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Persistent T cell-mediated immune responses against Omicron variants after the third COVID-19 mRNA vaccine dose (preprint)
researchsquare; 2022.
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| PREPRINT-RESEARCHSQUARE | ID: ppzbmed-10.21203.rs.3.rs-2176472.v1
ABSTRACT
The prime-boost COVID-19 mRNA vaccination strategy has proven to be effective against severe COVID-19 disease and death. However, concerns have been raised due to decreasing neutralizing antibody levels after COVID-19 vaccination and due to the emergence of new immuno-evasive SARS-CoV-2 variants that may require additional booster vaccinations. Here we show that within the vaccinated health care workers (HCWs) the third mRNA vaccine dose recalls both humoral and T cell-mediated immune responses and induces high levels of neutralizing antibodies against Omicron BA.1 and BA.2 variants. Three weeks after the third vaccine dose, SARS-CoV-2 wild type spike protein-specific CD4+ and CD8+ T cells are observed in 82% and 71% of HCWs, respectively, and the T cells cross-recognize both Omicron BA.1 and BA.2 spike peptides. Although the levels of neutralizing antibodies against Omicron BA.1 and BA.2 decline 2.5 to 3.8-fold three months after the third dose, Th1-type memory CD4+ T cell responses are maintained for at least 7 months post the second dose and 3 months post the third vaccine dose suggesting durable immune protection.
النص الكامل:
متاح
مجموعة:
المطبوعات المسبقة
قاعدة البيانات:
PREPRINT-RESEARCHSQUARE
الموضوع الرئيسي:
Death
/
COVID-19
اللغة:
الانجليزية
السنة:
2022
نوع:
ما قبل الطباعة
المراجع ذات الصلة
MEDLINE
...
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