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1.
NeuroQuantology ; 20(8):7940-7952, 2022.
Artigo em Inglês | EMBASE | ID: covidwho-2033464

RESUMO

Background: The COVID-19 had profound effects on nurses' general health. The severity and extent of the COVID-19 epidemic means it is highly likely that health personnel will suffer from psychological stress as a result the direct contact they have with patients who are infected. The goal of this research is to assess the level of anxiety and stress behaviors in B.Sc Nursing students, and to determine the relationship between stress levels and levels of coping, and socio-demographic variables. Methods: This study was cross sectional study. The sample size consisted of 500 BSc nursing students and samples were selected using convenient sampling techniques and the data was collected through self-administered COVID 19 stress scale and COVID 19 coping scale. Results: The study revealed that majority of students (22 %) were male and (78%) were female. Result showed that only (8%) has mild stress, (91%) had moderate stress and had (1%) severe stress, and (2.2%) had poor coping, (96.8%) had average coping and (1%) good coping. There was negative significant correlation (r=-0.721) between stress and coping behaviour among nursing year nursing students. There was significant association between level of stress and demographic variables such as age, education of father and mother, occupation of father and mother and family income. Conclusion: Nursing students' stress levels should be examined on a regular basis, contributing variables should be recognized, and the nurse administrators should establish a guidance, counselling, and stress management program to especially manage the stress during pandemic.

2.
Journal of the Canadian Association of Gastroenterology ; 4, 2021.
Artigo em Inglês | EMBASE | ID: covidwho-2032039

RESUMO

Background: The COVID-2019 pandemic continues to restrict access to endoscopy, resulting in delays or cancellation of non-urgent endoscopic procedures. A delay in the removal or exchange of plastic biliary stents may lead to stent occlusion with consensus recommendation of stent removal or exchange at three-month intervals [1-4]. We postulated that delayed plastic biliary stent removal (DPBSR) would increase complication rates. Aims: We aim to report our single-centre experience with complications arising from DPBSR. Methods: This was a retrospective, single-center, observational cohort study. All subjects who had ERCP-guided plastic biliary stent placement in Halifax, Nova Scotia between Dec 2019 and June 2020 were included in the study. DPBSR was defined as stent removal >=90 days from insertion. Four endpoints were assigned to patients: 1. Stent removed endoscopically, 2. Died with stent in-situ (measured from stent placement to documented date of death/last clinical encounter before death), 3. Pending removal (subjects clinically well, no liver enzyme elevation, not expired, endpoint 1 Nov 2020), and 4. Complication requiring urgent reintervention. Kaplan-Meier survival analysis was used to represent duration of stent patency (Fig.1). Results: 102 (47.2%) had plastic biliary stents placed between 2/12/2019 and 29/6/2020. 49 (48%) were female, and the median age was 68 (R 16-91). Median follow-up was 167.5 days, 60 (58.8%) subjects had stent removal, 12 (11.8%) died before replacement, 21 (20.6%) were awaiting stent removal with no complications (median 230d, R 30-332), 9 (8.8%) had complications requiring urgent ERCP. Based on death reports, no deaths were related to stent-related complications. 72(70.6%) of patients had stents in-situ for >= 90 days. In this population, median time to removal was 211.5d (R 91-441d). 3 (4.2%) subjects had stent-related complications requiring urgent ERCP, mean time to complication was 218.3d (R 94-441). Stent removal >=90 days was not associated with complications such as occlusion, cholangitis, and migration (p=1.0). Days of stent in-situ was not associated with occlusion, cholangitis, and migration (p=0.57). Sex (p=0.275), cholecystectomy (p=1.0), cholangiocarcinoma (p=1.0), cholangitis (p=0.68) or pancreatitis (p=1.0) six weeks prior to ERCP, benign vs. malignant etiology (p=1.0) were not significantly associated with stent-related complications. Conclusions: Plastic biliary stent longevity may have been previously underestimated. The findings of this study agree with CAG framework recommendations [5] that stent removal be prioritized as elective (P3). Limitations include small sample size that could affect Kaplan-Meier survival analysis. Despite prolonged indwelling stent time as a result of COVID-19, we did not observe an increased incidence of stent occlusion or other complications.

