SARS-CoV-2 transgressing LncRNAs uncovers the known unknowns.
Physiol Genomics
; 53(10): 433-440, 2021 10 01.
Article
in English
| MEDLINE | ID: covidwho-1398739
ABSTRACT
SARS-CoV-2 harbors many known unknown regions in the form of hypothetical open reading frames (ORFs). Although the mechanisms underlying the disease pathogenesis are not clearly understood, molecules such as long noncoding RNAs (lncRNAs) play a key regulatory role in the viral pathogenesis from endocytosis. We asked whether or not the lncRNAs in the host are associated with the viral proteins and argue that lncRNA-mRNAs molecules related to viral infection may regulate SARS-CoV-2 pathogenesis. Toward the end of the perspective, we provide challenges and insights into investigating these transgression pathways.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
RNA, Messenger
/
Host-Pathogen Interactions
/
RNA, Long Noncoding
/
SARS-CoV-2
/
COVID-19
Type of study:
Randomized controlled trials
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Physiol Genomics
Journal subject:
Molecular Biology
Year:
2021
Document Type:
Article
Affiliation country:
Physiolgenomics.00075.2021
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