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Two novel human coronavirus OC43 genotypes circulating in hospitalized children with pneumonia in China.
Zhang, Zhaoyong; Liu, Wenkuan; Zhang, Shengnan; Wei, Peilan; Zhang, Lu; Chen, Dehui; Qiu, Shuyan; Li, Xiaobo; Zhao, Jingxian; Shi, Yongxia; Zhou, Rong; Wang, Yanqun; Zhao, Jincun.
  • Zhang Z; State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, People's Republic of China.
  • Liu W; State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, People's Republic of China.
  • Zhang S; State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, People's Republic of China.
  • Wei P; State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, People's Republic of China.
  • Zhang L; Guangzhou Customs District Technology Centre, Guangzhou, People's Republic of China.
  • Chen D; State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, People's Republic of China.
  • Qiu S; State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, People's Republic of China.
  • Li X; Guangzhou Customs District Technology Centre, Guangzhou, People's Republic of China.
  • Zhao J; State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, People's Republic of China.
  • Shi Y; Guangzhou Customs District Technology Centre, Guangzhou, People's Republic of China.
  • Zhou R; State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, People's Republic of China.
  • Wang Y; State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, People's Republic of China.
  • Zhao J; State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, People's Republic of China.
Emerg Microbes Infect ; 11(1): 168-171, 2022 Dec.
Article in English | MEDLINE | ID: covidwho-1623181
ABSTRACT
HCoV-OC43 is one of the mildly pathogenic coronaviruses with high infection rates in common population. Here, 43 HCoV-OC43 related cases with pneumonia were reported, corresponding genomes of HCoV-OC43 were obtained. Phylogenetic analyses based on complete genome, orf1ab and spike genes revealed that two novel genotypes of HCoV-OC43 have emerged in China. Obvious recombinant events also can be detected in the analysis of the evolutionary dynamics of novel HCoV-OC43 genotypes. Estimated divergence time analysis indicated that the two novel genotypes had apparently independent evolutionary routes. Efforts should be conducted for further investigation of genomic diversity and evolution analysis of mildly pathogenic coronaviruses.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Genome, Viral / Coronavirus Infections / Common Cold / Coronavirus OC43, Human / Genotype Type of study: Observational study / Prognostic study / Randomized controlled trials Limits: Child / Child, preschool / Female / Humans / Infant / Male Country/Region as subject: Asia Language: English Journal: Emerg Microbes Infect Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Genome, Viral / Coronavirus Infections / Common Cold / Coronavirus OC43, Human / Genotype Type of study: Observational study / Prognostic study / Randomized controlled trials Limits: Child / Child, preschool / Female / Humans / Infant / Male Country/Region as subject: Asia Language: English Journal: Emerg Microbes Infect Year: 2022 Document Type: Article