3.
Journal of Thoracic Oncology ; 17(9):S130-S131, 2022.
Artigo em Inglês | EMBASE | ID: covidwho-2031505

RESUMO

Introduction: There is a subset of NSCLC patients ineligible for benefit from TKIs/Immunotherapy (e.g. STK11 mutation conferring resistance to Immunotherapy). Besides, many patients cannot afford these therapies. Metformin has anticancer properties acting both on glycolytic metabolism and tumor microenvironment. In vitro studies suggest synergism between metformin and pemetrexed. STK11 deficient cell lines are more sensitive to metformin. Clinical studies combining metformin with chemotherapy are limited by small sample size. We conducted an exploratory phase-2 clinical trial of metformin with pemetrexed/carboplatin in advanced non-squamous NSCLC. Methods: This was a single center, open label, single arm phase 2 clinical trial with a Simon’s two stage design. The null hypothesis was that the combination would not improve the 6-month PFS rate by 15%, from 50%. Treatment-naive, non-diabetic patients aged 18-75 years with NSCLC (adenocarcinoma/not-otherwise-specified) with stage IV disease having ECOG PS 0-2 with unmutated EGFR/ALK and without brain metastasis or with asymptomatic brain metastases were treated with pemetrexed-carboplatin chemotherapy and metformin for six months. The primary outcome was 6-month progression free survival (PFS) rate. Secondary outcomes were safety, overall survival (OS), overall response rate (ORR), proportion of STK 11 mutation and effect of STK 11 mutation on 6-month PFS rate. PFS and OS were estimated using the Kaplan-Meier method. Targeted sequencing was attempted for available tissue specimens. Results: The first interim analysis was performed after enrollment of 26 patients for the first stage (before the target accrual of first stage was reached) due to slow accrual, in view of COVID pandemic. The study was terminated after first stage for futility. The median age of patients in the study was 52 years (range, 30 to 68) and 18 patients (69.0%) were males. Half of the patients had ECOG-PS 2. Brain metastases were present in eight (31%) patients and among these four (50%) were symptomatic at presentation. The median follow-up time was 25 months. The median PFS was four months. 6-month PFS rate was 28% (95% CI - 0.12 to 0.46). Of the 25 evaluable patients, five (20%) had a partial response, and eight (32%) had stable disease;13 (52%) of the patients had disease control. The median OS was 16 months. During combined therapy, 14 (54%) and 3 (11%) patients had any grade and grade 3 anemia respectively. One patient had grade 3 neutropenia. Among non-hematological toxicities, gastrointestinal toxicities (nausea, vomiting and diarrhea) were the most common. No grade 4 toxicities were reported. There were no treatment discontinuations, however treatment delay due to grade three toxicities was present in two patients. Dose modification for Metformin was required in four patients. Targeted Sequencing was possible in nine cases. Two of these patients had STK11 mutation and an associated bad outcome (PFS < 2 months). Conclusions: We could not demonstrate the benefit of combination of Metformin with pemetrexed-carboplatin in terms of improvement in 6-month PFS rate. The addition of metformin to pemetrexed-carboplatin has an acceptable safety profile. Future trials should test metformin in specific subsets (STK11 mutated) and in combination with immunotherapy and TKIs. Keywords: Metformin, NSCLC, STK11

