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Metabolic-Associated Fatty Liver Disease Is Highly Prevalent in the Postacute COVID Syndrome.
Milic, Jovana; Barbieri, Sara; Gozzi, Licia; Brigo, Alberto; Beghé, Bianca; Verduri, Alessia; Bacca, Erica; Iadisernia, Vittorio; Cuomo, Gianluca; Dolci, Giovanni; Yaacoub, Dina; Aprile, Emanuele; Belli, Michela; Venuta, Maria; Meschiari, Marianna; Sebastiani, Giada; Clini, Enrico; Mussini, Cristina; Lonardo, Amedeo; Guaraldi, Giovanni; Raggi, Paolo.
  • Milic J; Department of Surgical, Medical, Dental and Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy.
  • Barbieri S; Department of Surgical, Medical, Dental and Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy.
  • Gozzi L; Department of Surgical, Medical, Dental and Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy.
  • Brigo A; University of Modena and Reggio Emilia, Modena, Italy.
  • Beghé B; Respiratory Unit, Azienda Ospedaliero-Universitaria, Policlinico of Modena, Modena, Italy.
  • Verduri A; Respiratory Unit, Azienda Ospedaliero-Universitaria, Policlinico of Modena, Modena, Italy.
  • Bacca E; Department of Infectious Diseases, Azienda Ospedaliero-Universitaria, Policlinico of Modena, Modena, Italy.
  • Iadisernia V; Department of Infectious Diseases, Azienda Ospedaliero-Universitaria, Policlinico of Modena, Modena, Italy.
  • Cuomo G; Department of Infectious Diseases, Azienda Ospedaliero-Universitaria, Policlinico of Modena, Modena, Italy.
  • Dolci G; Department of Infectious Diseases, Azienda Ospedaliero-Universitaria, Policlinico of Modena, Modena, Italy.
  • Yaacoub D; Department of Infectious Diseases, Azienda Ospedaliero-Universitaria, Policlinico of Modena, Modena, Italy.
  • Aprile E; Department of Infectious Diseases, Azienda Ospedaliero-Universitaria, Policlinico of Modena, Modena, Italy.
  • Belli M; Department of Infectious Diseases, Azienda Ospedaliero-Universitaria, Policlinico of Modena, Modena, Italy.
  • Venuta M; Department of Infectious Diseases, Azienda Ospedaliero-Universitaria, Policlinico of Modena, Modena, Italy.
  • Meschiari M; Department of Infectious Diseases, Azienda Ospedaliero-Universitaria, Policlinico of Modena, Modena, Italy.
  • Sebastiani G; Division of Experimental Medicine, McGill University, Montreal, Québec, Canada.
  • Clini E; Division of Gastroenterology and Hepatology, McGill University Health Centre, Montreal, Québec, Canada.
  • Mussini C; Respiratory Unit, Azienda Ospedaliero-Universitaria, Policlinico of Modena, Modena, Italy.
  • Lonardo A; Department of Surgical, Medical, Dental and Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy.
  • Guaraldi G; Respiratory Unit, Azienda Ospedaliero-Universitaria, Policlinico of Modena, Modena, Italy.
  • Raggi P; Department of Internal Medicine, Azienda Ospedaliero-Universitaria, Ospedale Civile di Baggiovara, Modena, Italy.
Open Forum Infect Dis ; 9(3): ofac003, 2022 Mar.
Article in English | MEDLINE | ID: covidwho-1684767
ABSTRACT

BACKGROUND:

A proposal has recently been advanced to change the traditional definition of nonalcoholic fatty liver disease to metabolic-associated fatty liver disease (MAFLD), to reflect the cluster of metabolic abnormalities that may be more closely associated with cardiovascular risk. Long coronavirus disease 2019 (COVID-19) is a smoldering inflammatory condition, characterized by several symptom clusters. This study aims to determine the prevalence of MAFLD in patients with postacute COVID syndrome (PACS) and its association with other PACS-cluster phenotypes.

METHODS:

We included 235 patients observed at a single university outpatient clinic. The diagnosis of PACS was based on ≥1 cluster of symptoms respiratory, neurocognitive, musculoskeletal, psychological, sensory, and dermatological. The outcome was prevalence of MAFLD detected by transient elastography during the first postdischarge follow-up outpatient visit. The prevalence of MAFLD at the time of hospital admission was calculated retrospectively using the hepatic steatosis index.

RESULTS:

Of 235 patients, 162 (69%) were men (median age 61). The prevalence of MAFLD was 55.3% at follow-up and 37.3% on admission (P < .001). Insulin resistance (odds ratio [OR] = 1.5; 95% confidence interval [CI], 1.14-1.96), body mass index (OR = 1.14; 95% CI, 1.04-1.24), and the metabolic syndrome (OR = 2.54; 95% CI, 1.13-5.68) were independent predictors of MAFLD. The number of PACS clusters was inversely associated with MAFLD (OR = 0.86; 95% CI, .76-0.97). Thirty-one patients (13.2%) had MAFLD with no other associated PACS clusters. All correlations between MAFLD and other PACS clusters were weak.

CONCLUSIONS:

Metabolic-associated fatty liver disease was highly prevalent after hospital discharge and may represent a specific PACS-cluster phenotype, with potential long-term metabolic and cardiovascular health implications.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Language: English Journal: Open Forum Infect Dis Year: 2022 Document Type: Article Affiliation country: Ofid

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Language: English Journal: Open Forum Infect Dis Year: 2022 Document Type: Article Affiliation country: Ofid