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Humanized Mice for Infectious and Neurodegenerative disorders.
Dash, Prasanta K; Gorantla, Santhi; Poluektova, Larisa; Hasan, Mahmudul; Waight, Emiko; Zhang, Chen; Markovic, Milica; Edagwa, Benson; Machhi, Jatin; Olson, Katherine E; Wang, Xinglong; Mosley, R Lee; Kevadiya, Bhavesh; Gendelman, Howard E.
  • Dash PK; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
  • Gorantla S; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
  • Poluektova L; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
  • Hasan M; Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
  • Waight E; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
  • Zhang C; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
  • Markovic M; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
  • Edagwa B; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
  • Machhi J; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
  • Olson KE; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
  • Wang X; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
  • Mosley RL; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
  • Kevadiya B; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
  • Gendelman HE; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA. hegendel@unmc.edu.
Retrovirology ; 18(1): 13, 2021 06 05.
Article in English | MEDLINE | ID: covidwho-1257950
ABSTRACT
Humanized mice model human disease and as such are used commonly for research studies of infectious, degenerative and cancer disorders. Recent models also reflect hematopoiesis, natural immunity, neurobiology, and molecular pathways that influence disease pathobiology. A spectrum of immunodeficient mouse strains permit long-lived human progenitor cell engraftments. The presence of both innate and adaptive immunity enables high levels of human hematolymphoid reconstitution with cell susceptibility to a broad range of microbial infections. These mice also facilitate investigations of human pathobiology, natural disease processes and therapeutic efficacy in a broad spectrum of human disorders. However, a bridge between humans and mice requires a complete understanding of pathogen dose, co-morbidities, disease progression, environment, and genetics which can be mirrored in these mice. These must be considered for understanding of microbial susceptibility, prevention, and disease progression. With known common limitations for access to human tissues, evaluation of metabolic and physiological changes and limitations in large animal numbers, studies in mice prove important in planning human clinical trials. To these ends, this review serves to outline how humanized mice can be used in viral and pharmacologic research emphasizing both current and future studies of viral and neurodegenerative diseases. In all, humanized mouse provides cost-effective, high throughput studies of infection or degeneration in natural pathogen host cells, and the ability to test transmission and eradication of disease.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Mice, SCID / Neurodegenerative Diseases / Disease Models, Animal / Immunity, Innate Type of study: Experimental Studies / Prognostic study Limits: Animals Language: English Journal: Retrovirology Journal subject: Virology Year: 2021 Document Type: Article Affiliation country: S12977-021-00557-1

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Mice, SCID / Neurodegenerative Diseases / Disease Models, Animal / Immunity, Innate Type of study: Experimental Studies / Prognostic study Limits: Animals Language: English Journal: Retrovirology Journal subject: Virology Year: 2021 Document Type: Article Affiliation country: S12977-021-00557-1