4.
Journal of the American Academy of Dermatology ; 87(3):AB184, 2022.
Artigo em Inglês | EMBASE | ID: covidwho-2031396

RESUMO

Filaggrin plays a key role in the barrier function of the skin. Mutations in the gene encoding profilaggrin/filaggrin, FLG, are a predisposing factor for atopic dermatitis (AD). Thymus and activation-regulated chemokine/ C-C motif chemokine ligand 17 (TARC/CCL17) along with immunoglobulin (Ig) E, are considered reliable serum markers of Th2-dominant inflammation. We performed analyses of association between FLG mutation status and the serum levels of IgE, TARC, and history in patients with AD. This study was approved by the Ethics Review Committee of Nagoya University Graduate School of Medicine, Aichi, Japan. Twenty-eight patients (14 males, 14 females;age range 3–45 y) with AD, who visited the out-patient clinic of dermatology, Hirosaki University Hospital, were included. Of the 28 AD patients, 5 were carriers of 1 of 10 FLG mutations. Thus, the incidence rate was 17.9%. FLG mutations were associated with putative hay fever (odds ratio = 10 [95% CI 1.15–86.89]), however, were not associated with asthma (odds ratio = 5.5 [95% CI 0.28–107.16]). As for the aggravated COVID-19 patient, it was confirmed that a serum TARC level showed a low value. Although there is not the statistical significant difference between IgE, TARC, and FLG mutations, we found an association between FLG mutation positivity and putative hay fever in AD patients. Our study is limited by the small sample size, nevertheless, the findings show a significant association between FLG mutations and hay fever and provide evidence for the role of FLG mutations in the pathogenesis of hay fever.

5.
Computers, Materials, & Continua ; 73(3):4611-4626, 2022.
Artigo em Inglês | ProQuest Central | ID: covidwho-2026575

RESUMO

The design of a new adaptive version of the multiple dependent state (AMDS) sampling plan is presented based on the time truncated life test under the Weibull distribution. We achieved the proposed sampling plan by applying the concept of the double sampling plan and existing multiple dependent state sampling plans. A warning sign for acceptance number was proposed to increase the probability of current lot acceptance. The optimal plan parameters were determined simultaneously with nonlinear optimization problems under the producer’s risk and consumer’s risk. A simulation study was presented to support the proposed sampling plan. A comparison between the proposed and existing sampling plans, namely multiple dependent state (MDS) sampling plans and a modified multiple dependent state (MMDS) sampling plan, was considered under the average sampling number and operating characteristic curve values. In addition, the use of two real datasets demonstrated the practicality and usefulness of the proposed sampling plan. The results indicated that the proposed plan is more flexible and efficient in terms of the average sample number compared to the existing MDS and MMDS sampling plans.

6.
Vaccines ; 10(8):1298, 2022.
Artigo em Inglês | ProQuest Central | ID: covidwho-2024369

RESUMO

Background: This study explored awareness and adhesion of parents to the recommendations for influenza vaccination for their children. Methods: This cross-sectional study was conducted from March to June 2022 among parents of 6 months–6 years-old children in Southern Italy. Results: Only 22.1% of parents were aware that influenza vaccination was recommended for healthy children, and 31.8% reported at least one influenza vaccination in the four influenza seasons from 2018/2019 to 2021/2022. Adherence was higher among parents who had received influenza vaccination at least once, who knew the main childhood vaccinations, who knew that influenza can be prevented, that influenza vaccination is recommended for healthy children, who believe that it is useful, and who have been informed about it by physicians. Willingness to vaccinate their children in the upcoming season was 48.6% and was higher among parents who had vaccinated their children at least once, believed that influenza vaccination protects against severe complications, believed that it is useful, and that it is not better for children to acquire immunization through illness than through vaccination. Conclusions: These findings suggest that efforts should be devoted to educating parents on the risks associated with the disease and the benefits of the vaccine.

7.
Toxics ; 10(8):454, 2022.
Artigo em Inglês | ProQuest Central | ID: covidwho-2024232

RESUMO

Cocoa is one of the major cash crops in Nigeria and its production is directly related to the effective utilization of agrochemicals. This paper analysed the factors influencing cocoa farmers’ compliance with agrochemical safety regulations. The data were collected from 326 cocoa farmers from Ogun and Osun states, using multi-stage sampling procedures. The data were analysed with Principal Component Analysis (PCA) and an Endogenous Tobit Regression model. The results showed that majority of the farmers were primarily growing cocoa and average ownership of personal protective equipment (PPE) was less than two. Awareness of manufacturers’ instructions was high for insecticides and fungicides, while majority of the farmers were not eating or drinking while handling agrochemicals. Safety compliance indicators were significantly influenced (p < 0.10) by farmers’ ownership of PPE, education, age, awareness of manufacturers’ safety instructions and health status. It was concluded that utilization of PPE was very low among the farmers and efforts to facilitate safety training on the use of different agrochemicals will facilitate safety compliance through proper understanding of manufacturers’ instructions.

