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1.
Tropical Journal of Natural Product Research ; 6(8):1233-1240, 2022.
Artigo em Inglês | EMBASE | ID: covidwho-2033551

RESUMO

The coronavirus disease 2019 (COVID-19) is caused by the recently discovered coronavirus and affects several countries worldwide. Some medications may alleviate or minimize some of the disease symptoms, but no drug have been proven to prevent or cure it. However, this study was aimed at investigating the role of some medicinal plants as potent inhibitors of COVID-19 main protease (MPro). More than 250 plant extracts with antiviral activity were exploited for their potential SARS-CoV2 medication using molecular docking. The conformational stability of the compounds extracted from the plants with MPro interactions was evaluated using molecular dynamics simulations. Then, the plant extracts with the highest binding energies were used for treatments by administering them to 50 COVID-19 patients, while the other 50 cases received only the drug without the plant extracts. The results of the theoretical analysis revealed high binding energies for seven compounds. Alliin stabilized COVID-19’s MPro while retaining critical connections and remained stable throughout the simulations. Marrubin and thymoquinone are also capable of protein stabilization over the simulated time. The test plants were observed to be effective against the virus in the COVID-19 patients, with a disease symptom improvement response rate of 78-86 and 60-72% for the first and second groups, respectively. Also, the percentage of oxygen increased from the second day after taking the extracts. Ground-glass opacity disappeared from the second group that received the plant extracts. The findings of this study suggest that these compounds have a great potential for therapeutic activity if isolated and administered alone.

2.
Current Journal of Neurology ; 21(2):83-90, 2022.
Artigo em Inglês | EMBASE | ID: covidwho-2033507

RESUMO

Background: Fatigue is one of the most frequent complaints in patients with motor neuron diseases (MNDs), with a significant impact on the quality of life (QOL). There is lack of enough evidence for current pharmacological or non-pharmacological treatments of fatigue in this population to be applied in clinical setting. Energy conservation strategies are one of the key interventions for fatigue management in chronic diseases. We aimed to investigate the effect of applying these techniques in the fatigue management of patients with MND. Methods: This randomized controlled trial (RCT) study was carried out on 28 patients with MND. Participants were randomly assigned to either the intervention or control group. In addition to routine treatment, patients in the intervention group participated in 3 weekly 1-hour energy conservation programs provided by an experienced occupational therapist. The Fatigue Severity Scale (FSS) score, 36-Item Short Form Survey (SF-36), and Canadian Occupational Performance Measure (COPM) were measured at baseline, immediately after the last intervention session, and one month later. Results: FSS and COPM significantly changed after the course in the intervention group (P < 0.001 and P = 0.001, respectively). Both FSS and COPM improved significantly toward the final assessment only in the intervention group. The SF-36 changes were not significant in each of the groups. Conclusion: According to the findings of the present study, using energy conservation strategies could lead to better mid-term fatigue management and occupational performance improvement, but it did not improve QOL in patients with MND.

3.
Acta Medica Iranica ; 60(6):384-386, 2022.
Artigo em Inglês | EMBASE | ID: covidwho-2033506

RESUMO

Safety monitoring of COVID-19 vaccination is paramount of importance. There are limited reports of Guillain-Barré syndrome (GBS) associated with the COVID-19 vaccination. The present study reported a case of GBS following the first dose of the Oxford-AstraZeneca SARS-CoV-2 vaccine. A 32-year-old man presented a history of progressive descending weakness and autonomic features within a month after receiving the Oxford-AstraZeneca SARS-CoV-2 vaccine. The neurological examination was consistent with acute polyneuropathy. The para-clinical investigations were in favor of acute demyelinating polyneuropathy. The patient was diagnosed with GBS, and IVIG was initiated as an acute treatment, which led to significant clinical recovery. We reported a case of GBS after receiving the Oxford-AstraZeneca vaccine. However, our findings dose not conclude a causal association between GBS and COVID-19 vaccination.

