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Designing a conserved peptide-based subunit vaccine against SARS-CoV-2 using immunoinformatics approach.
Oladipo, Elijah Kolawole; Ajayi, Ayodeji Folorunsho; Onile, Olugbenga Samson; Ariyo, Olumuyiwa Elijah; Jimah, Esther Moradeyo; Ezediuno, Louis Odinakaose; Adebayo, Oluwadunsin Iyanuoluwa; Adebayo, Emmanuel Tayo; Odeyemi, Aduragbemi Noah; Oyeleke, Marvellous Oluwaseun; Oyewole, Moyosoluwa Precious; Oguntomi, Ayomide Samuel; Akindiya, Olawumi Elizabeth; Aremu, Victoria Oyetayo; Aboderin, Dorcas Olubunmi; Oloke, Julius Kola.
  • Oladipo EK; Department of Microbiology, Laboratory of Molecular Biology, Immunology and Bioinformatics, Adeleke University, Ede, Osun State Nigeria.
  • Ajayi AF; Genomics Unit, Helix Biogen Consult, Ogbomoso, Oyo State Nigeria.
  • Onile OS; Reproduction and Bioinformatics Unit, Department of Medical Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State Nigeria.
  • Ariyo OE; Biotechnology Programme, Department of Biological Sciences, Elizade University, Ilara-Mokin, Nigeria.
  • Jimah EM; Department of Medicine, Infectious Diseases and Tropical Medicine Unit, Federal Teaching Hospital, Ido-Ekiti, Ekiti State Nigeria.
  • Ezediuno LO; Department of Medical Microbiology and Parasitology, University of Ilorin, Ilorin, Kwara State Nigeria.
  • Adebayo OI; Genomics Unit, Helix Biogen Consult, Ogbomoso, Oyo State Nigeria.
  • Adebayo ET; Department of Microbiology and Parasitology, University of Ilorin, Ilorin, Kwara State Nigeria.
  • Odeyemi AN; Genomics Unit, Helix Biogen Consult, Ogbomoso, Oyo State Nigeria.
  • Oyeleke MO; Reproduction and Bioinformatics Unit, Department of Medical Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State Nigeria.
  • Oyewole MP; Genomics Unit, Helix Biogen Consult, Ogbomoso, Oyo State Nigeria.
  • Oguntomi AS; Reproduction and Bioinformatics Unit, Department of Medical Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State Nigeria.
  • Akindiya OE; Genomics Unit, Helix Biogen Consult, Ogbomoso, Oyo State Nigeria.
  • Aremu VO; Reproduction and Bioinformatics Unit, Department of Medical Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State Nigeria.
  • Aboderin DO; Genomics Unit, Helix Biogen Consult, Ogbomoso, Oyo State Nigeria.
  • Oloke JK; Reproduction and Bioinformatics Unit, Department of Medical Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State Nigeria.
In Silico Pharmacol ; 9(1): 8, 2021.
Article in English | MEDLINE | ID: covidwho-1009227
ABSTRACT
The widespread of coronavirus (COVID-19) is a new global health crisis that poses a threat to the world. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) originated in bats and was discovered first in Wuhan, Hubei province, China in December 2019. Immunoinformatics and bioinformatics tools were employed for the construction of a multi-epitope subunit vaccine to prevent the diseases. The antigenicity, toxicity and allergenicity of all epitopes used in the construction of the vaccine were predicted and then conjugated with adjuvants and linkers. Vaccine Toll-Like Receptors (2, 3, 4, 8 and 9) complex was also evaluated. The vaccine construct was antigenic, non-toxic and non-allergic, which indicates the vaccines ability to induce antibodies in the host, making it an effective vaccine candidate. SUPPLEMENTARY INFORMATION The online version contains supplementary material available at 10.1007/s40203-020-00062-x.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study Topics: Vaccines Language: English Journal: In Silico Pharmacol Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study Topics: Vaccines Language: English Journal: In Silico Pharmacol Year: 2021 Document Type: Article