8.
International Journal of Environmental Research and Public Health ; 19(17):10859, 2022.
Artigo em Inglês | ProQuest Central | ID: covidwho-2023708

RESUMO

The knowledge of long-term informal care is particularly interesting for social and health measures related to ageing. This study aims to analyze how Portugal differs from Denmark regarding long-term informal care, specifically referring to personal care received by older people. A cross-sectional study was developed in Portugal and Denmark through the Survey of Health, Ageing and Retirement in Europe (SHARE) in 2015, with a total of 2891 participants. Descriptive statistics and logistic regressions were performed. The findings suggest a significant association for older people from Portugal who receive long-term informal care from non-household caregivers and household caregivers. Moreover, as they age and are from Portugal, their availability to receive long-term informal care from non-household caregivers increases. Furthermore, older people in Portugal are more likely to receive long-term informal care from a household caregiver. It is important to take a closer look at long-term informal care in both countries and think about healthy ageing policies in the current context of the ageing population. This study provides knowledge about disaggregated health data on ageing in the European region, helping to fill research gaps related to older people.

9.
Clinics and Practice ; 12(4):640, 2022.
Artigo em Inglês | ProQuest Central | ID: covidwho-2023228

RESUMO

Background: Tele-prehabilitation is a behaviour change intervention that facilities the modification of unhealthy lifestyle behaviours. Understanding patients’ experiences of tele-prehabilitation provides important insights into service improvement. In this study, we aimed to describe our patients’ perceptions of tele-prehabilitation and capture their capabilities, opportunities, and motivations to participate. This was a qualitative study to inform our service design and delivery. Methods: Following purposive sampling, 22 qualitative semistructured interviews were conducted with patients in the community that had completed tele-prehabilitation. Interviews were recorded and transcribed. Deductive content analysis was used to map the identified themes against theoretical determinants of health behaviour change. Results: We conducted 22 interviews. Our patients described their overall experience of tele-prehabilitation as positive and provided important insights that impacted their capabilities, opportunities, and motivations to engage with our service. Our team provided them the capabilities and self-efficacy to engage by personalising multimodal plans and setting goals. The remote delivery of our service was a recurring positive theme in providing flexibility and widening accessibility to participation. A missed opportunity was the potential for peer support through shared experiences with other patients. Patients showed greater motivation to participate for immediate perioperative benefit compared to long-term health gains. Conclusion: Patients’ experiences and perspectives of tele-prehabilitation can be enhanced by incorporating the findings from this qualitative study into service redesign and delivery. We recommend: (1) applying holistic principles in care and goal-setting, (2) delivering a combination of home-based and in-centre programmes, and (3) engaging with patients at the start of their cancer journey when they are most motivated. In turn, this can result in more effective uptake, improve adherence to interventions, and greater satisfaction.

10.
Children ; 9(8):1248, 2022.
Artigo em Inglês | ProQuest Central | ID: covidwho-2023224

RESUMO

An inadequate nutrient intake correlates with malnutrition, a problem affecting many adolescents worldwide. Nutrient intake is associated with quality of life (QoL). Our study analyzed the relationship between nutrient intake and adolescents’ QoL. We conducted a cross-sectional study. Through simple random sampling, 157 adolescent girls were selected. Nutrition status was assessed using anthropometric measurements. Nutrient intake was collected using the food frequency questionnaire (FFQ). WHOQOL BREF was used to explore adolescent girls’ quality of life. The median of nutrient intake: energy (908.25 kcal);protein (24.16 g);carbohydrate (128.89 g);fat (21.89 g);vitamin A (77.10 mg);vitamin E (1.40 mg);vitamin B1 (0.19 mg);vitamin B2 (0.29 mg);vitamin B6 (0.45 mg);folic acid (35.13 mg);vitamin C (12.60 mg);calcium (197.46 mg);magnesium (93.72 mg);iron (2.64 mg);and zinc (2.09 mg). The adolescents’ QoL scores were physical health 44 (25–81), psychological domain 56 (19–94), social relationships 56 (19–94), and environmental domain 56 (31–100). The strongest correlations were between (1) physical health with carbohydrates, vitamin C, and fat;(2) psychological domain with calcium;(3) social relationships with carbohydrates and vitamin C;and (4) environmental domain with BMI and zinc. There was a significant positive correlation between the intake of some nutrients and adolescents’ QoL, despite the observation of some significant negative correlations. The findings of this study indicate that more attention should be focused on adolescents’ nutrient intake in order to improve their QoL.