4.
Klinicheskaya Dermatologiya i Venerologiya ; 21(4):555-559, 2022.
Artigo em Russo | EMBASE | ID: covidwho-2033495

RESUMO

The pandemic of a new coronavirus infection has posed many challenges and questions for medicine. Dermatologists, in particular, have encountered a wide variety of cutaneous manifestations of this infection. Apart from a fairly broad coverage of various rashes and features of the course of many chronic dermatoses, only sporadic descriptions of inflammatory reactions to cosmetic fillers are available. Objec-tives. An extremely rare complication is described: an inflammatory reaction to the injection of a hyaluronic acid-based filler, which, in turn, led to the occurrence of xanthelasma at the sites of filler localization during the recovery period after COVID-19. Material and methods. A patient presented with yellow lesions in the nasolacrimal sulcus area following the resolution of an inflammatory response to the injection of a hyaluronic acid-based filler during the recovery period after a COVID-19 infection. Results. The diagnosis was confirmed by ultrasound of the face skin and soft tissues, and the optimal therapy regimen was determined. Conclusion. In the global medical practice, only single cases of xanthelasma and xanthelasma-like reactions after the filler injection are report-ed. In a scientific first, the pathogenetic chain including COVID-19, filler inflammatory response, and xanthelasma is described. The patho-genesis of this complication is also of particular interest and needs further study. Although extremely rare, physicians should be aware of this complication and its treatment options.

5.
NeuroQuantology ; 20(8):8399-8406, 2022.
Artigo em Inglês | EMBASE | ID: covidwho-2033473

RESUMO

Objectives: Dynamics of COVID-19 disease are changing with the emergence of the new variant of the COVID virus. Still, the severity of this disease is associated with comorbid conditions like diabetes mellitus (DM), hypertension, etc. and several biomarkers are studied. The objectives of the study were to estimate methemoglobin (Met-Hb), hemoglobin(Hb), lactate dehydrogenase (LDH) and C reactive protein(CRP) levels in COVID-19 patients with DM and without DM and then to compare between two groups. Materials and methods: This observational study was conducted in 40 COVID-19 patients with DM and 40 COVID-19 patients without DM from June 2021 to October 2021 in the biochemistry department of a tertiary care hospital. For all patients, estimation of Met-Hb, Hb, LDH and CRP levels were estimated on the 2nd-3rd day of hospital admission. Results: Met-Hb, LDH and CRP levels were significantly high and Hb levels were significantly low in elderly COVID-19 patients with DM than in those without DM (P<0.05). There was a significant positive correlation between Met-Hb with LDH and Met-Hb with CRP in both groups and a significant negative correlation was found between Met-Hb with Hb in the diabetic group. Conclusion: In elderly patients, diabetes is one of the important and independent risk factors for the severity of COVID-19 disease. Derangement of Met-Hb along with LDH and CRP shows the need for routine monitoring of Met-Hb. This may open new options in the treatment of COVID-19 disease with DM and improve outcomes in the future.

6.
World Journal of Clinical Cases ; 10(26):9462-9469, 2022.
Artigo em Inglês | EMBASE | ID: covidwho-2033423

RESUMO

BACKGROUND Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare and potentially life-threatening condition after receiving coronavirus disease vaccines. It is characterized by symptom onset at 5 to 30 d postvaccination, thrombocytopenia, thrombosis, high D-dimer level, and antiplatelet factor 4 (anti-PF4) antibody positivity. VITT can progress very fast, requiring urgent management. Only few studies have described its detailed clinical course and imaging changes. We report a typical VITT case in a patient who underwent regular repeated brain imaging examinations. CASE SUMMARY A young woman presented with headaches at 7 d after the ChAdOx1 nCoV-19 vaccine (AZD1222) injection. She then showed progressive symptoms of left upper limb clumsiness. Brain computed tomography revealed venous infarction at the right parietal lobe with a hyperacute thrombus in the cortical vein. Two hours later, brain magnetic resonance imaging revealed hemorrhage at the same area. Magnetic resonance venography showed an irregular contour of the right transverse sinus. Laboratory examination revealed a high D-dimer level, thrombocytopenia, and a high titer for anti-PF4 antibodies. She was treated with anticoagulants, intravenous immunoglobulin, and steroids and analgesic agents were administered for pain control. She had a marked improvement on headaches and clumsiness after treatment along with radiological thrombus resolution. During follow-up at the outpatient department, her modified Rankin scale at 90 d was 1. CONCLUSION Clinicians should be alerted whenever patients present with persistent and progressive headaches or focal motor/sensory deficits postvaccination

7.
World Journal of Clinical Cases ; 10(26):9428-9433, 2022.
Artigo em Inglês | EMBASE | ID: covidwho-2033422

RESUMO

BACKGROUND Students in the 9th grade of junior high school in Changsha were under a 75 d lockdown due to the coronavirus disease 2019 (COVID-19) pandemic. After the resumption of school post-lockdown, the 9th grade students in Changsha faced the entrance physical examination test for senior high school. CASE SUMMARY We report on 3 cases of occult fracture on the same site in adolescents of the same grade since resumption of school after the lockdown from the COVID-19 pandemic. Three students in the 9th grade of junior high school who were facing the physical examination in 2 wk were diagnosed with an occult fracture of the distal femur. CONCLUSION It is recommended that the students, parents, education providers and policy makers should all pay attention to the physical exercise of students when the resumption of school after lockdown occurs and they should be aware of occult fractures when the adolescents have pain after physical exercise.

