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Characteristics and Clinical Course of Adult in Patients with SARS-CoV-2 Pneumonia at High Altitude.
Galindo, Javier Leonardo; Lutz, Juan Ricardo; Izquierdo, María Alejandra; Parra, Katherine; Prieto, Lina María; Carrillo, Jorge Alberto.
  • Galindo JL; Department of Pneumology, Hospital Universitario Mayor Méderi, Bogotá, Colombia.
  • Lutz JR; School of Medicine, Universidad Del Rosario, Bogotá, Colombia.
  • Izquierdo MA; Department of Pneumology, Hospital Universitario Mayor Méderi, Bogotá, Colombia.
  • Parra K; School of Medicine, Universidad Del Rosario, Bogotá, Colombia.
  • Prieto LM; Department of Pneumology, Hospital Universitario Mayor Méderi, Bogotá, Colombia.
  • Carrillo JA; School of Medicine, Universidad Del Rosario, Bogotá, Colombia.
Can Respir J ; 2021: 5590879, 2021.
Article in English | MEDLINE | ID: covidwho-1268149
ABSTRACT

Background:

SARS-CoV-2 has spread worldwide with different dynamics in each region. We aimed to describe the clinical characteristics and to explore risk factors of death, critical care admission, and use of invasive mechanical ventilation in hospitalized patients with SARS-CoV-2 pneumonia in a high-altitude population living in Bogotá, Colombia.

Methods:

We conducted a concurrent cohort study of adult patients with laboratory-confirmed SARS-CoV-2 pneumonia. Demographic, clinical, and treatment data were extracted from electronic records. Univariate and multivariable methods were performed to investigate the relationship between each variable and outcomes at 28 days of follow-up.

Results:

377 adults (56.8% male) were included in the study, of whom 85 (22.6%) died. Nonsurvivors were older on average than survivors (mean age, 56.7 years [SD 15.8] vs. 70.1 years [SD 13.9]; p ≤ 0.001) and more likely male (28 [32.9%] vs. 57 [67.1%]; p=0.029). Most patients had at least one underlying disease (333 [88.3%]), including arterial hypertension (149 [39.5%]), overweight (145 [38.5%]), obesity (114 [30.2%]), and diabetes mellitus (82 [21.8%]). Frequency of critical care admission (158 [41.9%]) and invasive mechanical ventilation (123 [32.6%]) was high. Age over 65 years (OR 9.26, 95% CI 3.29-26.01; p ≤ 0.001), ICU admission (OR 12.37, 95% CI 6.08-25.18; p ≤ 0.001), and arterial pH higher than 7.47 (OR 0.25, 95% CI 0.08-0.74; p=0.01) were independently associated with in-hospital mortality.

Conclusions:

In this study of in-hospital patients with SARS-CoV-2 pneumonia living at high altitude, frequency of death was similar to what has been reported. ICU admission and use of invasive mechanical ventilation were high. Risk factors as older age, ICU admission, and arterial pH were associated with mortality.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Altitude / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: South America / Colombia Language: English Journal: Can Respir J Year: 2021 Document Type: Article Affiliation country: 2021

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Altitude / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: South America / Colombia Language: English Journal: Can Respir J Year: 2021 Document Type: Article Affiliation country: 2021