11.
PLoS One ; 17(8), 2022.
Artigo em Inglês | ProQuest Central | ID: covidwho-2021923

RESUMO

Background The routine vaccination card is an important health record for children, but recent findings suggest that vaccination card retention in Cameroon is low, varying from 29%-53%. The aim of this study was to assess factors associated with children’s routine vaccination card retention in Cameroon. Methods This cross-sectional survey was conducted in Yaoundé in November 2021, targeting children aged 0–59 months. Participants were selected using a 2-stage systematic cluster sampling in which households were selected by a restricted sampling technique. Data were collected by interviewing the children’s parents/guardians, and a vaccination card was said to be retained if it was presented to the interviewer by the interviewees. Data were analysed using multiple logistics regression with R version 4.1.0 (2021-05-18). Findings A total of 529 households were assessed with 361 children aged 0–59 months enrolled: 51% girls and 49% boys. Children aged 0–11 months represented 24.4% of all participants, and children aged 12–59 months were 74.6%. Vaccination card retention was 24% (87), and positive predictors of card retention included: girl child (adjusted Odds Ratio = 1.34, p-value = 0.0269), the respondent being one of the biological parents of the child: mother (adjusted Odds Ratio = 5.97, p-value = 0.0034) or father(adjusted Odds Ratio = 4.69, p-value = 0.0067), and living in a richer household (adjusted Odds Ratio = 1.56, p-value = 0.038). On the other hand, negative predictors of card retention were: child aged 12–23 months (adjusted Odds Ratio = 0.44, p-value = 0.0209) or aged 24-59months (adjusted Odds Ratio = 0.13, p-value = 0.0000), and having an employed mother (adjusted Odds Ratio = 0.34, p-value = 0.0066). Conclusion Vaccination card retention in children aged 0–59 months in Yaoundé is low when compared with findings reported by studies from other locations in Cameroon. Besides, the poor and older children have lower odds of keeping routine vaccination cards. There is a need to design interventions to improve vaccination card retention, which considers household wealth and the age of the child.

12.
PLoS One ; 17(8), 2022.
Artigo em Inglês | ProQuest Central | ID: covidwho-2021905

RESUMO

Background Diabetes Mellitus (DM), a chronic metabolic disorder that caused about 4.2 million deaths and at least 760 billion dollars’ expenditure in 2019, has been targeted for action by leaders of WHO member countries. In Ethiopia deaths, due to DM reached 34,262 in 2013. Studies show effective lifestyle interventions;particularly medical nutrition therapy reduces HbA1c by 0.5 to 2%. However, practicing recommended diet is reported to be difficult. Not only Knowledge and practice but also perception studies are therefore necessary to design future health programs. Objective To assess diabetic self-care, dietary practice and associated factors among diabetes patients. Method Institution-basedbased cross-sectional study design was employed from february15-May15, 2020 in Jimma university medical Centre (JUMC). Systematic sampling of every other patient (K = 2.7) was employed to interview 371 participants. A previously validated tool was used to collect data through a face-to-face interview. A path analysis was used to fit the structural model and tests the hypothesized Health Belief Model (HBM) relationships. Result Response rate was 95.4% (354). Around 52% of the participants were male and 76.8% follow diabetic education at least some times. 42.4% and 48% of respondents have good dietary and general self-care practices respectively. With unstandardized coefficient (standard error) self-efficacy0.10 (0.01) being the strongest cues to action0.10 (0.02), perceived threat0.02 (0.01), and perceived barrier-0.08(0.01) constructs of HBM have a significant effect on dietary practice. Knowledge, social support and diabetes distress exert a significant indirect effect on dietary practice through health belief constructs with unstandardized path coefficient (standard error) of 0.22(0.03), 0.02(0.01), and -0.03(0.004) respectively. Conclusion In this study, the proportion of good practice is found to be lower for both dietary as well as general self-care. HBM can best fit to explain variability in dietary self-care practice;therefore, future interventions should be designed to address the vast perception and psychosocial factors influencing dietary self-care practices.