8.
World Journal of Clinical Cases ; 10(26):9384-9389, 2022.
Artigo em Inglês | EMBASE | ID: covidwho-2033421

RESUMO

BACKGROUND Single-organ vasculitis (SOV) is characterized by inflammation of a blood vessel, affecting one organ, such as the skin, genitourinary system, or the aorta without systemic features. Gastrointestinal SOV is rare, with hepatic artery involvement reported only in two prior published cases. Herein, we presented a case of isolated hepatic artery vasculitis presenting after Pfizer-BioNTech mRNA corona virus disease 2019 (COVID-19) vaccination. CASE SUMMARY A 50-year-old woman with hypertension presented to our Emergency Department with recurrent diffuse abdominal pain that localized to the epigastrium and emesis without diarrhea that began eight days after the second dose of the Pfizer-BioNTech COVID-19 vaccine. Blood work revealed an elevated C-reactive protein (CRP) of 19 mg/L (normal < 4.8 mg/L), alkaline phosphatase 150 U/L (normal 25-105 U/L), gamma-glutamyl transferase (GGT) 45 U/L (normal < 43 U/L) and elevated immunoglobulins (Ig) G 18.4 g/L (normal 7-16 g/L) and IgA 4.4 g/L (normal 0.7-4 g/L). An abdominal computed tomography revealed findings in keeping with hepatic artery vasculitis. A detailed review of her history and examination did not reveal infectious or systemic autoimmune causes of her presentation. An extensive autoimmune panel was unremarkable. COVID-19 polymerase chain reaction nasopharyngeal swab, human immunodeficiency virus, viral hepatitis and Heliobacter pylori serology were negative. At six months, the patient’s symptoms, and blood work spontaneously normalized. CONCLUSION High clinical suspicion of SOV is required for diagnosis in patients with acute abdominal pain and dyspepsia.

9.
Journal of Clinical and Diagnostic Research ; 16(9):XD01-XD03, 2022.
Artigo em Inglês | EMBASE | ID: covidwho-2033408

RESUMO

Chronic lymphocytic leukaemia is a haematological malignancy that occurs due to an increased proliferation of mature B lymphocytes. It is considered to be the most common leukaemia in adults. Hyponatremia is commonly seen in such patients. This case report is about a 75-year-old male, who presented with giddiness, followed by altered sensorium. However, the patient had no motor weakness or sensory loss. Initially, a diagnosis of posterior circulation stroke was made but Magnetic Resonance Imaging (MRI) brain did not show associated signs. The routine investigations showed highly elevated total leukocyte count and hyponatremia. The patient was worked up for malignancy and diagnosed with Chronic lymphocytic leukaemia. Oncology reference was taken and treated with tablet Ibrutinib. On discharge, the patient's mentation improved, and he is on regular follow-up.

10.
Journal of Clinical and Diagnostic Research ; 16(9):XD01-XD04, 2022.
Artigo em Inglês | EMBASE | ID: covidwho-2033406

RESUMO

Pandemic was new experience for entire humanity. Medical fraternity was no exception. The cases of mucormycosis were on the rise during the second wave of the pandemic. Presented here are two cases which were combination of two diseases, one of which was squamous cell carcinoma of head and neck region and other one was sinonasal mucormycosis. Both patients were diabetics and had history of Coronavirus Disease-2019 (COVID-19) infection in past. Our literature search doesn't reveal any previously reported cases of this rare combination. There were certain challenges in management. Both diseases were lethal and treatment of one cannot be prioritised over other. Challenges in managing those cases were, reconstruction planning, perioperative management and postsurgery adjuvant therapy. In absence of previous experience to treat this combination or any literature available new treatment protocol were formulated. Cases were discussed in multidisciplinary team meetings and treatment plans were formulated. Mucormycosis and oral squamous cell carcinoma both were operated and reconstructed in same sitting. In one patient revision endoscopic debridement had to be done. Amphotericin B was started once diagnosis was confirmed. Patients were followed-up on weekly basis during first month and imaging was done every 15 days. Both patients had satisfactory recovery without any sign of progression of mucormycosis. Adjuvant radiation was given in both cases at appropriate time. At follow-up both patients were free from disease for six months. From these unique experiences it can be recommended that combination of sinonasal mucormycosis and squamous cell carcinoma of head and neck is very rare. Both diseases can be treated simultaneously. Excision and reconstruction can be done in single sitting. There is no need to delay or avoid adjuvant radiation. Multidisciplinary team approach is the key for treatment.

