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Natural rodent model of viral transmission reveals biological features of virus population dynamics.
Fay, Elizabeth J; Balla, Keir M; Roach, Shanley N; Shepherd, Frances K; Putri, Dira S; Wiggen, Talia D; Goldstein, Stephen A; Pierson, Mark J; Ferris, Martin T; Thefaine, Claire E; Tucker, Andrew; Salnikov, Mark; Cortez, Valerie; Compton, Susan R; Kotenko, Sergei V; Hunter, Ryan C; Masopust, David; Elde, Nels C; Langlois, Ryan A.
  • Fay EJ; Biochemistry, Molecular Biology and Biophysics Graduate Program, University of Minnesota, Minneapolis, MN.
  • Balla KM; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN.
  • Roach SN; Center for Immunology, University of Minnesota, Minneapolis, MN.
  • Shepherd FK; Department of Human Genetics, University of Utah, Salt Lake City, UT.
  • Putri DS; Biochemistry, Molecular Biology and Biophysics Graduate Program, University of Minnesota, Minneapolis, MN.
  • Wiggen TD; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN.
  • Goldstein SA; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN.
  • Pierson MJ; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN.
  • Ferris MT; Microbiology, Immunology and Cancer Biology Graduate Program, University of Minnesota, Minneapolis, MN.
  • Thefaine CE; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN.
  • Tucker A; Department of Human Genetics, University of Utah, Salt Lake City, UT.
  • Salnikov M; Center for Immunology, University of Minnesota, Minneapolis, MN.
  • Cortez V; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC.
  • Compton SR; Microbiology, Immunology and Cancer Biology Graduate Program, University of Minnesota, Minneapolis, MN.
  • Kotenko SV; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN.
  • Hunter RC; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN.
  • Masopust D; Department of Molecular, Cellular and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA.
  • Elde NC; Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT.
  • Langlois RA; Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, NJ.
J Exp Med ; 219(2)2022 02 07.
Article in English | MEDLINE | ID: covidwho-1593236
ABSTRACT
Emerging viruses threaten global health, but few experimental models can characterize the virus and host factors necessary for within- and cross-species transmission. Here, we leverage a model whereby pet store mice or rats-which harbor natural rodent pathogens-are cohoused with laboratory mice. This "dirty" mouse model offers a platform for studying acute transmission of viruses between and within hosts via natural mechanisms. We identified numerous viruses and other microbial species that transmit to cohoused mice, including prospective new members of the Coronaviridae, Astroviridae, Picornaviridae, and Narnaviridae families, and uncovered pathogen interactions that promote or prevent virus transmission. We also evaluated transmission dynamics of murine astroviruses during transmission and spread within a new host. Finally, by cohousing our laboratory mice with the bedding of pet store rats, we identified cross-species transmission of a rat astrovirus. Overall, this model system allows for the analysis of transmission of natural rodent viruses and is a platform to further characterize barriers to zoonosis.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Virus Diseases / Disease Models, Animal / Disease Susceptibility Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Animals / Humans Language: English Year: 2022 Document Type: Article Affiliation country: Jem.20211220

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Virus Diseases / Disease Models, Animal / Disease Susceptibility Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Animals / Humans Language: English Year: 2022 Document Type: Article Affiliation country: Jem.20211220