Bhimamycin J, a Rare Benzo[f]isoindole-dione Alkaloid from the Marine-Derived Actinomycete Streptomyces sp. MS180069.
Chem Biodivers
; 18(11): e2100674, 2021 Nov.
Article
in English
| MEDLINE | ID: covidwho-1615945
ABSTRACT
Chemical investigation on a Streptomyces sp. strain MS180069 isolated from a sediment sample collected from the South China Sea, yielded the new benzo[f]isoindole-dione alkaloid, bhimamycin J (1). The structure was determined by extensive spectroscopic analysis, including HRMS, 1D, 2D NMR, and X-ray diffraction techniques. A molecular docking study revealed 1 as a new molecular motif that binds with human angiotensin converting enzyme2 (ACE2), recently described as the cell surface receptor responsible for uptake of 2019-CoV-2. Using enzyme assays we confirm that 1 inhibits human ACE2 79.7 % at 25â
µg/mL.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Streptomyces
/
Geologic Sediments
/
Alkaloids
/
Isoindoles
Limits:
Humans
Language:
English
Journal:
Chem Biodivers
Journal subject:
Biochemistry
/
Chemistry
Year:
2021
Document Type:
Article
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