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Monogenic autoimmunity and infectious diseases: the double-edged sword of immune dysregulation.
Bigley, Tarin M; Cooper, Megan A.
  • Bigley TM; Department of Pediatrics, Division of Rheumatology/Immunology, Washington University in St. Louis, St. Louis, MO, 63110, United States.
  • Cooper MA; Department of Pediatrics, Division of Rheumatology/Immunology, Washington University in St. Louis, St. Louis, MO, 63110, United States. Electronic address: Cooper_m@wustl.edu.
Curr Opin Immunol ; 72: 230-238, 2021 10.
Article in English | MEDLINE | ID: covidwho-1603901
ABSTRACT
The study of monogenic autoimmune diseases has provided key insights into molecular mechanisms involved in development of autoimmunity and immune tolerance. It has also become clear that such inborn errors of immunity (IEIs) frequently present clinically not only with autoimmune diseases, but also frequently have increased susceptibility to infection. The genes associated with monogenic autoimmunity influence diverse functional pathways, and the resulting immune dysregulation also impacts the complex and coordinated immune response to pathogens, for example type I interferon and cytokine signaling, the complement pathway and proper differentiation of the immune response. The SARS-CoV-2 pandemic has highlighted how monogenic autoimmunity can increase risk for serious infection with the discovery of severe disease in patients with pre-existing antibodies to Type I IFNs. This review discusses recent insight into the relationship between monogenic autoimmunity and infectious diseases.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Autoimmune Diseases / Communicable Diseases / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Limits: Animals / Humans Language: English Journal: Curr Opin Immunol Journal subject: Allergy and Immunology Year: 2021 Document Type: Article Affiliation country: J.coi.2021.06.013

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Autoimmune Diseases / Communicable Diseases / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Limits: Animals / Humans Language: English Journal: Curr Opin Immunol Journal subject: Allergy and Immunology Year: 2021 Document Type: Article Affiliation country: J.coi.2021.06.013