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Viral Interactions with Adaptor-Protein Complexes: A Ubiquitous Trait among Viral Species.
Strazic Geljic, Ivana; Kucan Brlic, Paola; Musak, Lucija; Karner, Dubravka; Ambriovic-Ristov, Andreja; Jonjic, Stipan; Schu, Peter; Rovis, Tihana Lenac.
  • Strazic Geljic I; Center for Proteomics, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia.
  • Kucan Brlic P; Fidelta Ltd., Prilaz baruna Filipovica 29, 10000 Zagreb, Croatia.
  • Musak L; Center for Proteomics, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia.
  • Karner D; Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia.
  • Ambriovic-Ristov A; Fidelta Ltd., Prilaz baruna Filipovica 29, 10000 Zagreb, Croatia.
  • Jonjic S; Center for Proteomics, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia.
  • Schu P; Laboratory for Cell Biology and Signalling, Division of Molecular Biology, Ruder Boskovic Institute, Bijenicka 54, 10000 Zagreb, Croatia.
  • Rovis TL; Center for Proteomics, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia.
Int J Mol Sci ; 22(10)2021 May 17.
Article in English | MEDLINE | ID: covidwho-1383880
ABSTRACT
Numerous viruses hijack cellular protein trafficking pathways to mediate cell entry or to rearrange membrane structures thereby promoting viral replication and antagonizing the immune response. Adaptor protein complexes (AP), which mediate protein sorting in endocytic and secretory transport pathways, are one of the conserved viral targets with many viruses possessing AP-interacting motifs. We present here different mechanisms of viral interference with AP complexes and the functional consequences that allow for efficient viral propagation and evasion of host immune defense. The ubiquity of this phenomenon is evidenced by the fact that there are representatives for AP interference in all major viral families, covered in this review. The best described examples are interactions of human immunodeficiency virus and human herpesviruses with AP complexes. Several other viruses, like Ebola, Nipah, and SARS-CoV-2, are pointed out as high priority disease-causative agents supporting the need for deeper understanding of virus-AP interplay which can be exploited in the design of novel antiviral therapies.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: HIV-1 / Adaptor Proteins, Vesicular Transport / SARS-CoV-2 / Herpesviridae Limits: Humans Language: English Year: 2021 Document Type: Article Affiliation country: IJMS22105274

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Full text: Available Collection: International databases Database: MEDLINE Main subject: HIV-1 / Adaptor Proteins, Vesicular Transport / SARS-CoV-2 / Herpesviridae Limits: Humans Language: English Year: 2021 Document Type: Article Affiliation country: IJMS22105274