11.
Pharmacognosy Journal ; 14(4):450-454, 2022.
Artigo em Inglês | EMBASE | ID: covidwho-2033372

RESUMO

A 26-year-old man complained of shortness of breath for 3 days before the hospital admission. The patient had a history of coughing up blood and had consumed alcohol and drugs. Decreased vesicular auscultation and dull percussion in the left lateral pulmo. Laboratory result showed increased neutrophil-lymphocyte ratio C-reactive protein, D-dimer, procalcitonin, ferritin, and decreased albumin level. Pleural fluid analysis indicated the presence of exudate, SARS-CoV-2 PCR positive, and increased ADA level to 43 U/L. Based on the examination results, we suspected that the etiology of the massive pleural effusion was tuberculous pleurisy, particularly due to increased ADA levels. The patient was diagnosed with COVID-19 pneumonia with massive pleural effusion and tuberculous pleurisy. Massive pleural effusion in SARS-CoV-2 infection is rare. Thus, laboratory modalities for massive pleural effusion diagnosis are needed to determine the etiology and effective treatment for the patient. ADA analysis could be considered as an initial examination in patients with pleural effusion during the wait for pleural fluid culture results.

12.
Journal of Dermatology and Dermatologic Surgery ; 26(3):S23-S25, 2022.
Artigo em Inglês | EMBASE | ID: covidwho-2033232

RESUMO

Lethal midline granuloma is a rare aggressive, mutilating disorder of the upper airways. It is most likely secondary to natural killer/T-cell lymphoma and is difficult to diagnose owing to the varied and nonspecific symptoms. It is usually prevalent in the fourth decade of life and carries a poor prognosis. Our patient was a 19-year-old male with disease duration of 3 months, was diagnosed with lethal midline granuloma based on clinical examination, histopathology, and immunohistochemistry. The patient responded well to the first cycle of chemotherapy.

13.
Journal of Dermatology and Dermatologic Surgery ; 26(3):S8-S10, 2022.
Artigo em Inglês | EMBASE | ID: covidwho-2033231

RESUMO

People affected with severe acute respiratory syndrome coronavirus 2 can have a wide variety of symptoms. Literature and public discussion forums report persistent symptoms among COVID-19 survivors. More than 25% of COVID-19 survivors report hair loss as a persisting issue. The Centers for Disease Control and Prevention state that hair loss as a potential long-term effect of COVID-19 is currently under investigation. This report may be the first case of hair loss in the patient with postCOVID-19 infection in Saudi Arabia.

14.
Open Access Macedonian Journal of Medical Sciences ; 10(T7):176-179, 2022.
Artigo em Inglês | EMBASE | ID: covidwho-2033207

RESUMO

BACKGROUND: Pneumomediastinum is a rare disease associated with barotrauma and uncommonly occurs in viral pneumonia. Although the underlying mechanism of the incidence of pneumomediastinum in COVID-19 patients is not fully understood, barotrauma is the most probable cause. CASE REPORT: We reported a case of a 27-year-old woman with the chief complaint that was shortness of breath and diagnosed with COVID-19 based on reverse transcription polymerase chain reaction examination. On the 6th day after being admitted to the hospital, suddenly, the intensity of dyspnea was increased with the decrease of oxygen saturation. Computerized tomography of the chest confirmed pneumomediastinum and pneumonia COVID-19. There was no improvement of symptoms after oxygen and steroid administration. Emergency thoracotomy was not performed;yet, and the patient has died. CONCLUSIONS: Although pneumomediastinum is benign disease and self-limited disease, the presents of pneumomediastinum may relate to worse outcomes in COVID-19 infections.