13.
PLoS One ; 17(9), 2022.
Artigo em Inglês | ProQuest Central | ID: covidwho-2021763

RESUMO

Introduction Substance use amongst adolescents remains a global public health challenge. The potential negative health outcomes of substance use suggest the need to understand the pattern of use and the associated factors among adolescents. This study aimed to describe the prevalence of substance use, SUDs, and PD and the associated factors in adolescent learners at public schools in Gaborone, Botswana. Methods A cross-sectional study was conducted at 13 public secondary schools in Gaborone among 742 students. Assessment tools included the World Health Organization drug questionnaire, DSM-5 interview for SUD, and the General Health Questionnaire-12. Results The mean age (SD) of the participants was 15.26 (1.57) years, and there were more females (55.5%). Over two-fifths (44.6%) of learners reported psychoactive substance use in the past 12 months, and 31.5% meeting DSM 5 criteria for a SUD. Alcohol was the most used psychoactive substance (25.1%). Male gender (AOR = 1.94;95% CI: 1.26–2.995), having a friend (AOR = 4.27;95% CI: 2.68–6.78), or father (AOR = 1.87;95% CI: 1.14–3.04), who uses substance, and higher levels of PD (AOR = 1.09;95% CI: 1.03–1.17) remained significantly associated with SUD. Regular participation in religious activities negatively correlated with SUD (AOR = 0.61;95% CI: 0.38–0.96). Conclusion The high prevalence of substance use and SUDs among in-school adolescents is concerning. Substance use programs need to include family-focused and religious-based therapy and youth empowerment in developing positive peer relationships. Also, they should be integrated with mental health screening to assess comorbid PD.

14.
International Journal of Pure Medical Research ; 7(8):1-4, 2022.
Artigo em Inglês | CINAHL | ID: covidwho-2012060
15.
Stroke ; : 101161STROKEAHA122037378, 2022 Jun 30.
Artigo em Inglês | MEDLINE | ID: covidwho-2009245

RESUMO

As stroke continues to represent a major global health care problem, advancing our knowledge of new effective and safe stroke interventions represents a public health priority. The identification of these therapies requires the conduct of high-quality and well-powered randomized clinical trials. Despite its potential to inform clinical practice, traditional randomized clinical trial models have their drawbacks, including elevated costs, long completion times, failure to recruit the target sample sizes, lack of diversity, and complex operational procedures. Therefore, improving the participants' experience and trials' overall efficiency constitutes an important unmet need. Innovative models such as virtual and decentralized patient-centric trials have been proposed as a valuable strategy in this pursuit. In this narrative review, we discuss the limitations of traditional randomized clinical trial models and present the concept, advantages, and challenges of decentralized digitally enabled approaches to the conduct of stroke clinical trials.

16.
Southern African Journal of Anaesthesia and Analgesia ; 28(1):S7-S8, 2022.
Artigo em Inglês | EMBASE | ID: covidwho-2010612

