and investigating and interviewing the social work service of mental health medical institutions in Shanghai. Three challenges to mental health social work after COVID-19 were identified:firstly, the reduction of direct services led to a decrease in the number of service beneficiaries, and the effectiveness of services could not be guaranteed;secondly, the application of social work methods was forced to adjust, which challenges the service ability of social workers;thirdly, the expansion or increase of the scope of service objects and the insufficient number of social workers led to difficulties in service response. In view of the above challenges and problems, countermeasures are proposed:ensure the continuity of professional relationship and service effectiveness through flexible and diversified service methods;knit for social work online working ability training, increasing network service experience;the scope of service objects expanding gradually and multi-sectoral cooperation to prevent psychological problems in key groups;set up a volunteer team to serve mental health. © 2022, Editorial department of Chinese Medical Ethics. All rights reserved.

19.
J Gerontol Nurs ; 48(8):52-56, 2022.
Artigo em Inglês | PubMed | ID: covidwho-1974982

RESUMO

The current article provides an overview of an interprofessional service-learning course that became virtual in the setting of the coronavirus disease 2019 pandemic. Telehealth video technologies were used to build an intergenerational, virtual classroom and increase engagement of older adults with interdisciplinary health professional students. The virtual classroom involved group health education sessions, individualized Medicare wellness visits, and a clinical huddle. The course addressed the public health need for reliable health information during the early days of the pandemic, social connection, and meeting the educational goals for health care students and older adults in a novel virtual setting. Lessons learned for the interdisciplinary team and for engaging older adults included the need for preparation reading, team building exercises, training videos, and telehealth competency checklists. Beyond the pandemic, adoption of virtual methods enables hybrid approaches to interprofessional education and builds competencies for delivery of telehealth and computer-based visits in professional practice settings. [Journal of Gerontological Nursing, 48(8), 52-56.].

20.
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue ; 34(6):561-570, 2022.
Artigo em Chinês | MEDLINE | ID: covidwho-1974966

RESUMO

The global coronavirus disease 2019 epidemic is still in a pandemic state. Aging population with underlying diseases is prone to become severe, and have a higher mortality. The treatment capacity of the critical care department directly determines the treatment success rate of critical illness. At present, there is still a certain gap between domestic and foreign countries in intensive care unit (ICU), which is not only in the allocation of medical staff, but also in the beds and settings. The current medical model cannot fully meet the needs of development. The experience and lessons of many major public health emergencies suggested that "dual track of peace and war" approach in discipline construction of critical care is the best medical model. Following the concept of "combination of peace and war", strengthening the discipline construction of critical care department in municipal and district designated hospitals, allocating reasonable standard ICU, step-down ICU and combat readiness ICU, establishing rapid response team, and strengthening regular training and scientific management may be the key measures to deal with the epidemic.

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