15.
Open Access Macedonian Journal of Medical Sciences ; 10(T7):170-175, 2022.
Artigo em Inglês | EMBASE | ID: covidwho-2033206

RESUMO

BACKGROUND: The outbreak of coronavirus disease 2019 (COVID-19) has increased the burden of psychological stress. AIM: This study aims to determine the relationship between the length of isolation, the results of the COVID-19 polymerase chain reaction swab test, the time of reporting, and the level of knowledge with the degree of depression and anxiety in patients with swab results confirmed by SARS-CoV-2. METHODS: This study is an analytical observational study with a cross-sectional design. After the data were collected, a bivariate statistical analysis was carried out for the Kruskal–Wallis and Spearman Test. RESULTS: A total of 25 patients with a diagnosis of COVID-19 were included in this study. CONCLUSION: The study found that the length of isolation, frequency of swab, the time spent focusing on COVID-19, and level of knowledge were not related to the degree of depression and anxiety. However, mental attention and appropriate intervention are an important part of clinical care for those at risk.

16.
Open Access Macedonian Journal of Medical Sciences ; 9(T5):181-184, 2021.
Artigo em Inglês | EMBASE | ID: covidwho-2033200

RESUMO

BACKGROUND: The coronavirus or COVID-19 was originally discovered in the Chinese city of Wuhan in December 2019 which quickly spread to various countries and caused a global pandemic. According to the WHO, this coronavirus is called SARS-CoV-2 or severe acute respiratory syndrome coronavirus 2, it attacks the respiratory tract suddenly and can be fatal or cause the sufferer’s mortality in a short time. AIM: This study aims to find predictors of risk factors for the mortality of people infected with COVID-19;thus, it can help medical personnel make decisions quickly whether the patient has a good or bad prognosis. Faster and more precise decision-making can increase the efficiency of the needs of limited resources. METHODOLOGY: This research used a cross-sectional design of data collection of patients who died and returned home with a diagnosis of COVID-19 from medical records data of PKU Muhammadiyah Gamping Yogyakarta Educational Hospital. Logistic regression test was counted with a level of significance (p) < 0.05 using SPSS v.21 software RESULTS: Subjects who died were 63 people or 48.8%, while subjects who were alive were 66 people or 51.2%. Female subjects were 61 people or 47.3%, while male subjects were 68 people or 52.7%. The logistic regression analysis results showed that the variables determining the risk factors for death (p < 0.05) included age, impaired lung function, impaired kidney function, and increased D-dimer. CONCLUSION: Four risk factors for patients with COVID-19 determined whether the patient dies or lives, namely, age, lung disorders, impaired kidney function, and increased d-dimer.

17.
Frontiers in Immunology ; 13, 2022.
Artigo em Inglês | EMBASE | ID: covidwho-2032772

RESUMO

Hydroa vacciniforme-like lymphoproliferative disorder (HV-LPD) is a cutaneous form of chronic active Epstein-Barrvirus (EBV) infection, which can develop into the extremely rare systemic lymphoma. Patients with Inborn errors of immunity (IEI), such as common variable immunodeficiency (CVID), are at higher risk of developing a severe course of infections especially viral and malignancies than the general population. The aim of the study was to present complex diagnostic and therapeutic management of HV-LPD. The clinical diagnosis was confirmed at the histological and molecular level with next generation sequencing. HV-LPD was diagnosed in a patient with CVID and chronic active Epstein–Barr virus (CAEBV) infection. The patient was refractory to CHOP chemotherapy and immunosuppressive treatment in combination with antiviral drugs (prednisone, bortezomib, gancyclovir). The third-party donor EBV-specific cytotoxic T cells (EBV-CTL, tabelecleucel) were used, which stabilised the disease course. Finally, matched unrelated donor hematopoietic cell transplantation (MUD-HCT) was performed followed by another cycle of EBV-CTL.

