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Researching COVID to enhance recovery (RECOVER) autopsy study protocol: Rationale, objectives, and design (preprint)
medrxiv; 2023.
ما قبل الطباعة
ي الانجليزية
| medRxiv | ID: ppzbmed-10.1101.2023.04.27.23289234
ABSTRACT
Importance SARS-CoV-2 infection can result in ongoing, relapsing, or new symptoms or organ dysfunction after the acute phase of infection, termed Post-Acute Sequelae of SARS-CoV-2 (PASC), or long COVID. The characteristics, prevalence, trajectory and mechanisms of PASC are poorly understood. The objectives of the Researching COVID to Enhance Recovery (RECOVER) Tissue Pathology Study (RECOVER-Pathology) are to (1) characterize prevalence and types of organ injury/disease and pathology occurring with PASC; (2) characterize the association of pathologic findings with clinical and other characteristics; (3) define the pathophysiology and mechanisms of PASC, and possible mediation via viral persistence; and (4) establish a post-mortem tissue biobank and post-mortem brain imaging biorepository. Methods:
RECOVER-Pathology is a cross-sectional study of decedents dying at least 15 days following initial SARS-CoV-2 infection. Eligible decedents must meet WHO criteria for suspected, probable, or confirmed infection and must be aged 18 years or more at the time of death. Enrollment occurs at 7 sites in four U.S. states and Washington, DC. Comprehensive autopsies are conducted according to a standardized protocol within 24 hours of death; tissue samples are sent to the PASC Biorepository for later analyses. Data on clinical history are collected from the medical records and/or next of kin. The primary study outcomes include an array of pathologic features organized by organ system. Casual inference methods will be employed to investigate associations between risk factors and pathologic outcomes.Discussion:
RECOVER-Pathology is the largest autopsy study addressing PASC among US adults. Results of this study are intended to elucidate mechanisms of organ injury and disease and enhance our understanding of the pathophysiology of PASC.
النص الكامل:
متاح
مجموعة:
المطبوعات المسبقة
قاعدة البيانات:
medRxiv
الموضوع الرئيسي:
Neurocognitive Disorders
/
Death
/
COVID-19
/
Multiple Organ Failure
اللغة:
الانجليزية
السنة:
2023
نوع:
ما قبل الطباعة
المراجع ذات الصلة
MEDLINE
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