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Potential Implications of Black Seed and its Principal Constituent Thymoquinone in the Treatment of COVID-19 Patients.
Khan, Masood Alam; Younus, Hina.
  • Khan MA; Department of Basic Health Sciences, College of Applied Medical Sciences, Qassim University, Buraydah, 51452, Saudi Arabia.
  • Younus H; Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, UP, 202002, India.
Curr Pharm Biotechnol ; 22(10): 1315-1324, 2021.
Article in English | MEDLINE | ID: covidwho-1290817
ABSTRACT

BACKGROUND:

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the causative agent of the current pandemic of Coronavirus Disease-2019 (COVID-19). The progression of COVID-19 is related to an excessive host inflammatory immune response to SARS-CoV-2 infection, which is considered a major cause of disease severity and death. Dysregulated immune response produces huge amounts of pro-inflammatory cytokines and chemokines called "cytokine storm". Moreover, the activation of microthrombi formation plays an important role in multiple organ failure.

METHODS:

Keeping into consideration the potent anti-inflammatory activity of black seed and its major constituent Thymoquinone (TQ), we hypothesize their potential implication in the treatment of COVID-19 patients. A literature search was performed in PubMed, ScienceDirect, Google Scholar and Scopus electronic databases using the terms, including black seed, N. sativa, thymoquinone, SARSCoV- 2, COVID-19 and inflammatory immune response.

RESULTS:

Various studies confirmed that Black seed and TQ reduced the thrombus formation, the expression of tissue factor and the immune activation. Furthermore, TQ demonstrated the broad-spectrum antimicrobial activity that may be effective in controlling the secondary infections in COVID-19 patients.

CONCLUSION:

Keeping into consideration the multi-targeting nature of the black seed and TQ, they may be used as a potential therapeutic formulation or as an adjunct therapy in the treatment of COVID-19 patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Prognostic study / Reviews Limits: Humans Language: English Journal: Curr Pharm Biotechnol Journal subject: Biotechnology / Pharmacology Year: 2021 Document Type: Article Affiliation country: 1389201021999201110205048

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Prognostic study / Reviews Limits: Humans Language: English Journal: Curr Pharm Biotechnol Journal subject: Biotechnology / Pharmacology Year: 2021 Document Type: Article Affiliation country: 1389201021999201110205048