18.
Future Virology ; 17(7):429-439, 2022.
Artigo em Inglês | EMBASE | ID: covidwho-2032730

RESUMO

Aim: This study aimed to evaluate chemokine receptor 5 delta 32 (CCR5-δ32) mutation and HIV-1 surveillance drug-resistance mutations (SDRMs) in peripheral blood mononuclear cells of long-term non progressors (LTNPs) of HIV-1-infected individuals. Materials & methods: This research was performed on 197 treatment-naive HIV-1-infected patients. After follow-up, it was determined that 15 (7.6%) of these people were LTNPs. The PCR assay was performed to identify the CCR5 genotype and HIV-1 SDRMs. Results: One (6.7%) of the LTNPs was heterozygous (wt/δ32) for the CCR5 delta 32 (CCR5δ32). However, none of the individuals was homozygous for this mutation (δ32/δ32). Moreover, none of the LTNPs showed HIV-1 SDRMs. The CRF35-AD subtype was the most dominant subtype, with a percentage of 93.3%. Conclusion: Iranian elite controllers are negative for CCR5-delta 32 homozygous genotype and drug resistance against antiretroviral drugs.

19.
BMJ Supportive and Palliative Care ; 11:A38-A39, 2021.
Artigo em Inglês | EMBASE | ID: covidwho-2032476

RESUMO

Background In response to the COVID-19 pandemic, the hospice moved to digital approaches. Whilst tele-rehabilitation has shown benefits for various chronic health conditions (Bhatt, Patel, Anderson, et al., 2019;Zanaboni, Hoaas, Lien, et al., 2017;Hwang, Bruning, Morris, et al., 2017), there is a gap in the literature on telehealth interventions for palliative rehabilitation. Aim To evaluate digital delivery of a palliative rehabilitation programme and obtain perceptions of users and staff. Methods All members of the Fatigue and Breathlessness (FAB) follow-on group (n=19) were invited to complete a questionnaire on the experience of transitioning to Zoom sessions. Descriptive statistics were produced using the statistical software package, Stata (Version 15;StataCorp, 2017). Qualitative data were analysed using an inductive thematic analysis framework (Braun & Clarke, 2006). Three members of the rehabilitation team were interviewed about encountered benefits and challenges. Results Thirteen members completed the questionnaire (68%) and all were positive about the transformed sessions. Eight respondents (62%) felt that the Zoom sessions were 'no different' or 'better' than in-person sessions. No adverse events were reported. Themes from open-ended comments included patient-level effects such as maintained exercise and social contact when in isolation and removed travel requirements. At the service level, there was improved access but technological challenges. Most respondents (9, 69%) suggested keeping the option of Zoom for flexibility and 46% (6) wanted both staff-led and self-led elements. The rehabilitation team felt their rapid response and team working enabled efficient transition to Zoom. This included risk assessments, particularly for those living alone. With help, users quickly learned and the virtual delivery provided opportunities to try new activities. At times, staff found the 'silent audience' challenging. The rehabilitation team felt the approach may only work with groups with existing rapport. Conclusions The hospice rehabilitation team now provide concurrent sessions at home via Zoom and in the hospice. These access options provide choice, appear to be acceptable and offer flexibility around changing condition status and personal factors.

20.
BMJ Supportive and Palliative Care ; 11:A37-A38, 2021.
Artigo em Inglês | EMBASE | ID: covidwho-2032473

RESUMO

Background In 2020 Highland Hospice faced the challenge of continuing the rehabilitation service delivered by our inpatient physiotherapist and occupational therapist. The service was originally delivered by admission to the unit for a five-day (Respiratory) or 10-day (Neurological) stay with intensive multi-disciplinary team rehabilitation. The team adapted the delivery of this service due to COVID-19 restrictions using the Zoom platform (licensed version). Aim To continue to provide ongoing rehabilitation for palliative care patients during COVID-19. Methods Referrals were received as usual from respiratory/ neuro nurses or consultant. Screening was carried out in a weekly meeting with the allied health professionals and doctors. Appropriate patients were contacted by telephone to schedule an initial assessment before setting up a Zoom call or home visit to set up technology. Patients were seen in person (if hearing or technology was an issue), or virtually for 6- 12 weeks. Results Of the eleven patients to date there were challenges for some but all participated and benefited. A survey was sent to participants. Three people responded. All three respondents said their goals were clear after the first session.•The respondents either mostly agreed/or agreed that their symptoms were better controlled.•Activity levels had increased.•Ability to cope was better.•Knowledge of helpful techniques was better and,•Quality of life was better after attending the service for the 6- 12 week period. Feedback from participants includes: 'The service was friendly and positive';'It helped me immensely';'a friend had been in respiratory crisis and I was able to help her while she waited for the ambulance - that felt good'. Conclusion Despite challenges, a virtual approach for palliative rehabilitation provided beneficial outcomes for patients who would not have been able to attend in person. This method will likely form a part of our services going forward.

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