RESUMO

Background: Recent renewed interest in regional anaesthesia during the COVID-19 pandemic has inspired the application of neuraxial anaesthesia for previously unconventional indications, such as awake abdominal surgeries. These patients needed little sedation, since studies demonstrate that neuraxial anaesthesia causes sedation as measured by Bispectral Index (BIS). In contrast, no studies have investigated the possible sedative effects of non-neuraxial regional anaesthesia. Aim: This pilot randomised controlled trial (RCT) was designed as a template for, and to test the feasibility of performing a definitive RCT to establish if non-neuraxial regional anaesthesia has any sedative effect. Methods: Forty patients presenting for forearm surgery were randomly allocated to two treatment arms (supraclavicular block and control). Their level of sedation was quantitatively monitored before surgery for 60 minutes. Specific feasibility outcomes were planned and data collected according to CONSORT 2010 recommendations. Results: Out of 48 patients screened, 41 (85.42%) were invited to participate, 40 (97.56%) consented and 100% completed the study. Four (10.00%) BIS electrodes needed replacement, inadequate contact was shown in three patients (7.50%), data collection and form completion were deemed “easy”, and block success rate was 100%. Differences in mean BIS between groups were < 5, and a difference of 10% between groups in the incidence of BIS < 80 (85% block group, 75% control group) was shown. Conclusion: We propose that progression to formal RCT is feasible with modifications. Decrease in BIS value from baseline should be measured per patient, and clinically significant decrease should be estimated (we suggest a decrease of 10 or more), exclusion of emergency patients (starved for longer, more anxious, may affect BIS), the sample size should be 500 patients and multi-site involvement implemented.

17.
NeuroQuantology ; 20(8):6385-6394, 2022.
Artigo em Inglês | EMBASE | ID: covidwho-2010518

RESUMO

The purpose of this study was to explore whether or not Covid 19 had any effect on the marketing of sports in Jordan. In the study, a descriptive analytic technique was employed, and it also included the use of a questionnaire that was prepared and handed out to a convenience sample of Amman-based sports professionals. The study's sample size was 111 total participants that participated in the survey. The study concluded that Covid 19 affects negatively sports marketing, in addition it also affects the sports marketing mix (product, price, promotion and distribution) separately, as well as, there are no differences in the impact of Covid-19 on sports marketing in Jordan due to (Gender, Age, experience). While there are differences in the impact Covid-19 on sports marketing in Jordan due to Education level. The study recommends that sport officials would recruit professional experts in sports marketing to mitigate the impact of Covid 19 on sport activities.

18.
Journal of Behavioral Addictions ; 11:249, 2022.
Artigo em Inglês | EMBASE | ID: covidwho-2009761

RESUMO

Background: The development of gambling addiction overgrows in line with technological advances and an increasingly widespread internet network so that online gambling reaches various islands in Indonesia. Internet use is increasing during the COVID-19 pandemic and has an impact on mental health, in which some people are gambling to relieve stress. The number of patients with Gambling Disorder (GD) has been increasing in clinical practice. Methods: We distributed The Indonesian version of the South Oaks Gambling Screen (SOGS) via google form nationwide through the internet and social media from April 18 to May 15, 2021, to subjects (n=5810, age 18 to 59 years) selected using non-probability sampling and incidental sampling. We were looking for the prevalence of GD in Indonesia and divided subjects into two characteristics GD and non-GD. Results: GD prevalence was determined using the Indonesian version of SOGS with a sample size of 5810 and obtained 57 subjects with GD with a cut-off point of 8. The prevalence of GD in Indonesia was 1 %. Most of the subjects were male (73.2%), aged 18-25 years (53.3%). The most frequent gambling was betting on sporting events (16%). The most widely used devices for gambling practice are smartphones (67,4%). Conclusions: Internet use is increasing during the COVID-19 pandemic and has an impact on mental health. Some people were gambling to relieve stress. The prevalence of GD in Indonesia was 1%.

