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Impact of booster vaccination on the control of COVID-19 Delta wave in the context of waning immunity: application to France in the winter 2021/22.
Bosetti, Paolo; Tran Kiem, Cécile; Andronico, Alessio; Paireau, Juliette; Levy-Bruhl, Daniel; Alter, Lise; Fontanet, Arnaud; Cauchemez, Simon.
  • Bosetti P; Mathematical Modelling of Infectious Diseases Unit, Institut Pasteur, Université de Paris, CNRS UMR2000, Paris, France.
  • Tran Kiem C; Mathematical Modelling of Infectious Diseases Unit, Institut Pasteur, Université de Paris, CNRS UMR2000, Paris, France.
  • Andronico A; Collège Doctoral, Sorbonne Université, Paris, France.
  • Paireau J; Mathematical Modelling of Infectious Diseases Unit, Institut Pasteur, Université de Paris, CNRS UMR2000, Paris, France.
  • Levy-Bruhl D; Mathematical Modelling of Infectious Diseases Unit, Institut Pasteur, Université de Paris, CNRS UMR2000, Paris, France.
  • Alter L; Santé publique France, French National Public Health Agency, Saint-Maurice, France.
  • Fontanet A; Santé publique France, French National Public Health Agency, Saint-Maurice, France.
  • Cauchemez S; Haute Autorité de Santé, Saint-Denis la Plaine, France.
Euro Surveill ; 27(1)2022 01.
Article in English | MEDLINE | ID: covidwho-1613513
ABSTRACT
Europe has experienced a large COVID-19 wave caused by the Delta variant in winter 2021/22. Using mathematical models applied to Metropolitan France, we find that boosters administered to ≥ 65, ≥ 50 or ≥ 18 year-olds may reduce the hospitalisation peak by 25%, 36% and 43% respectively, with a delay of 5 months between second and third dose. A 10% reduction in transmission rates might further reduce it by 41%, indicating that even small increases in protective behaviours may be critical to mitigate the wave.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunization, Secondary / COVID-19 Vaccines / COVID-19 Type of study: Experimental Studies / Observational study Topics: Vaccines / Variants Limits: Humans Country/Region as subject: Europa Language: English Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: 1560-7917.Es.2022.27.1.2101125

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunization, Secondary / COVID-19 Vaccines / COVID-19 Type of study: Experimental Studies / Observational study Topics: Vaccines / Variants Limits: Humans Country/Region as subject: Europa Language: English Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: 1560-7917.Es.2022.27.1.2101125