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Fucoidan and Lung Function: Value in Viral Infection.
Fitton, J Helen; Park, Ah Young; Karpiniec, Samuel S; Stringer, Damien N.
  • Fitton JH; Marinova Pty Ltd., 249 Kennedy Drive, Cambridge, TAS 7170, Australia.
  • Park AY; Marinova Pty Ltd., 249 Kennedy Drive, Cambridge, TAS 7170, Australia.
  • Karpiniec SS; Marinova Pty Ltd., 249 Kennedy Drive, Cambridge, TAS 7170, Australia.
  • Stringer DN; Marinova Pty Ltd., 249 Kennedy Drive, Cambridge, TAS 7170, Australia.
Mar Drugs ; 19(1)2020 Dec 24.
Article in English | MEDLINE | ID: covidwho-1389434
ABSTRACT
Compromised lung function is a feature of both infection driven and non-infective pathologies. Viral infections-including the current pandemic strain SARS-CoV-2-that affect lung function can cause both acute and long-term chronic damage. SARS-CoV-2 infection suppresses innate immunity and promotes an inflammatory response. Targeting these aspects of SARS-CoV-2 is important as the pandemic affects greater proportions of the population. In clinical and animal studies, fucoidans have been shown to increase innate immunity and decrease inflammation. In addition, dietary fucoidan has been shown to attenuate pulmonary damage in a model of acute viral infection. Direct inhibition of SARS-CoV-2 in vitro has been described, but is not universal. This short review summarizes the current research on fucoidan with regard to viral lung infections and lung damage.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Polysaccharides / SARS-CoV-2 / COVID-19 Drug Treatment / Lung Type of study: Prognostic study Limits: Animals / Humans Language: English Journal subject: Biology / Pharmacology Year: 2020 Document Type: Article Affiliation country: MD19010004

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Polysaccharides / SARS-CoV-2 / COVID-19 Drug Treatment / Lung Type of study: Prognostic study Limits: Animals / Humans Language: English Journal subject: Biology / Pharmacology Year: 2020 Document Type: Article Affiliation country: MD19010004