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Cerium oxide nanoparticle delivery of microRNA-146a for local treatment of acute lung injury.
Niemiec, Stephen M; Hilton, Sarah A; Wallbank, Alison; Azeltine, Mark; Louiselle, Amanda E; Elajaili, Hanan; Allawzi, Ayed; Xu, Junwang; Mattson, Courtney; Dewberry, Lindel C; Hu, Junyi; Singh, Sushant; Sakthivel, Tamil S; Sea, Sudipta; Nozik-Grayck, Eva; Smith, Bradford; Zgheib, Carlos; Liechty, Kenneth W.
  • Niemiec SM; Laboratory for Fetal and Regenerative Biology, Department of Surgery, University of Colorado Denver School of Medicine and Children's Hospital Colorado, Aurora, CO, USA.
  • Hilton SA; Laboratory for Fetal and Regenerative Biology, Department of Surgery, University of Colorado Denver School of Medicine and Children's Hospital Colorado, Aurora, CO, USA.
  • Wallbank A; Department of Bioengineering, University of Colorado, Aurora, CO, USA.
  • Azeltine M; Laboratory for Fetal and Regenerative Biology, Department of Surgery, University of Colorado Denver School of Medicine and Children's Hospital Colorado, Aurora, CO, USA.
  • Louiselle AE; Laboratory for Fetal and Regenerative Biology, Department of Surgery, University of Colorado Denver School of Medicine and Children's Hospital Colorado, Aurora, CO, USA.
  • Elajaili H; Cardiovascular Pulmonary Research Laboratories and Pediatric Critical Care Medicine, Department of Pediatrics, University of Colorado, Aurora, CO, USA.
  • Allawzi A; Cardiovascular Pulmonary Research Laboratories and Pediatric Critical Care Medicine, Department of Pediatrics, University of Colorado, Aurora, CO, USA.
  • Xu J; Laboratory for Fetal and Regenerative Biology, Department of Surgery, University of Colorado Denver School of Medicine and Children's Hospital Colorado, Aurora, CO, USA.
  • Mattson C; Department of Bioengineering, University of Colorado, Aurora, CO, USA.
  • Dewberry LC; Laboratory for Fetal and Regenerative Biology, Department of Surgery, University of Colorado Denver School of Medicine and Children's Hospital Colorado, Aurora, CO, USA.
  • Hu J; Laboratory for Fetal and Regenerative Biology, Department of Surgery, University of Colorado Denver School of Medicine and Children's Hospital Colorado, Aurora, CO, USA.
  • Singh S; Department of Material Science and Engineering, Advanced Materials Processing and Analysis Center, Nanoscience Technology Center, University of Central Florida, Orlando, FL, USA.
  • Sakthivel TS; Department of Material Science and Engineering, Advanced Materials Processing and Analysis Center, Nanoscience Technology Center, University of Central Florida, Orlando, FL, USA.
  • Sea S; Department of Material Science and Engineering, Advanced Materials Processing and Analysis Center, Nanoscience Technology Center, University of Central Florida, Orlando, FL, USA; College of Medicine, UCF Prosthetics Cluster, University of Central Florida, Orlando, FL, USA.
  • Nozik-Grayck E; Cardiovascular Pulmonary Research Laboratories and Pediatric Critical Care Medicine, Department of Pediatrics, University of Colorado, Aurora, CO, USA.
  • Smith B; Department of Bioengineering, University of Colorado, Aurora, CO, USA.
  • Zgheib C; Laboratory for Fetal and Regenerative Biology, Department of Surgery, University of Colorado Denver School of Medicine and Children's Hospital Colorado, Aurora, CO, USA.
  • Liechty KW; Laboratory for Fetal and Regenerative Biology, Department of Surgery, University of Colorado Denver School of Medicine and Children's Hospital Colorado, Aurora, CO, USA. Electronic address: ken.liechty@cuanschutz.edu.
Nanomedicine ; 34: 102388, 2021 06.
Article in English | MEDLINE | ID: covidwho-1142161
ABSTRACT
Acute respiratory distress syndrome (ARDS) is a devastating pulmonary disease with significant in-hospital mortality and is the leading cause of death in COVID-19 patients. Excessive leukocyte recruitment, unregulated inflammation, and resultant fibrosis contribute to poor ARDS outcomes. Nanoparticle technology with cerium oxide nanoparticles (CNP) offers a mechanism by which unstable therapeutics such as the anti-inflammatory microRNA-146a can be locally delivered to the injured lung without systemic uptake. In this study, we evaluated the potential of the radical scavenging CNP conjugated to microRNA-146a (termed CNP-miR146a) in preventing acute lung injury (ALI) following exposure to bleomycin. We have found that intratracheal delivery of CNP-miR146a increases pulmonary levels of miR146a without systemic increases, and prevents ALI by altering leukocyte recruitment, reducing inflammation and oxidative stress, and decreasing collagen deposition, ultimately improving pulmonary biomechanics.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Distress Syndrome / Bleomycin / Cerium / Drug Delivery Systems / MicroRNAs Type of study: Experimental Studies Limits: Animals Language: English Journal: Nanomedicine Journal subject: Biotechnology Year: 2021 Document Type: Article Affiliation country: J.nano.2021.102388

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Distress Syndrome / Bleomycin / Cerium / Drug Delivery Systems / MicroRNAs Type of study: Experimental Studies Limits: Animals Language: English Journal: Nanomedicine Journal subject: Biotechnology Year: 2021 Document Type: Article Affiliation country: J.nano.2021.102388