The COVIRL-001 Trial: A multicentre, prospective, randomised trial comparing standard of care (SOC) alone, SOC plus hydroxychloroquine monotherapy or SOC plus a combination of hydroxychloroquine and azithromycin in the treatment of non- critical, SARS-CoV-2 PCR-positive population not requiring immediate resuscitation or ventilation but who have evidence of clinical decline: A structured summary of a study protocol for a randomised controlled trial.

Feeney, Eoin; Wallace, Deborah; Cotter, Aoife; Tinago, Willard; McCarthy, Cormac; Keane, David; Hussain, Rabia; Alvarez Barco, Elena; Doran, Peter; Mallon, Patrick

Feeney, Eoin; Wallace, Deborah; Cotter, Aoife; Tinago, Willard; McCarthy, Cormac; Keane, David; Hussain, Rabia; Alvarez Barco, Elena; Doran, Peter; Mallon, Patrick.

Feeney E; St Vincent's University Hospital, Dublin, Ireland.
Wallace D; School of Medicine, University College Dublin, Dublin, Ireland.
Cotter A; School of Medicine, University College Dublin, Dublin, Ireland. deborah.wallace@ucd.ie.
Tinago W; School of Medicine, University College Dublin, Dublin, Ireland.
McCarthy C; Mater Misericordiae University Hospital, Dublin, Ireland.
Keane D; School of Medicine, University College Dublin, Dublin, Ireland.
Hussain R; St Vincent's University Hospital, Dublin, Ireland.
Alvarez Barco E; School of Medicine, University College Dublin, Dublin, Ireland.
Doran P; St Vincent's University Hospital, Dublin, Ireland.
Mallon P; School of Medicine, University College Dublin, Dublin, Ireland.

Trials ; 21(1): 430, 2020 05 25.

Article in English | MEDLINE | ID: covidwho-1388812

Subject(s)

Antiviral Agents/administration & dosage; Azithromycin/administration & dosage; Betacoronavirus/drug effects; Coronavirus Infections/drug therapy; Hydroxychloroquine/administration & dosage; Pneumonia, Viral/drug therapy; Antiviral Agents/adverse effects; Azithromycin/adverse effects; Betacoronavirus/pathogenicity; COVID-19; Coronavirus Infections/diagnosis; Coronavirus Infections/virology; Disease Progression; Drug Administration Schedule; Health Status; Humans; Hydroxychloroquine/adverse effects; Ireland; Multicenter Studies as Topic; Pandemics; Pneumonia, Viral/diagnosis; Pneumonia, Viral/virology; Prospective Studies; Randomized Controlled Trials as Topic; SARS-CoV-2; Time Factors; Treatment Outcome

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Pneumonia, Viral / Coronavirus Infections / Azithromycin / Betacoronavirus / Hydroxychloroquine Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Humans Country/Region as subject: Europa Language: English Journal: Trials Journal subject: Medicine / Therapeutics Year: 2020 Document Type: Article Affiliation country: S13063-020-04407-X

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