19.
Journal of Clinical Oncology ; 40(16), 2022.
Artigo em Inglês | EMBASE | ID: covidwho-2009662

RESUMO

Background: The ECOG-ACRIN Tomosynthesis Mammographic Imaging Screening Trial (TMIST), which opened in 2017, is a randomized trial designed to assess whether Tomosynthesis Mammography (TM) should replace Digital Mammography (DM) for breast cancer screening. It is hypothesized that women assigned to TM for 3-5 screening rounds will have fewer advanced breast cancers than the women assigned to DM. Advanced cancers are those that have distant metastases or positive nodes, are invasive tumors greater than or equal to 2.0 cm in size, or are invasive tumors greater than 1.0 cm in size that are triple negative or HER 2+. The initially planned enrollment of 164,946 women was due to be completed by the end of 2020, with follow-up concluded by 2025. There were substantial challenges in meeting this timeline, including the organizational and funding structure of the NCI National Clinical Trials Network which is dependent upon sites using their existing staffing resources (not always readily available at the time of study activation). This led to longer than anticipated start of enrollment for most interested sites and lower than anticipated annual enrollment per participating site based ultimately on the staffing support that could be allocated to manage TMIST. In addition, research staffing shortages and periodic research operations closures due to COVID-19 have also impacted enrolling TMIST sites, though unevenly, since the start of the pandemic. Enrollment plateaued at approximately 2,100 subjects per month by the end of 2020. With that accrual rate expected, the trial design was modified to reduce the sample size so that the study could be completed by 2027. Methods: With the approval of the NCI CIRB, we changed how the primary endpoint measure for TMIST is assessed from the number of advanced cancers that occur by 4.5 years after randomization to the time from randomization to occurrence of advanced cancers. All advanced cancers occurring within 7 years of randomization are now included and all participants followed for at least three years. In addition, the power of the study of the study was modified from 0.9 to 0.85, while the originally assumed effect size at 4.5 years was retained These changes allowed a reduction of sample size to 128,905, with subject recruitment projected to end in 2024. As of February 14, 2022, there are 125 sites open, 114 in the U.S. and 11 in other countries, with an additional 31 sites planning to open. As of February 14, 2022, a total of 63,845 women have been enrolled in the trial worldwide at 115 sites, with 20% of US participants self-identifying as belonging to minority racial and ethnic groups and 70% consenting to optional blood and/or buccal cell collection.

20.
Journal of Clinical Oncology ; 40(16), 2022.
Artigo em Inglês | EMBASE | ID: covidwho-2009632

RESUMO

Background: Immunotherapy is becoming a common therapy in cancer patients. Cancer patients on systemic therapy are a vulnerable population, making them highly susceptible to illness from any infection. The purpose of this study was to collect and analyze data reported by patients regarding the side effects of COVID-19 vaccines (Pfizer-BioNTech and Moderna) in cancer patients with solid tumors receiving immunotherapy. Due to the lack of studies and inclusion of cancer patients in the clinical trials for the vaccine, it is pivotal to investigate of the effects of the SARS-2-CoV vaccine on patients receiving immunotherapy to begin to bridge the current gap in knowledge. Methods: We performed a twophased retrospective analysis of adult patients (age ≥18 years) who received either Moderna or Pfizer-BioNTech COVID-19 vaccinations and were currently on immunotherapy (December 15th, 2020, through July 31st, 2021). Phase 1 included a tertiary health system (n = 15,910) in Northeast Georgia. Phase 2 involved cross-tabulation with the VAERS CDC database to compare results at a national level (n = 374,667). The primary endpoints were severity of side effects, timing of side effects and the relationship between the vaccines. The method to evaluate outcome was the Pearson-Chi-Squared test. Results: Results showed that patients on immunotherapy were more likely to have at least one side effect in the tertiary health system (OR 6.727 [95% CI, 2.748 -16.465] compared to least two side effects in the national dataset (X2 = 7.032, p < 0.05). This difference was driven by the Moderna vaccine recipients, demonstrating a higher likelihood of experiencing two or more side effects (X2 = 6.159, p < 0.05). Those receiving the Pfizer-BioNTech vaccine did not demonstrate statistically significant side effects. The most common reaction noted was weakness in both datasets, which was more likely to occur after the Moderna vaccine. Gender analysis showed no difference in side effects in those receiving immunotherapy. In terms of timing of side effects, patients on immunotherapy (M = 10.66, SD = 25.1) had a delayed side effect onset of 10 days vs. four days. (M = 4.72, SD = 15.5, p < 0.05). Conclusions: Both local and national datasets demonstrate cancer patients receiving immunotherapy compared to those that were on immunotherapy, were more likely to experience mild vaccine side effects, specifically weakness being the most common. There was no statistically significant increase in more serious adverse reactions. Additionally, side effect onset was delayed in patients on immunotherapy. These findings provide a foundation for understanding mRNA vaccines in patients on immunotherapy, with future research needs involving larger sample sizes.

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