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COVID-19 Patient Management in Outpatient Setting: A Population-Based Study from Southern Italy.
Crisafulli, Salvatore; Ientile, Valentina; L'Abbate, Luca; Fontana, Andrea; Linguiti, Claudio; Manna, Sonia; Mercaldo, Mariangela; Pagliaro, Claudia; Vezzaro, Michele; Santacà, Katia; Lora, Riccardo; Moretti, Ugo; Reno, Chiara; Fantini, Maria Pia; Corrao, Salvatore; Barbato, Donato; Tari, Michele; Trifirò, Gianluca.
  • Crisafulli S; Department of Medicine, University of Verona, 37134 Verona, Italy.
  • Ientile V; Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98125 Messina, Italy.
  • L'Abbate L; Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy.
  • Fontana A; Unit of Biostatistics, Fondazione IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Italy.
  • Linguiti C; Caserta Local Health Unit, 81100 Caserta, Italy.
  • Manna S; Caserta Local Health Unit, 81100 Caserta, Italy.
  • Mercaldo M; Caserta Local Health Unit, 81100 Caserta, Italy.
  • Pagliaro C; Caserta Local Health Unit, 81100 Caserta, Italy.
  • Vezzaro M; Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy.
  • Santacà K; Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy.
  • Lora R; Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy.
  • Moretti U; Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy.
  • Reno C; Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy.
  • Fantini MP; Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy.
  • Corrao S; Department of Health Promotion Sciences, Maternal and Infant Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, 90127 Palermo, Italy.
  • Barbato D; Department of Internal Medicine, National Relevance and High Specialization Hospital Trust ARNAS Civico, Di Cristina, Benfratelli, 90127 Palermo, Italy.
  • Tari M; IQVIA, 20124 Milan, Italy.
  • Trifirò G; Caserta Local Health Unit, 81100 Caserta, Italy.
  • The Ita-Covid Cov-Out Group; Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy.
J Clin Med ; 11(1)2021 Dec 23.
Article in English | MEDLINE | ID: covidwho-1580655
ABSTRACT
Evidence on treatments for early-stage COVID-19 in outpatient setting is sparse. We explored the pattern of use of drugs prescribed for COVID-19 outpatients' management in Southern Italy in the period February 2020-January 2021. This population-based cohort study was conducted using COVID-19 surveillance registry from Caserta Local Health Unit, which was linked to claims databases from the same catchment area. The date of SARS-CoV-2 infection diagnosis was the index date (ID). We evaluated demographic and clinical characteristics of the study drug users and the pattern of use of drugs prescribed for outpatient COVID-19 management. Overall, 40,030 patients were included in the analyses, with a median (IQR) age of 44 (27-58) years. More than half of the included patients were asymptomatic at the ID. Overall, during the study period, 720 (1.8%) patients died due to COVID-19. Azithromycin and glucocorticoids were the most frequently prescribed drugs, while oxygen was the less frequently prescribed therapy. The cumulative rate of recovery from COVID-19 was 84.2% at 30 days from ID and it was lower among older patients. In this study we documented that the drug prescribing patterns for COVID-19 treatment in an outpatient setting from Southern Italy was not supported from current evidence on beneficial therapies for early treatment of COVID-19, thus highlighting the need to implement strategies for improving appropriate drug prescribing in general practice.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Language: English Year: 2021 Document Type: Article Affiliation country: Jcm11010051

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Language: English Year: 2021 Document Type: Article Affiliation country: Jcm11010051