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A Comprehensive Biological and Synthetic Perspective on 2-Deoxy-d-Glucose (2-DG), A Sweet Molecule with Therapeutic and Diagnostic Potentials.
Wijayasinghe, Yasanandana S; Bhansali, Meenakshi P; Borkar, Maheshkumar R; Chaturbhuj, Ganesh U; Muntean, Brian S; Viola, Ronald E; Bhansali, Pravin R.
  • Wijayasinghe YS; Department of Biochemistry and Clinical Chemistry, Faculty of Medicine, University of Kelaniya, Ragama 11010, Sri Lanka.
  • Bhansali MP; Aspiration Academy, Osmanpura, Aurangabad 431005, Maharashtra, India.
  • Borkar MR; Department of Pharmaceutical Chemistry, SVKM's Dr. Bhanuben Nanavati College of Pharmacy, Vile Parle (W), Mumbai 400056, Maharashtra, India.
  • Chaturbhuj GU; Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga (E), Mumbai 400019, Maharashtra, India.
  • Muntean BS; Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, Georgia 30912, United States.
  • Viola RE; Department of Chemistry and Biochemistry, University of Toledo, Toledo, Ohio 43606, United States.
  • Bhansali PR; Department of Science, Faculty of Science and Technology, Alliance University, Chikkahagade Cross, Chandapura-Anekal Main Road, Anekal, Bengaluru 562106, Karnataka, India.
J Med Chem ; 65(5): 3706-3728, 2022 03 10.
Article in English | MEDLINE | ID: covidwho-1699705
ABSTRACT
Glucose, the primary substrate for ATP synthesis, is catabolized during glycolysis to generate ATP and precursors for the synthesis of other vital biomolecules. Opportunistic viruses and cancer cells often hijack this metabolic machinery to obtain energy and components needed for their replication and proliferation. One way to halt such energy-dependent processes is by interfering with the glycolytic pathway. 2-Deoxy-d-glucose (2-DG) is a synthetic glucose analogue that can inhibit key enzymes in the glycolytic pathway. The efficacy of 2-DG has been reported across an array of diseases and disorders, thereby demonstrating its broad therapeutic potential. Recent approval of 2-DG in India as a therapeutic approach for the management of the COVID-19 pandemic has brought renewed attention to this molecule. The purpose of this perspective is to present updated therapeutic avenues as well as a variety of chemical synthetic strategies for this medically useful sugar derivative, 2-DG.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Deoxyglucose / COVID-19 Drug Treatment Type of study: Diagnostic study Limits: Humans Language: English Journal: J Med Chem Journal subject: Chemistry Year: 2022 Document Type: Article Affiliation country: Acs.jmedchem.1c01737

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Deoxyglucose / COVID-19 Drug Treatment Type of study: Diagnostic study Limits: Humans Language: English Journal: J Med Chem Journal subject: Chemistry Year: 2022 Document Type: Article Affiliation country: Acs.jmedchem.1c01737