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Electroceutical fabric lowers zeta potential and eradicates coronavirus infectivity upon contact.
Ghatak, Subhadip; Khona, Dolly K; Sen, Abhishek; Huang, Kaixiang; Jagdale, Gargi; Singh, Kanhaiya; Gopalakrishnan, Vinoj; Cornetta, Kenneth G; Roy, Sashwati; Khanna, Savita; Baker, Lane A; Sen, Chandan K.
  • Ghatak S; Indiana Center for Regenerative Medicine and Engineering at Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
  • Khona DK; Indiana Center for Regenerative Medicine and Engineering at Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
  • Sen A; Indiana Center for Regenerative Medicine and Engineering at Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
  • Huang K; Department of Chemistry, Indiana University, Bloomington, IN, 47405, USA.
  • Jagdale G; Department of Chemistry, Indiana University, Bloomington, IN, 47405, USA.
  • Singh K; Indiana Center for Regenerative Medicine and Engineering at Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
  • Gopalakrishnan V; Indiana Center for Regenerative Medicine and Engineering at Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
  • Cornetta KG; Department of Medical and Molecular Genetics at Indiana University School of Medicine, Indianapolis, IN, USA.
  • Roy S; Indiana Center for Regenerative Medicine and Engineering at Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
  • Khanna S; Indiana Center for Regenerative Medicine and Engineering at Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
  • Baker LA; Department of Chemistry, Indiana University, Bloomington, IN, 47405, USA.
  • Sen CK; Indiana Center for Regenerative Medicine and Engineering at Indiana University School of Medicine, Indianapolis, IN, 46202, USA. cksen@iu.edu.
Sci Rep ; 11(1): 21723, 2021 11 05.
Article in English | MEDLINE | ID: covidwho-1503978
Preprint
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ABSTRACT
Coronavirus with intact infectivity attached to PPE surfaces pose significant threat to the spread of COVID-19. We tested the hypothesis that an electroceutical fabric, generating weak potential difference of 0.5 V, disrupts the infectivity of coronavirus upon contact by destabilizing the electrokinetic properties of the virion. Porcine respiratory coronavirus AR310 particles (105) were placed in direct contact with the fabric for 1 or 5 min. Following one minute of contact, zeta potential of the porcine coronavirus was significantly lowered indicating destabilization of its electrokinetic properties. Size-distribution plot showed appearance of aggregation of the virus. Testing of the cytopathic effects of the virus showed eradication of infectivity as quantitatively assessed by PI-calcein and MTT cell viability tests. This work provides the rationale to consider the studied electroceutical fabric, or other materials with comparable property, as material of choice for the development of PPE in the fight against COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Textiles / Electrochemistry / COVID-19 Type of study: Prognostic study Limits: Animals / Humans Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-00910-6

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Textiles / Electrochemistry / COVID-19 Type of study: Prognostic study Limits: Animals / Humans Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-00910-6