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Antirheumatic Drug Intake Influence on Occurrence of COVID-19 Infection in Ambulatory Patients with Immune-Mediated Inflammatory Diseases: A Cohort Study.
Guillaume, Debellemanière; Magalie, Bouvet; Sina, Elahi; Imène, Salah-Mabed; Frédéric, Vayr; Mathieu, Dubois; Aurore, Muselier; Yoni, Gozlan; Emma, Elbaz; Charlotte, Badatcheff; Laura, Fabre; Alain, Saad; Steven, Nahaisi; Pierre, Zeboulon; Jean-Luc, Febbraro; Romain, Courtin; Alice, Grise-Dulac; Adrien, Mazharian; Wassim, Ghazal; Pierre-Emmanuel, Remongin; Christophe, Panthier; Catherine, Chirouze; Kevin, Bertrand; Thomas, Sené; Damien, Gatinel.
  • Guillaume D; Adolphe de Rothschild Foundation Hospital, 29 Rue Manin, Paris, France.
  • Magalie B; Adolphe de Rothschild Foundation Hospital, 29 Rue Manin, Paris, France.
  • Sina E; Adolphe de Rothschild Foundation Hospital, 29 Rue Manin, Paris, France.
  • Imène SM; Adolphe de Rothschild Foundation Hospital, 29 Rue Manin, Paris, France.
  • Frédéric V; Adolphe de Rothschild Foundation Hospital, 29 Rue Manin, Paris, France.
  • Mathieu D; Adolphe de Rothschild Foundation Hospital, 29 Rue Manin, Paris, France.
  • Aurore M; Adolphe de Rothschild Foundation Hospital, 29 Rue Manin, Paris, France.
  • Yoni G; Adolphe de Rothschild Foundation Hospital, 29 Rue Manin, Paris, France.
  • Emma E; Adolphe de Rothschild Foundation Hospital, 29 Rue Manin, Paris, France.
  • Charlotte B; Adolphe de Rothschild Foundation Hospital, 29 Rue Manin, Paris, France.
  • Laura F; Adolphe de Rothschild Foundation Hospital, 29 Rue Manin, Paris, France.
  • Alain S; Adolphe de Rothschild Foundation Hospital, 29 Rue Manin, Paris, France.
  • Steven N; Adolphe de Rothschild Foundation Hospital, 29 Rue Manin, Paris, France.
  • Pierre Z; Adolphe de Rothschild Foundation Hospital, 29 Rue Manin, Paris, France.
  • Jean-Luc F; Adolphe de Rothschild Foundation Hospital, 29 Rue Manin, Paris, France.
  • Romain C; Adolphe de Rothschild Foundation Hospital, 29 Rue Manin, Paris, France.
  • Alice GD; Adolphe de Rothschild Foundation Hospital, 29 Rue Manin, Paris, France.
  • Adrien M; Adolphe de Rothschild Foundation Hospital, 29 Rue Manin, Paris, France.
  • Wassim G; Adolphe de Rothschild Foundation Hospital, 29 Rue Manin, Paris, France.
  • Pierre-Emmanuel R; Adolphe de Rothschild Foundation Hospital, 29 Rue Manin, Paris, France.
  • Christophe P; Adolphe de Rothschild Foundation Hospital, 29 Rue Manin, Paris, France.
  • Catherine C; Jean Minjoz University Hospital, Besançon, France.
  • Kevin B; Perpignan Hospital, Perpignan, France.
  • Thomas S; Adolphe de Rothschild Foundation Hospital, 29 Rue Manin, Paris, France.
  • Damien G; Adolphe de Rothschild Foundation Hospital, 29 Rue Manin, Paris, France. gatinel@gmail.com.
Rheumatol Ther ; 8(4): 1887-1895, 2021 Dec.
Article in English | MEDLINE | ID: covidwho-1412508
ABSTRACT

INTRODUCTION:

We aimed to study the prevalence of a history of COVID-19 infection among patients suffering from systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjögren's syndrome (SjS) or psoriatic arthritis (PsA), and the potential influence of long-term hydroxychloroquine (HCQ) intake.

METHODS:

We performed an observational monocentric cohort study at the Adolphe de Rothschild Foundation Hospital ophthalmology division (Paris, France). Electronic medical records (EMR) data were searched for keywords associated with SLE, RA, SjS, or PsA. Patients were contacted by phone and were interviewed using a standardized questionnaire. The primary outcome was the occurrence of a positive COVID-19 test result during the study period. We determined the adjusted association between various antirheumatic drugs intake, COVID-19 risk factors, and occurrence of COVID-19 using a logistic regression model. This study is registered on ClinicalTrials.gov (Identifier NCT04345159).

RESULTS:

Patients were recruited between Apr 17, 2020, and Apr 30, 2020 and were recontacted between Oct 6, 2020, and Nov 2, 2020. A total of 569 patients were included, of whom 459 patients were eligible for data analysis. One hundred and eighty-one patients were treated with long-term HCQ and 18 patients had tested positive for COVID-19. No antirheumatic drug intake, including HCQ intake, was significantly associated with an increased or decreased risk of developing COVID-19 infection.

CONCLUSIONS:

No antirheumatic drug intake was associated with an increased or decreased risk of developing COVID-19 infection in our cohort of patients suffering from immune-mediated inflammatory diseases.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Language: English Journal: Rheumatol Ther Year: 2021 Document Type: Article Affiliation country: S40744-021-00373-1

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Language: English Journal: Rheumatol Ther Year: 2021 Document Type: Article Affiliation country: S40744-021-00373-1