The lethal internal face of the coronaviruses: Kidney tropism of the SARS, MERS, and COVID19 viruses.
IUBMB Life
; 73(8): 1005-1015, 2021 08.
Article
in English
| MEDLINE | ID: covidwho-1291220
ABSTRACT
The kidney is one of the main targets attacked by viruses in patients with a coronavirus infection. Until now, SARS-CoV-2 has been identified as the seventh member of the coronavirus family capable of infecting humans. In the past two decades, humankind has experienced outbreaks triggered by two other extremely infective members of the coronavirus family; the MERS-CoV and the SARS-CoV. According to several investigations, SARS-CoV causes proteinuria and renal impairment or failure. The SARS-CoV was identified in the distal convoluted tubules of the kidney of infected patients. Also, renal dysfunction was observed in numerous cases of MERS-CoV infection. And recently, during the 2019-nCoV pandemic, it was found that the novel coronavirus not only induces acute respiratory distress syndrome (ARDS) but also can induce damages in various organs including the liver, heart, and kidney. The kidney tissue and its cells are targeted massively by the coronaviruses due to the abundant presence of ACE2 and Dpp4 receptors on kidney cells. These receptors are characterized as the main route of coronavirus entry to the victim cells. Renal failure due to massive viral invasion can lead to undesirable complications and enhanced mortality rate, thus more attention should be paid to the pathology of coronaviruses in the kidney. Here, we have provided the most recent knowledge on the coronaviruses (SARS, MERS, and COVID19) pathology and the mechanisms of their impact on the kidney tissue and functions.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Coronavirus Infections
/
Severe Acute Respiratory Syndrome
/
Severe acute respiratory syndrome-related coronavirus
/
Viral Tropism
/
Middle East Respiratory Syndrome Coronavirus
/
SARS-CoV-2
/
COVID-19
Type of study:
Prognostic study
Language:
English
Journal:
IUBMB Life
Journal subject:
Molecular Biology
/
Biochemistry
Year:
2021
Document Type:
Article
Affiliation country:
Iub.2516
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